Biomedical subjects
Publications and source records attributed to D Todorov.
The authors make a critical review of the methods, described in the literature for multiple samples of bile from rats under the conditions of a chronic experiment. They present their own method. The results from the follow-up of the dynamics in the bile cholinesterase activity in one of the rats canulated by this method are described.
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Some of the causes owing to which measurement of the gastric transmucous potential in animals and humans has failed to find practical application hitherto are listed. A method developed for operative agar bridges implantation within the abdomen of experimental animals is described. Several types of waves are observed in the electrograms of the gastric transmucous potential of rabbit and rats, obtained in the fashion outlined above. It is established that by changes in amplitude and by frequency, the type of waves just mentioned correspond to the peristalsis of the stomach. It is presumed that these waves are produced by changes in the gastric wall physical parameters upon contractions of the same.
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Tetrazolo-(5,4-a)-6-METHyl-uracil (compound VMI-502) and tetrazolo (5,4-a)-6-propyl-uracil (compound VMI-510) posses a marked sedative-hypnotic and analgesic action and a slightly expressed central skeletal muscles relaxant and anticonvulsant action. The analgesic (antinociceptive) action has been demonstrated by meens of 5 algesimetric methods. The compounds depress the pain reactions in case of stimulation of the superficial as well as of the deep nociceptors, too. Its analgesic action is about 3 times more intense then the action of codeine, about 20 times more intense then the action of amidopyrin and maetamizole, and about 2 times slighter then the action of morphine. The obtained results give the possibility of excluding the so called "false positive reaction". The studied compounds potentiate the analgesic action of the morphine and amidopyrine, applied in subanalgesic dose. It is assumed that by the mechanisme of his analgesic action the compounds VMI-502 and VMI-510 probably approach the non-narcotic analgesics.
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