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Biomedical subjects

D V Doyle

Publications and source records attributed to D V Doyle.

66 records · Page 4Linked to original sources
PubMed1982

Neutrophil surface-bound immunoglobulin--a feature of Felty's syndrome?

In a study of eight patients with Felty's syndrome, surface-bound immunoglobulin (IgG +/- IgM and complement) was demonstrated in all cases by a fluorescein-labelled antihuman globulin technique using paraformaldehyde-fixed neutrophils to prevent non-specific surface adsorption of immunoglobulin. The test was negative in control patients with rheumatoid arthritis alone. The neutrophil binding of immunoglobulin occurred in vivo and could not be reproduced with the patient's serum and normal neutrophils. The presence of alloantibodies due to previous pregnancy or transfusion can obscure this picture. A neutrophil autoantibody or cell-bound immune complexes may be the cause of this phenomenon, which may be a useful marker of Felty's syndrome in patients with rheumatoid arthritis.

Adult↗
PubMed1981

An articular index for the assessment of osteoarthritis.

An articular index was devised for the sequential assessment of patients with osteoarthritis (OA). Forty-eight joint units, chosen to reflect the characteristic pattern of the disease, were scored for tenderness on pressure or movement on a 4-point scale. Four observers examined patients to assess inter- and intraobserver error. The index was highly reproducible both within and between observers; intraobserver error was, however, significantly smaller. In a double-blind, cross-over trial the index was sufficiently sensitive to detect a statistically significant difference between the responses of patients with OA to an anti-inflammatory agent and to a simple analgesic. It is likely to be a useful addition to current methods of measurement in osteoarthritis.

Acetaminophen↗
PubMed1981

Sausage digit due to radish bacillus.

We wish to draw attention to a very characteristic but little known syndrome. An elderly woman presented with a 'sausage finger', rheumatological jargon used to describe diffuse swelling of the digit. This proved to be a proliferative tenosynovitis caused by an atypical mycobacterium, Mycobacterium terrae, or the radish bacillus.

Aged↗
PubMed1980

A practical method for the identification of particulate and crystalline material in paraffin--embedded tissue specimens.

The combination of light microscopy, low temperature micro-incineration of paraffin sections, and subsequent scanning electron microscopy (SEM), with X-ray energy spectroscopy (XES) has been shown to allow rapid and reliable identification of inorganic crystalline and particulate material in body tissues. Applications of this technique to hospital practice are illustrated and its potential in diagnosis and research are suggested.

Electron Probe Microanalysis↗
PubMed1979

Potassium permanganate induced calcergy: a model to study the effects of drugs on hydroxyapatite crystal deposition.

Hydroxyapatite crystal deposition is thought to play a role in the inflammatory episodes of osteoarthritis. A plaque of hydroxyapatite crystals was produced by local subcutaneous injection of a potassium permanganate solution. Transmission electron microscopy with X-ray energy spectroscopy was used to identify the crystal deposits as hydroxyapatite. The effects of dexamethasone, indomethacin, ethane 1-hydroxy-1, 1-diphosphonate (EHDP) and dichloromethylene diposphonate (Cl2MDP) on the development of the apatite plaque was studied. EHDP strongly inhibited the apatite deposition. Cl2MDP slowed the natural resorption of the apatite plaque. Dexamethasone and indomethacin failed to affect the crystal deposition process. The results suggest that EHDP could inhibit crystal deposition in the osteoarthritic joint and that Cl2MDP might have a role in slowing apatite crystal shedding from osteoarthritic cartilage and so reduce the synovitis seen in Osteoarthritis.

Animals↗
PubMed1977

Mixed crystal deposition in an osteoarthritic joint.

The case of a 72-yr-old woman with osteoarthritis of the shoulder, is described. A mixture of crystals of hydroxyapatite and calcium pyrophosphate dihydrate was identified in the joint tissues using analytical electron microscopy and infra-red spectroscopy.

Aged↗
PubMed1977

A clinical and prospective chromosomal study of yttrium-90 synovectomy.

Yttrium-90 synovectomy resulted in complete resolution of chronic knee synovitis in 40% of a group of 15 patients. These patients would have otherwise required surgical synovectomy. The number of chromosomal aberrations detected in 30 patients after yttrium-90 synovectomy showed a statistically significant increase over the pre-treatment analysis, and, following treatment, chromosomal damage was noted in nine patients who had no damage before treatment. The risk arising from this chromosomal damage is uncertain but, while the long-term implications of the chromosomal aberrations are investigated in those who have already been treated, this therapy should be reserved for the older patient.

Arthritis, Rheumatoid↗
PubMed1976

Renal disease in rheumatoid arthritis.

N-Acetyl-beta-D-glucosaminidase (NAG) is a sensitive indicator of renal damage. When the urinary NAG levels of 60 patients with rheumatoid arthritis (RA) were measured a highly significant difference was detected between the mean urinary NAG excretion of the patients with RA (341 +/- 294-92 nmol h-1 mg creatinine-1) and that of 60 matched controls (67-53 +/- 16-93 nmol h-1 mg creatinine-1). In 10 patients studied no correlation could be shown between the urinary NAG levels and levels in either serum or synovial fluid. A significant positive correlation was noted between urinary NAG excretion and disease activity as estimated by the Lansbury activity index, the Ritchie articular index, and the haemaglobin level. An abnormally raised urinary NAG excretion was detected in eight out of 20 previously untreated patients with RA, which suggested that the rheumatoid process may affect renal function.

Acetylglucosaminidase↗