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Biomedical subjects

D V Kulaev

Publications and source records attributed to D V Kulaev.

26 records · Page 2Linked to original sources
PubMedDate not supplied

[Lavage of the infected peritoneal cavity using agarose-based immunoaffinity gel sorbents].

In the paper antistaphylococcus and polymixine liquid sorbents are used to lavage infected rat abdominal cavity against gram-positive and gram-negative microfloral toxins. Sorbents have been revealed to remove erythrocyte antigens from the surface, that are affine to immobilized ligands on the matrix. Polymyxine affine sorbent arises quality of the usual lavage of the infected abdomen. 3 hour lavage by fresh portions of the affine sorbent removes fixed toxins from the abdominal surface. Sorbent injection into purulent abdomen for 24 hours provides blood detoxication.

Animals↗
PubMedDate not supplied

[Use of liquid sorbents based on chitosan for treatment of diffuse forms of peritonitis].

Chitosan-based gelatinous affinity sorbent containing 9 mg/ml of polymyxin B was injected into the infected peritoneal cavity for twenty-four hours for detoxification in diffuse peritonitis. The clinical assay of blood plasma (Spectrum Abbot, USA) revealed that the lavage of the infected abdomen by polymyxin B-containing adsorbent resulted in systemic detoxification. The effect was associated with normalization of direct bilirubin, cholesterol, and triglyceride levels, a 4-fold decrease in uric acid levels, and a 34-fold increase in alkaline phosphatase activity, and a greater than 70-fold enhancement of hepatic aspartate aminotransferase activity.

Animals↗
PubMedDate not supplied

[The immunocorrective potentials of an antistaphylococcal immunosorbent in extracting staphylotoxin].

The immunocorrective effect of antistaphylococcal adsorbent prepared on the basis of silochrome, a silica matrix, has been revealed in experiments on peripheral blood lymphocytes obtained from 18 donors. The expression of receptors on human immunoregulating cells has been suppressed by the addition of staphylotoxin at a toxic concentration into the system. The experiments have shown that immunosorption is capable of extracting the toxin from the solution to a considerable degree, thus preventing the suppression of the receptor apparatus of immunoregulating lymphocytes. Staphylotoxin has been found capable of forming complexes with plasma ingredients, which increases the adsorption capacity of the immunosorbent.

Adjuvants, Immunologic↗