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Biomedical subjects

D Ursing

Publications and source records attributed to D Ursing.

7 recordsLinked to original sources
PubMed1995

Simvastatin treatment of hypercholesterolemia in patients with insulin dependent diabetes mellitus.

The effects of 16 weeks therapy with the HMG-CoA reductase inhibitor Simvastatin 10-20 mg (n = 12) was compared to placebo (n = 13) in 25 euthyreoid males with insulin dependent diabetes mellitus and fasting total serum cholesterol above 6 mmol/l. Insulin dependence was defined as a glucagon stimulated C-peptide level less than 0.6 mmol/l. The study was placebo-controlled, double-blind with a parallel group design. Body weight, blood pressure, glycemic control as well as liver enzymes were unchanged and simvastatin was well tolerated by all patients. Ophthalmological slitlamp examination before and at the end of the study period did not show development of new lenticular opacities. Simvastatin decreased serum total cholesterol from 6.7 +/- 1.0 mmol/l (mean +/- SD) to 4.9 +/- 0.4 (p < 0.001 vs. placebo) and LDL-cholesterol from 4.6 +/- 0.7 mmol/l to 2.8 +/- 0.3 (p < 0.001 vs. placebo). HDL-cholesterol and triglycerides remained unaltered. A positive influence on the atherosclerotic process in patients with insulin dependent diabetes mellitus remains, however, to be proven.

Adult↗
PubMed1988

Lipoproteins and metabolic control in hypertensive type II diabetics treated with clonidine.

Twenty patients with type II diabetes mellitus and hypertension (WHO stages I and II) participated in a 3-month double-blind cross-over study to evaluate the effects of clonidine (75-300 micrograms daily) on blood pressure, glycemic control and plasma lipoproteins. Already after 1 month's treatment with clonidine the systolic and diastolic blood pressures had decreased, from 168/103 to 161/98 mmHg (p less than 0.01). Fasting blood glucose and HbA1c concentrations were unaffected by 3 months' treatment. Similarly, plasma lipid and lipoprotein concentrations remained unchanged throughout the study (i.e. mean high and low density lipoprotein cholesterol concentrations were 0.89 and 3.87 mmol/l on placebo vs. 0.90 and 3.98 mmol/l on clonidine). Adverse effects were mild and tolerable, and consisted mainly of dryness of the mouth. We conclude that clonidine lowers the blood pressure in patients with type II diabetes without any adverse effects on glycemic control or plasma lipoproteins.

Blood Glucose↗
PubMed1987

Lack of primary effect of sulphonylurea (glipizide) on plasma lipoproteins and insulin action in former type 2 diabetics with attenuated insulin secretion.

A double-blind, placebo-controlled investigation has been made into the effects of 8 weeks of glipizide treatment in diabetics previously classified as Type 2 but with subsequent attenuation of insulin secretion and thence maintained on exogenous insulin. Although all patients were exposed to therapeutic plasma concentrations of glipizide, fasting blood glucose, haemoglobin A1 and plasma lipoproteins (HDL, LDL, total cholesterol and triglycerides) did not show any consistent improvement following this treatment. It appears unlikely that SU (glipizide) has any primary effect on insulin action or on plasma lipoproteins. Its primary action is to augment insulin release and availability, so, its use should be restricted to Type 2 diabetics who retain insulin secretion.

Blood Glucose↗
PubMed1981

Antihypertensive effect and tolerability of two fixed combination of metoprolol and hydrochlorothiazide followed by a long-term tolerance study with one combination.

After a run-in period with metoprolol 100 mg b.i.d. 55 patients with essential hypertension grade WHO I and II were randomly allocated to a fixed combination of metoprolol 100 mg and hydrochlorothiazide 12.5 mg (group A) or 25 mg (group B) b.i.d for 12 weeks. Every fourth week blood pressure, heart rate and side effects were registered. After 12 weeks there was a significant fall in supine blood pressure from 172/105 mm Hg to 148/92 in group A and from 170/104 mm Hg to 152/96 in group B. Serum potassium fell significantly (from 4.4 to 4.0 mmol/l) in group B only. 4 patients had values between 3.5 and 3.2 mmol/l. Serum uric acid was unchanged in both groups. Side effects were few and mild to moderate in both groups but there was a tendency to more side effects in group B. After 6 months' follow-up, 51 patients on treatment with low dose combination showed no further change in blood pressure. 27 patients took part in an extended follow-up study to 15 months and 13 patients to 18 months. During the whole follow-up study there was no further change in blood pressure, laboratory values or side effects. The study has confirmed that a low dose of hydrochlorothiazide is as effective as a high dose when combined with metoprolol. Because of few side effects and good tolerability during long treatment we find that the low dose combination can be recommended in treatment of milk to moderate essential hypertension.

Adolescent↗
PubMed1978

Myoglobin.

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Evaluation Studies as Topic↗
PubMedDate not supplied

Insulin release in fasting man induced by impure but not by pure preparations of cholecystokinin.

Most preparations of cholecystokinin reported to release insulin have been impure. When highly purified preparations of extracted cholecystokinin and also the synthetic C-terminal octapeptide of the hormone became available for use in humans, we investigated their insulinotropic activity in comparison with a cruder preparation of cholecystokinin in 10 fasting non-diabetic subjects. The doses employed were 75 Ivy dog units, except for the synthetic C-terminal octapeptide of cholecystokinin that was given in a dose of 200 Ivy dog units to compensate for a shorter hawn every minute during 10 min after each injection, thereafter at intervals of 5 min. The mean plasma insulin level increased significantly, reaching a peak 4-5 min after iv injection of the cruder cholecystokinin preparation, but after the other two preparations the plasma insulin level was not significantly changed. The blood glucose level was not significantly changed by any of the preparations used. It is concluded that the plasma insulin peak seen in man after i.v. injection of the less highly purified preparation was due not to cholecystokinin but to some other agent present in this less pure preparation. The identity of this factor is discussed.

Adult↗