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Biomedical subjects

D Turini

Publications and source records attributed to D Turini.

At least 55 records · Page 3Linked to original sources
PubMed1988

Specific motor effects of capsaicin on human jejunum.

Capsaicin (1 microM) produced a biphasic effect on the motility of longitudinal muscle strips from human jejunum e.g. an initial inhibitory effect on nerve-mediated contractions followed by a delayed increase in motility. Neither effect was observed upon a second application of the drug, indicating desensitization, a proposed marker of the action of capsaicin on sensory nerves. Both substance P and neurokinin A produced a contraction of isolated human jejunum, while calcitonin gene-related peptide had a small and inconsistent inhibitory effect.

Adult↗
PubMed1988

Contractile response of the human isolated urinary bladder to neurokinins: involvement of NK-2 receptors.

The contractile response to substance P (SP), neurokinin A (NKA) and arginin-neurokinin B (Arg-NKB) (a water soluble analogue of NKB) was investigated in detrusor muscle strips from the dome of the urinary bladder obtained from patients undergoing total cystectomy for carcinoma of the bladder base. Spontaneous activity and response to nerve stimulation indicated that the material used in this study has characteristics similar to those described for 'normal' human detrusor muscle. All neurokinins induced a concentration-related contraction with sensitivity at nM concentrations and the following rank order of potency: NKA (90) greater than Arg-NKB (22) greater than SP (1). These findings indicate the involvement of NK-2 receptors in the contractile response of human detrusor muscle to neurokinins.

Aged↗
PubMed1988

Relaxation of isolated corpus cavernosum induced by smooth-muscle relaxant drugs. A comparative study.

Intracavernous injection of vasoactive substances are used in the treatment and investigation of impotence. We studied the effects induced by some pharmacological agents on strips of human erectile tissue. Specimens of corpus cavernosum were obtained from 16 men undergoing cystectomy or penectomy for bladder or penile malignancy. Strip preparations were mounted in thermostically controlled baths containing Krebs solution. Pharmacologic effects were monitored by means of an isotonic transducer. Papaverine was shown to be the substance able to cause the biggest relaxation effect. The authors compared the action of other drugs having a relaxant effect, studied the antagonist effects of epinephrine and dopamine on the pharmacologically relaxed preparations, and stressed that the relaxation of the erectile tissue has a determinant role in the appearance and maintenance of erection.

Adult↗
PubMed1988

Conservative surgical treatment of renal cell carcinoma: clinical experience and reappraisal of indications.

During a 14-year period 36 patients who presented with renal cell carcinoma underwent conservative surgical treatment. The patients were divided into 3 groups according to treatment indications and condition of the contralateral kidney: group 1 included patients with a solitary kidney or bilateral tumors, group 2 patients had a damaged contralateral kidney and group 3 patients were without abnormalities of the contralateral kidney. Cumulative 6-year survival rates were 58 per cent for group 1, and 90 per cent for groups 2 and 3 combined. The over-all cumulative 6-year survival rate was 74 per cent. Based on these data extension of the indication for conservative surgical treatment seems to be justified in patients who present with low stage tumors and partial or potential damage to the contralateral organ.

Adult↗
PubMed1988

Biological, diagnostic and therapeutic aspects of a case of renal cell carcinoma occurring with bladder and contralateral adrenal metastasis.

We report a case of renal cell carcinoma occurring with bladder and contralateral adrenal metastasis discovered preoperatively with computerized tomography. Surgical treatment consisted of radical nephrectomy, with preservation of the ipsilateral adrenal gland, contralateral adrenalectomy, and transvesical resection of the bladder neoplasm. The hypothesis for the mechanism(s) of spread and treatment modalities are discussed.

Adrenal Gland Neoplasms↗
PubMed1987

Galanin: a potent modulator of excitatory neurotransmission in the human urinary bladder.

Galanin (GAL) produced a concentration (0.3-100 nM)-related inhibition of the atropine-sensitive component of the contractions induced by field stimulation of detrusor strips from the dome of the human urinary bladder. GAL had an ED50 of 2 nM for the inhibition. The effect of GAL was prevented by atropine (1 microM) and was not seen when the strips were stimulated with a cholinomimetic or KCl. These data suggest a possible neuromodulator role of GAL in the human urinary bladder.

Aged↗
PubMed1987

Caval extension of renal cell carcinoma. Results of surgical treatment.

Twenty-eight patients with renal cell carcinoma extending to the vena cava underwent surgical treatment consisting of radical nephrectomy and removal of tumor thrombus, which was at the level of the renal veins in 23 cases, the hepatic veins in 4, and extending above the diaphragm in 1 case. In 7 patients lymph nodes were invaded, and 8 had both positive nodes and extrarenal tumor diffusion discovered at surgery. The mean survival was 41.7 months for patients with only venous extension of the tumor, 16 months for patients with positive nodes, and 10.2 months for those with both nodal and extrarenal tumor diffusion.

Adult↗
PubMed1987

Simultaneous bilateral adrenal involvement by renal cell carcinoma: experience with 3 cases.

We report 3 cases of renal cell carcinoma and synchronous bilateral adrenal metastases discovered preoperatively with computerized tomography and other imaging techniques. Surgical treatment consisted of radical nephrectomy through a transperitoneal approach, with adjunctive lower polar resection in a patient with bilateral renal tumors, and contralateral adrenalectomy. Subsequent steroid treatment was given.

Adrenal Gland Neoplasms↗
PubMed1986

Removal of renal cell carcinoma extending to the supradiaphragmatic vena cava with the aid of cardiopulmonary bypass.

A woman with renal cell carcinoma confined within Gerota's fascia but extending to the supradiaphragmatic vena cava was successfully treated with the aid of cardiopulmonary bypass. The approach was a subcostal chevron incision coupled with a midline sternotomy. The rationale and indications for aggressive surgery of renal cell carcinoma with massive caval extension are discussed.

Carcinoma, Renal Cell↗
PubMed1986

Intracavernous therapy in impotence after pelvic trauma. A preliminary study.

Pelvic trauma, especially when complicated by a posterior urethral disruption, may cause impotence in 50% of patients. The treatment of this kind of impotence has always been troublesome for the urologist. In fact penile prostheses or the revascularization procedures have sometimes been failures. We present a series of 6 patients with impotence after pelvic trauma managed by intracavernous injection of papaverine and we describe here the preliminary results obtained.

Adult↗
PubMed1984

Chronic total renal artery occlusion: a diagnostic challenge.

Chronic renal artery occlusion must be suspected whenever a moderate hypertensive patient over 50 years of age presents increase of blood pressure refractory to treatment, sometimes causing heart failure or stroke. This suspicion is reinforced by the presence of renal insufficiency and of anatomical and/or functional lateralization of renal damage at intravenous pyelography.

Adult↗
PubMed1983

Surgical repair of ureteral defects.

A nineteen year surgical experience with 35 patients requiring repair of ureteral defects is reported. Causes of ureteral damage are described, and the result of 18 patients treated with ileal ureter are compared with those of 17 cases where surgical procedures preserving urothelial continuity were used, such as bladder psoas hitch and renal autotransplantation. Significantly better results were observed with the latter techniques.

Adult↗
PubMed1982

Leiomyosarcoma of the kidney: report of two cases with common angiographic findings.

Two cases of renal leiomyosarcoma are described. At angiography both cases presented common findings consisting of: (1) central hypovascularity surrounded by peripheral tumor neovascularity and (2) oval-shaped areas that rapidly filled with contrast medium. This angiographic appearance, although not previously described in such tumors, cannot be claimed to offer a key to preoperative diagnosis because it may be found in the more common hypernephromas with central necrosis.

Adult↗
PubMed1982

Experience with ureterocalyceal anastomosis.

Experience with 10 cases of ureterocalyceal anastomosis is reported. Most cases involved scleroatrophic scarring of the pelvis after repeated stone surgery, and 1 case each for failed pyeloplasty, tuberculous stricture of the pelvis, transitional cell carcinoma of the pelvis and calyces, and ureteropelvic junction obstruction associated with renal malformation. Three patients had a solitary kidney. End-to-end ureterocalyceal anastomosis was performed in 5 patients; laterolateral in 1 case, and ureteropyelocalyceal anastomosis in the remaining 4. In 3 cases omentoplasty was also performed.

Adult↗
PubMed1982

Ureteral motility after renal autotransplantation.

Twelve kidneys were autotransplanted to the internal iliac vessels in 11 patients for the treatment of renovascular hypertension. The ureter had been left unresected in all but one case, where a transuretero-ureterostomy was performed. A radiographic study of the ureteral motility was obtained during the postoperative period recording images every 1.5 s with a spot-camera system. The ureters appeared to follow different courses, due to the different surgical procedures. In all but two cases the transport of urine was obtained through separate boluses, frequency and direction of peristalsis were within normal ranges, and significant dilation was never observed.

Humans↗