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Biomedical subjects

D Torre

Publications and source records attributed to D Torre.

At least 91 records · Page 5Linked to original sources
PubMed1989

Effect of rokitamycin on human polymorphonuclear leukocyte chemotaxis.

The effect of rokitamycin on human polymorphonuclear leukocyte (PMNL) chemotaxis was studied in vitro and in vivo. It was found that rokitamycin in vitro at a concentration of 20 micrograms/ml caused a diminution of PMNL migration, while at lower concentrations no significant effects on migration was observed. In in-vivo studies before and after the ingestion of rokitamycin by six healthy individuals, no change on PMNL chemotaxis was found.

Adult↗
PubMed1988

In vitro influence of charcoal on ciprofloxacin activity.

The effect of charcoal-containing media on ciprofloxacin (BAY o 9867) has been evaluated. The minimal inhibitory concentrations of ciprofloxacin are increased by the presence of charcoal, thus a correction factor has to be calculated to know the real efficacy of the drug, especially in life-threatening infections such as pneumonia due to Legionella spp.

Charcoal↗
PubMed1988

Effects of orally administered activated charcoal on ciprofloxacin pharmacokinetics in healthy volunteers.

Ciprofloxacin is a broad-spectrum antibiotic orally active against both gram-positive and gram-negative bacteria. Recent literature indicates that orally administered activated charcoal can alter the bioavailability of many drugs and in vitro studies have demonstrated an interaction with ciprofloxacin. To evaluate in vivo the effects of activated charcoal on ciprofloxacin pharmacokinetics, six healthy volunteers received, according to a cross-over design, either ciprofloxacin 500 mg alone or concomitantly 1 g activated charcoal. The coadministration of the latter drug did not influence any of the considered pharmacokinetic parameters. Activated charcoal at a clinically effective dose, therapeutically used in gaseousness, does not alter ciprofloxacin pharmacokinetics.

Administration, Oral↗
PubMed1988

[The problem of screening for HIV infection in mentally retarded institutionalized subjects].

Screening programs for the acquired immunodeficiency syndrome have been proposed to several categories of persons at increased risk for AIDS. On the other hand, it is still controversial if people with mental retardation may be candidates for mandatory screening. In our opinion, the reduced competence and diminished autonomy that characterize institutionalized mentally retarded subjects, it might be appropriate those who are uninfected from possible human immunodeficiency virus infection.

Acquired Immunodeficiency Syndrome↗
PubMed1988

Delayed-type hypersensitivity responses in mice treated with pertussis toxin and betamethasone.

Effects of pertussis toxin (PT) and betamethasone on delayed-type hypersensitivity (DTH) in mice were studied. When mice received PT (1 microgram/mouse) at the time of immunization or elicitation, a depression of DTH responses was observed. In addition, when mice received PT five days before and at the time of immunization, the DTH responses were suppressed. The administration of betamethasone along with PT at the time of immunization and elicitation caused an inhibition of DTH responses. These results suggest that PT depressed the DTH responses and that betamethasone suppressed such responses. Based on these findings, possible mechanisms by which PT and betamethasone affect DTH are discussed.

Animals↗
PubMed1987

Skin manifestations in infants with AIDS.

We have observed a peculiar skin manifestation that resembles cutis marmorata in three patients with AIDS and may be included among the several clinical aspects of AIDS in pediatric patients. One of the three patients died 4 months after the diagnosis. In an another patient, the skin lesion is still present 2 years after appearance.

Acquired Immunodeficiency Syndrome↗
PubMed1986

Effect of betamethasone in lungs of mice treated with lymphocytosis-promoting factor of Bordetella pertussis.

The role of betamethasone in the lungs of mice treated with lymphocytosis-promoting factor (LPF) was studied. Intravenous injection with 10 ng of LPF produced significant lymphocytosis and monocytosis five days later. Two groups were also treated with betamethasone: the first with daily administrations and the second at zero-time with LPF. Lymphocytosis was not as high as in the group treated only with LPF (P less than .05), and lymphocytosis was lower in the second group than in the first (P less than .05). In lungs of mice treated with LPF, lymphocytes accumulated relative to lymphoid organs such as the spleen, where a marked depletion was noted. Administration of betamethasone either with LPF or after one day did not cause accumulation of lymphocytes in lungs, whereas increased spleen cellularity was observed. These data were also supported by histological changes, i.e., diminished congestion and edema of the lung and reduction of mononuclear cells in parenchyma.

Animals↗
PubMed1986

Prevalence of antibodies to Legionella pneumophila and micdadei in hospitalized children.

217 children were studied by IFA technique to assess the incidence and prevalence of infections due to L. pneumophila and micdadei. The study was completed by a bacteriological environmental research. No acute infection was detected. Nevertheless 10.1% of all patients showed positive antibody titers. This percentage was 0 in children aged less than 1 year and reached 17.7% in children after 3. Most positive sera were due to a pooled antigen containing L. pneumophila serotypes 1, 2, 3. All environmental samples were negative. Our results demonstrate that our area has probably a low endemicity and that children are a low risk population. Nevertheless the absence of acute pulmonary pathology either during the period of investigation or at the anamnestic report seems to strengthen the reported possibility of infection without major pulmonary signs, with a course as an influenza-like syndrome or as an inapparent infection.

Antibodies, Bacterial↗
PubMed1986

Cryosurgery of basal cell carcinoma.

Cryosurgery is now a widely accepted modality for the treatment of basal cell carcinomas. This article presents a practical approach to using cryosurgery for this purpose in the dermatologist's office. Understanding the cryobiologic basis of cryosurgery is a prerequisite. Aspects of treatment covered include selection and use of appropriate equipment, indications and contraindications for specific tumors, preoperative preparation, various treatment technics with clinical and instrumental depth-dose monitoring, postoperative care, cure rate, and cosmetic and functional end results. The overall results obtained by cryosurgery compare favorably with those obtained by other modalities. Cryosurgery is the treatment of choice for some basal cell carcinomas and a satisfactory alternate treatment for others.

Biopsy↗
PubMed1985

[Therapy of brucellosis: clinical experience with a rifampicin- doxycycline combination].

After an examination of the data on brucellosis treatment in the literature, it is concluded that short-term courses of cotrimoxazole and tetracyclines give largely unsatisfactory results. In view of the synergism noted between rifampicin and doxycycline against in vitro and animal brucella, the association was given to 19 clinical cases and was found to be effective and easily handled. It is therefore concluded that this treatment is currently the best alternative to the classic streptomycin-doxycycline association.

Adolescent↗