Search PubMed⌕ Search

Biomedical subjects

D V Kazakov

Publications and source records attributed to D V Kazakov.

29 records · Page 2Linked to original sources
PubMed2003

Unusual manifestation of specific cutaneous involvement by B-cell chronic lymphocytic leukemia: spontaneous regression with scar formation.

We report a patient with specific cutaneous involvement by B-cell chronic lymphocytic leukemia, who demonstrated unusual clinical features during the course of the disease, namely several spontaneous regressions of skin lesions with the formation of scars. In addition, histologically proven keratoacanthoma was found. During the follow-up period of approximately 1.5 years, the patient experienced several recurrences of skin lesions and their partial spontaneous regression. The scars persisted and remained unchanged. We hypothesize that vascular injury combined with edema could have accounted for dermal ischemia and the subsequent development of the scarring lesions.

Aged↗
PubMed2002

Primary subcutaneous follicular centre cell lymphoma with involvement of the galea: a case report and short review of the literature.

Primary cutaneous follicular centre cell lymphoma (FCCL) is a distinct subtype of cutaneous lymphoma that originates from germinal centre cells. Histologically, the disease is typified by a bottom-heavy infiltrate with a diffuse or follicular growth pattern situated in the mid or deep dermis. In some cases, the neoplastic infiltrate may involve the underlying subcutaneous tissue, but so far primary subcutaneous FCCL has not been reported. We report the first case of primary FCCL located primarily in the deep subcutis with extension into the galea and review the literature on primary subcutaneous B-cell lymphomas.

Female↗
PubMed2002

T-zone lymphoma with cutaneous involvement: a case report and review of the literature.

T-zone lymphoma (TZL) is a rare subtype of nodal peripheral T-cell lymphoma characterized by a clonal expansion of T-zone lymphocytes accompanied by a proliferation of other T-zone constituents. Non-specific cutaneous alterations are seen in about one-third of all cases, but specific cutaneous involvement is extremely rare. We present a case of TZL with secondary skin infiltration, review the literature on cutaneous manifestations of TZL and discuss the differential diagnosis of TZL.

Adult↗
PubMed2002

A case of Sézary's syndrome associated with granulomatous lesions, myelodysplastic syndrome and transformation into CD30-positive large-cell pleomorphic lymphoma.

Sézary's syndrome (SS) is a leukaemic variant of mycosis fungoides, a cutaneous T-cell lymphoma showing distinct clinical, histological, immunological, and genotypic features. We report a 10-year follow-up of a patient with SS exhibiting unusual features such as granulomatous skin lesions, transformation to a CD30-positive large-cell pleomorphic T-cell lymphoma, and development of myelodysplastic syndrome and review the cases of SS reported in the literature with these unusual and rare complications.

Fatal Outcome↗
PubMed2002

Superficial acral fibromyxoma: report of two cases.

Superficial acral fibromyxoma (SAFM) is a rare soft tissue tumor that has recently been delineated as a separate entity. We report 2 cases of SAFM and discuss its pathological features and differential diagnosis. Both patients had lesions on the toe. In 1 patient, the tumor was found after nail extraction, which had been performed for the treatment of onychomycosis, whereas in the other patient the tumor itself was the reason for seeking dermatological assistance. Biopsies from both cases demonstrated similar features. There was a moderately circumscribed, non-encapsulated tumor extending through the whole dermis. The neoplasm was composed of spindle and stellate cells with slight nuclear atypia arranged in a loose storiform, partly fascicular growth pattern. In 1 case, strands of cells with rather wavy nuclei were seen at the periphery of the tumor. Mitotic figures were scarce. The neoplastic cells were embedded in a myxoid stroma with increased numbers of small blood vessels and scattered mast cells. Immunohistochemically, the tumor cells showed weak focal positivity for CD34 and stained negatively for S-100 protein and alpha-smooth muscle actin. In 1 case epithelial membrane antigen (EMA) was negative, whereas in the second case focal expression of EMA by neoplastic cells was seen. Alcian blue staining revealed abundant mucinous material within the stroma. In conclusion, SAFM represents a distinct entity in the spectrum of cutaneous myxoid tumors. The differential diagnosis of SAFM includes various myxoid neoplasms and tumors with a predilection for distal parts of the extremities.

Aged↗
PubMed2002

Trichogerminoma: a rare cutaneous adnexal tumor with differentiation toward the hair germ epithelium.

In 1992, Sau and colleagues described 14 cases of a rare cutaneous adnexal tumor with differentiation toward the hair germ epithelium. All cases in their study displayed a unique constellation of histological features which allowed the authors to consider the neoplasm to be a distinct entity and to designate it as 'trichogerminoma' (TG). We present a case of an adnexal tumor identical to that described as TG and report the immunophenotypical features of this neoplasm for the first time. A biopsy from a 41-year-old man revealed a well-demarcated epithelial tumor composed of multiple lobules located in the deep dermis without connection to the overlying epidermis and surrounded by a fibrous pseudocapsule. The tumorous lobules were composed of uniform basophilic cells with vesicular nuclei, dispersed chromatin and prominent nucleoli showing no prominent peripheral palisading. Some of the lobules had the appearance of densely packed 'cell balls' with peripheral condensation of the tumor cells. The stroma showed a moderate number of fibroblasts and mast cells. Reticulum staining revealed fine reticulum fibers surrounding the tumor aggregates with accentuation of the 'cell balls'. Immunohistochemically, the tumor cells expressed AE1/AE3, CK5/8, CK5/6, CAM5.2 and stained negatively for CK20, CK7, calretinin, Lu-5 and Thomsen- Friedensreich antigen. There was no increase in the numbers of CK20-positive Merkel cells in the epidermis overlying the tumor; however, a few Merkel cells were scattered in some tumor lobules. In addition, we stained 6 trichoblastomas (TBs) and found a particular pattern of calretinin expression in this tumor which was not observed in our case of TG. We conclude that pathological features allow the delineation of TG as a distinct adnexal neoplasm. Histological differential diagnosis includes basal-cell carcinoma (pilar type), large nodular TB, trichoblastic fibroma, trichoepithelioma, tricholemmoma, pilomatricoma and matrical carcinoma.

Adult↗
PubMed2002

Primary cutaneous B-cell lymphomas and pseudolymphomas: review of histopathological features.

The terminology and classification of lymphoproliferative disorders in the skin remains a source of confusion for clinicians and pathologists. More than 25 types of malignant lymphoid neoplasms may involve the skin. These either arise primarily or represent secondary cutaneous involvement due to the spread of node-based lymphomas, other extracutaneous lymphomas or leukemias. In addition, there is a variety of cutaneous pseudolymphomatous reactions. This article addresses the histopathological features of primary cutaneous B-cell lymphomas and B-cell pseudolymphomas and presents a modern approach to the diagnosis of these lymphoid neoplasms.

Humans↗
PubMedDate not supplied

[Assessment of the significance of histological, immunohistochemical and clinical data in the diagnosis of lymphoproliferative skin diseases in conformance with a consensus by international experts].

The diagnosis of lymphoproliferative diseases of the skin remains a challenging problem in dermatology and requires a multidisciplinary approach. In our retrospective study two dermatopathologists independently reviewed 49 cases of skin lymphomas to determine the impact of diagnostic methods such as clinical examination, histological evaluation, and immunohistochemistry. The study was carried out in four independent review sessions consisting of (1) a review of histological sections only, (2) a review of immunohistochemical sections, (3) an introduction of the detailed clinical data, history, and staging information, and (4) and introduction of the follow-up. The agreement with the consensus was analyzed for every session, and statistics were calculated to evaluate the interobserver reliability. The agreement level with the consensus diagnosis was 18.8% for B-cell lymphomas and 12.5% for T-cell lymphomas after the first session, respectively, improved to 56.3% and 43.8% after the second session; to 100% and 79.7% after the third session, and to 100% and 85.9% after the forth one. The overall value for the diagnosis of T-cell lymphomas was 0.67 (good consensus) and for that of B-cell lymphomas was 1.00 (absolute consensus). The results of our study show that cutaneous lymphomas can be diagnosed reliably basing on the overall assessment of the clinical, histopathological, and immunohistochemical data. In some cases, however, molecular biologic methods may be required to diagnose cutaneous lymphomas properly.

Aged↗
PubMedDate not supplied

[Testicular teratoma with meningothelial elements].

A case of a mature adult teratoma of the right testicle in 34-year-old man is reported. Microscopically, well-differentiated gut and respiratory epithelium prevailed in the lesion. There were also epidermis and well-developed skin adnexa. In addition, a focus of a meningothelial cell proliferation containing psammoma bodies was detected. There were also a peripheral nerve and glial tissue adjacent to the meningothelial elements. The meningothelial cells were immunohistochemically positive for EMA and claudin and negative for S-100-protein, cytokeratins (AE1-AE3, CAM5.2), desmin, and chromogranin A. The glial tissue was positive for

Adult↗
PubMedDate not supplied

[Nephrogenic fibrosing dermopathy].

Nephrogenic fibrosing dermopathy is a rare disease with focal dermal thickening. A case is described of a male of 51 years after two renal transplantations for glomerulonephritis. He had a node in the anterior abdominal wall which was removed and studied. Immunohistochemically, there were positive dendritic cells and positive mononuclears, proliferation of dermal fibroblasts.

Dendritic Cells↗