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Biomedical subjects

D Todd

Publications and source records attributed to D Todd.

At least 217 records · Page 12Linked to original sources
PubMed1978

Malignant histiocytosis: report of five Chinese patients.

Five Chinese patients with malignant histiocytosis are described, the diagnosis being based on microscopic evidence of infiltration of at least three different tissues by noncohesive atypical phagocytic histiocytes, without total obliteration of normal architecture of those tissues. The mean age of the patients was 28 years; all presented with pyrexia (of 2 weeks to 2 1/2 years duration) and all had circulating neoplastic cells. Two patients showed remission with quadruple chemotherapy and one is alive and without symptoms 6 years after onset of his illness.

Adolescent↗
PubMed1978

Fatal cholangitis after endoscopic retrograde cholangiopancreatography in congenital hepatic fibrosis.

A patient with congenital hepatic fibrosis is described in whom portal hypertension with variceal bleeding was the predominant symptom, accompanied by a minor episode of cholangitis Endoscopic retrograde cholangiopancreatography disclosed intrahepatic bile duct strictures, tortuosity, and tubular dilatation, but not cystic dilatation as typical of Caroli's disease, in which cholangitis is known to be the predominant feature. Following the procedure, the patient developed fulminating cholangitis and septicaemia, and died despite surgical decompression of the biliary system.

Bile Ducts, Intrahepatic↗
PubMed1978

Comparison of antigens of pneumonia-associated mycoplasma species by gel diffusion.

Comparison of fluorocarbon-extracted antigens of six mycoplasma species by double immunodiffusion and counterimmunodiffusion techniques revealed a close reciprocal relationship among Mycoplasma dispar, M. ovipneumoniae, and M. hyopneumoniae. A lesser degree of cross-reaction was also demonstrated between these three species and M. hyorhinis and M. bovoculi. The interrelationships were more clearly demonstrated by double immunodiffusion than by counterimmunodiffusion.

Antigens, Bacterial↗
PubMed1977

Identification of a nondeletion defect in alpha-thalassemia.

The molecular defect that has been demonstrated in alpha-thalassemia is the deletion of the alpha-globin structural genes. Since thalassemias are composed of heterogeneous groups of disorders, other types of defects could also result in alpha-thalassemia. We studied a Chinese family in which analysis of the mode of inheritance of alpha-thalassemia-1 and hemoglobin-H disease suggests a lesion that is not due to structural-gene deletion. Molecular hybridization studies with synthetic radioactive DNA's complementary to alpha-globin mRNA sequences show that in addition to the usual deletion defect, a nondeletion defect produces the phenotype of alpha-thalassemia-1. The combination of the deletion and non-deletion defects results in hemoglobin-H disease and not homozygous alpha-thalassemia associated with hydrops fetalis.

Chromosome Deletion↗
PubMed1977

Adult Niemann-Pick disease--a case report.

A case is presented of the rare adult form of Niemann-Pick disease occurring in a Cantonese. The diagnosis was verified by biochemical analysis of the affected tissues.

Female↗
PubMed1977

Biochemical studies on a reovirus-like agent (rotovirus) from lambs.

Ten polypeptides were detected in double-capsid lamb rotavirus; four of these appeared to be associated with the outer capsid. Lamb rotavirus RNA, which consisted of 11 or 12 segments, differed from pig rotavirus RNA in the electrophoretic mibility of one of the genome segments.

Animals↗
PubMed1977

The molecular defects of alpha-thalassemia in the Filipino.

Molecular hybridization with synthetic radioactive DNA (cDNA) complementry to alpha globin mRNA sequences shows that, as in most other Southeast Asian populations, the alpha globin structural genes are deleted in Filipinos affected by the alpha-thalassemia syndromes. Thus, all 4 alpha-globin structural genes are deleted in homozygous alpha-thalassemia with hydrops fetalis, 3 and 2 structural genes are deleted in hemoglobin H disease and alpha-thalassemia-1 respectively.

DNA↗
PubMed1977

Aplastic anaemia: a study of prognosis and the effect of androgen therapy.

One hundred and twenty-nine Chinese patients with aplastic anaemia, were studied. In ten it was induced by drugs, one followed hepatitis and the remainder were of unkown cause. Mortality within the first six months was 47.3 per cent. Features associated with poor prognosis included a short duration of symptoms of three months or less, neutropenia of less than 0.5 x 10(9)/l and severe thrombocytopenia. On the other hand, some preservation of erythroid activity of the bone marrow was associated with long survival. Remission occurred in 47 patients and this was associated with androgen therapy in 33. Remission was complete in 18 and partial in 29. In the latter group, persistent thrombocytopenia was the main abnormality and treatment with calusterone led to an increase in platelets although the effect was not sustained after its withdrawal. Hepatotoxicity was seen in 16.0 per cent of patients treated with androgens and this occurred even with non-17alpha-alkylated compounds. It is concluded that androgen therapy was useful and should be started as early as possible after diagnosis. Hepatic intolerance to androgens may be an indication for bone marrow transplantation.

Adolescent↗
PubMed1976

Drug-induced haemolysis in glucose-6-phosphate dehydrogenase deficiency.

People with the variants of glucose-6-phosphate dehydrogenase (GPD) deficiency common in the southern Chinese (Canton, B(-)Chinese, and Hong Kong-Pokfulam) have a moderate shortening of red-cell survival but no anaemia when they are in the steady state. With a cross-transfusion technique, primaquine, nitrofurantoin, and large doses of aspirin were found to aggravate the haemolysis while sulphamethoxazole did so only in some people. Individual differences in drug metabolism may be the reason for this. Many commonly used drugs reported to accentuate haemolysis in GPD deficiency did not shorten red-cell survival.

Aspirin↗
PubMed1976

Characterization of pig rotavirus RNA.

Pig rotavirus was purified from faeces. The RNA from this virus was resistant to pancreatic ribonuclease, indicating that it is double-stranded. When electrophoresed on polyacrylamide-agarose gels, pig rotavirus RNA migrated as 9 bands comprised of 11 or 12 RNA segments with a total mol. wt. of approx. 11 X 10(6). Co-electrophoresis experiments revealed that the RNAs from the pig virus and two isolates of the calf rotavirus were indistinguishable.

Animals↗
PubMed1975

Haemolysis complicating viral hepatitis in patients with glucose-6-phosphate dehydrogenase deficiency.

Out of 20 patients with viral hepatitis whose glucose-6-phosphate dehydrogenase (G-6-PD) levels were normal, 14 had clinical evidence of a mild to moderate degree of haemolysis but in all the patients studied the half life of chromium-51-labelled red cells was shortened. Out of 18 viral hepatitis patients deficient in G-6-PD 17 had clinical evidence of haemolysis, and in eight this was more severe than in the group with normal G-6-PD values. Massive intravascular haemolysis occurred in four, three of whom died. The massive haemolysis was attributed to the presence of additional drug-induced oxidative stress to the G-6-PD-deficient red cells.

Alanine Transaminase↗
PubMed1975

Determination of the molecular weight of bovine enterovirus RNA by nuclease digestion.

The mol. wt. of a [32P]-labelled bovine enterovirus RNA has been determined by digesting with pancreatic RNase and separating the resulting oligonucleotides using a two-stage fractionation method on DEAE-Sephadex in 7 M-urea at pH 7-6 and pH 3-0. We have estimated the number of nucleotides as 8612 plus or minus 55. This corresponds to a mol. wt. of 2-93 plus or minus 0-02 X 10-6 which is in aggrement with estimates obtained by sedimentation and gel electrophoresis techniques.

Animals↗