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Biomedical subjects

D Tomlinson

Publications and source records attributed to D Tomlinson.

At least 55 records · Page 3Linked to original sources
PubMed1991

The changing direction of nystagmus in acute Menière's disease: pathophysiological implications.

The direction(s) and pathophysiologic basis of nystagmus during an acute attack of Menière's disease have been subject to much debate in the world literature. Clinical recordings from two patients whose nystagmus was captured near the very beginning of the acute vertiginous episode are presented. Previous clinical observations in Meniere's disease, experimental animal models concerned with initiation of peripheral nystagmus, and the phenomenon of recovery are discussed.

Acute Disease↗
PubMed1990

Sexual assault of men: a series.

The case records of five male victims of sexual assault presenting to two genito-urinary clinics are presented. The cases were chosen to illustrate the variety of presentations and possible sequelae of sexual assault of adult males.

Adolescent↗
PubMed1990

Joint planning. The day of reckoning draws high.

Joint planning: the very words seem to undermine the validity of the concept, so synonymous have they become with the bidding cycle for joint finance. Taken in a wider sense to encompass the development of all statutory and voluntary services to a priority client group, they conjure up the image of a most arduous and unmanageable task. Dylan Tomlinson and Andrew Nocon discuss the prospects for joint planning after "Caring for People".

Community Participation↗
PubMed1988

Community service for the mentally ill: what is the community?

In his study of the successive efforts of a DHA to plan for community services for the mentally ill, Dylan Tomlinson argues that there is a basic question which is necessary, but difficult, to answer: "In which neighbourhood is the pattern of ordinary social interaction such as to foster good relationships between 'ex patient' and other residents in a community?"

Community Mental Health Services↗
PubMed1971

Studies on the translocation of noradrenaline-containing vesicles in post-ganglionic sympathetic neurones in vitro. Inhibition of movement by colchicine and vinblastine and evidence for the involvement of axonal microtubules.

1. Methods are presented for studying axonal transport mechanisms in preparations of constricted hypogastric nerve/inferior mesenteric ganglia maintained in vitro for periods up to 48 hr. Under these conditions the ultrastructure of the tissue is excellently preserved.2. The proximo-distal movement of noradrenaline and noradrenaline storage vesicles in the non-myelinated axons of these preparations is inhibited by both colchicine (10 mug/ml.) and vinblastine sulphate (1 mug/ml.) whilst the movement of mitochondria appears to be unaffected.3. Neither colchicine nor vinblastine sulphate depletes accumulated dense-cored vesicles of their stores of noradrenaline.4. These drugs reduce the accumulation of noradrenaline and densecored vesicles against a constriction when they are in contact with the nerve trunks only, and are denied direct access to the nerve cell bodies in the ganglion.5. The only other morphological change that can be attributed to the action of colchicine and vinblastine is a marked reduction in the number of axonal microtubules.6. The experiments provide strong support for the view that the axonal system of microtubules is closely involved in the proximo-distal movement of noradrenaline storage vesicles within noradrenergic neurones. The microtubular system does not appear to be involved in mitochondrial movement.

Animals↗
PubMedDate not supplied

Proton MR spectroscopy and imaging of the brain in AIDS: evidence of neuronal loss in regions that appear normal with imaging.

Central nervous system involvement is increasingly being recognised as a common manifestation of the acquired immunodeficiency syndrome (AIDS), either as a direct effect of the human immunodeficiency virus, or as a result of secondary infection or malignancy. A subset of patients with clinical or psychometric evidence of CNS involvement have normal appearances on imaging. This report describes proton magnetic resonance spectroscopy (1H MRS) in two patients with AIDS and discusses the role of 1H MRS in providing a marker of neuronal loss in patients with normal or borderline imaging.

AIDS Dementia Complex↗
PubMedDate not supplied

Adult male victims of sexual assault: an underdiagnosed condition.

The records of 28 male victims of sexual assault were analysed retrospectively. The mean age at time of assault was 21.7 years and the mean number of assailants was 2.8. Sixteen victims (57%) reported skin or mucosal damage and 25 (89%) sustained penetrative anal intercourse. The threat of transmission of HIV was used by the assailant in 16 cases and sexually transmitted diseases, presumed consequent upon the attack, were found in 5 (18%). These observations suggest that male victims of sexual assault may be at particular risk of sexually transmitted infections, including HIV, and that efforts should be made to encourage them to come forward for help.

Adolescent↗
PubMedDate not supplied

Screening for cervical abnormalities in women with anogenital warts in an STD clinic: an inappropriate use of colposcopy.

An audit of the use of colposcopy in women with anogenital warts was performed. Fifty women attending a clinic for sexually transmitted diseases in a District General Hospital with anogenital warts were examined by cervical cytology and colposcopy for cervical infection by human papillomavirus (HPV) or epithelial abnormality indicating cervical intraepithelial neoplasia (CIN) or both. Collated results showed a high prevalence of both conditions in these 50 women; 20 (40%) had evidence of cervical infection by HPV and 11 (22%) epithelial abnormalities consistent with CIN 1 or 2. However, neither CIN 3 nor invasive disease was detected. Colposcopy in this setting was shown to be a specific but insensitive tool and its role in the routine management of women with anogenital warts at our institution is not warranted.

Adolescent↗
PubMedDate not supplied

The treatment of retinoblastoma: a case study.

Research in the treatment of retinoblastoma and multidrug resistance has led to new treatment protocols for children. This case study introduces information regarding a clinical trial for the treatment of intraocular retinoblastoma. It also highlights important nursing issues in the care of these children and their families.

Antineoplastic Combined Chemotherapy Protocols↗
PubMedDate not supplied

A new concept in radiology QA in a large setting.

Determining film quality has traditionally been carried out through review and evaluation of exam retakes. At best, such a system will tell which exam areas the technologist repeated most. Kaiser Permanente Northwest has 80 radiologic technologists and 30 radiologists who rotate through film reading. The program developed at Kaiser is directed toward general diagnostic film quality only and uses the services of two full-time quality assurance (QA) technologists. Working together, the radiologist and QA staff have created a standard of diagnostic image quality. A QA radiologist representative is available to work with the QA technologist if inconsistencies are raised. Every other month, a QA technologist makes a random selection for review of 50 exams performed by each technologist. These evaluations cover view rather than exam, with each view judged on its own merit. The purpose is to look for recurring problems in the technologist's performance. Copies of the review sheet go to each technologist's supervisor who forwards a copy to the technologist. Technologists can request help to understand why certain films meet or fail to meet quality standards. The QA technologists are available to give one-on-one help, and they also offer classes and demonstrations. In turn, radiologist fill out quality control (QC) slips as they read exams. The slips help to educate and correct specific problems, and are a direct communication link between radiologist and technologist. The QA program places importance on having the proper tools for taking quality films. The program also provides several levels of accountability although QA technologists are not responsible for its enforcement. Instead, they give feedback to supervisors who enforce performance levels. An appeals process is also in place. The program helps keep image quality acceptable to both hospital radiologists and customer requirements in the industry. In turn, the technologists use it to further their professional development.

Allied Health Personnel↗