Drug designers in anaesthesia.
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Drug Design↗
Biomedical subjects
D V Rutter
Publications and source records attributed to D V Rutter.
Extradural opioids for postoperative analgesia. A double-blind comparison of pethidine, fentanyl and morphine.
Pethidine 50 mg, fentanyl 100 microgram and morphine 2 mg administered to the extradural space, were compared in the treatment of pain following surgery. All three drugs produced a rapid decrease in pain scores as assessed using a visual linear analogue, morphine being the least effective. Fentanyl had a relatively short duration of action (2 h), whereas morphine appeared to be the longest acting. It is suggested that the best relief of pain would be obtained by incremental doses given extradurally. All drugs produced an increase in sedation, but there was no respiratory depression as assessed by PaCO2 measurement.
Adult↗
An indication for hypnosis.
A case of idiopathic pulmonary hypertension in a girl who refused local anaesthesia for dental treatment is described. The dental work was successfully managed utilising hypnosis.
Adult↗
ICI 35868 (Diprivan): a new intravenous induction agent. A comparison with methohexitone.
ICI 35868 (Diprivan) has been used as an induction agent in patients undergoing minor gynaecological surgery and as the sole anaesthetic agent during bronchoscopy, and its effects were compared with those of methohexitone. The new agent proved to be satisfactory, although induction of anaesthesia was significantly longer than following methohexitone. complications were similar with both drugs. ICI 35868 deserves full investigation as an intravenous anaesthetic agent.
Adult↗