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Biomedical subjects

D Thompson

Publications and source records attributed to D Thompson.

At least 415 records · Page 23Linked to original sources
PubMed1981

Calorie-protein deficiencies and the immune response of the chicken I. Humoral immunity.

How dependent is the chicken on the calorie (C) and amino acid (AA) levels of the diet? This question was addressed by formulating diets that were two-thirds deficient in C and AA. Feeding the one-third C-one-third AA, one-third C and one-third AA diets for 5 weeks, in general reduced the primary response to 5% sheep red blood cells (SRBC) but not to .5% SRBC. The C/AA deficient birds were returned to a basal diet at 5 weeks and three weeks later reimmunized with SRBC. The secondary response, immunoglobulin G (IgG) titer, of the latter birds after 3 weeks on a basal diet was significantly lower than controls. Total serum protein was significantly depressed during the feeding of one-third AA diet. Transferrin, IgG, and IgM were not affected while albumin was significantly reduced. Gain in body weight was reduced in all groups receiving the C/AA deficient diets. Three weeks after repletion, all groups gained equally.

Animals↗
PubMed1981

Simultaneous markers for fluid and solid gastric emptying: new variations on an old theme: concise communication.

Radiotracer techniques for the assessment of gastric emptying have become popular in the past 6 yr. A new double-nuclide technique, for the simultaneous tagging of the solid and fluid phases, is described. Technetium-99m sulfur colloid (Tc-99m SC) is used in a manner similar to that described by Meyer and colleagues, but the new technique does not involve the use of live chickens, a significant advantage over the earlier procedures. Several fluid-phase radionuclides were tested to be used in conjunction with the Tc-99m SC. Indium-111 DTPA was found to be the only compatible fluid-phase agent. This new double-tracer technique promises to be safe, economical, simple, and physiologically sound.

Animals↗
PubMed1980

Glycosylation and acetylation of hemoglobin in infants of normal and diabetic mothers.

The minor hemoglobins, which are formed post-translationally by acetylation or glycosylation, were studied in cord blood from 34 newborn infants. There were 9 normal infants, 8 infants of gestational (chemical) diabetics, and 17 infants of insulin-dependent diabetics. Among these groups, no significant differences in the acetylated fetal (FI) or other minor hemoglobin fractions were found by either isoelectric focusing in polyacrylamide gels or chromatography on DEAE-cellulose columns. These studies emphasize the technical limitations of detecting small amounts of glycosylated hemoglobin in newborns. The biological implications of the acetylated fetal hemoglobin fraction remain obscure.

Acetylation↗
PubMed1979

Is there a fetal gasoline syndrome?

Two children from a small Amerindian community presented with profound retardation, initial hypotonia progressing to hypertonia, scaphocephaly, a prominent occiput, poor postnatal head growth, and additional minor anomalies. Abuse of gasoline by inhalation was a widespread problem in the community, and gasoline inhalation during the pregnancy could be documented in both of the pregnancies. We are raising the question as to whether inhalation of gasoline during pregnancy may be teratogenic in humans.

Adolescent↗
PubMed1979

Two aminophylline preparations in nocturnal asthma.

In a double-blind trial the effects of aminophylline suppositories and slow-release aminophylline tablets were compared with similar placebo preparations in nine patients whose complaint was asthma which woke them from sleep at night. Forced expired volume in one second (FEV1) was measured in each patient at three-hourly intervals from 1900 hours to 0700 hours on four separate nights, the preparation being administered immediately after the 2200 hour measurement. On the nights when a placebo was administered the FEV1 showed a statistically significant fall between 1900 and 0400 hours. Aminophylline had a statistically highly significant effect in reducing or preventing this fall, suppositories and tablets being equally effective in this single-dose study.

Adult↗
PubMed1978

Haemodynamic effects of buprenorphine after heart surgery.

The effect of buprenorphine on the cardiovascular system was examined in 11 patients during the period of reduced cardiac reserve after open-heart surgery. Within 10 minutes of giving the full analgesic dose (5 microgram/kg) intravenously the mean heart rate had fallen significantly by six beats/min. Although in two patients the mean arterial pressure fell by 24 mm Hg, there was no overall change in mean arterial pressure, cardiac output, or peripheral resistance. In a further six patients buprenorphine was used successfully as the sole analgesic after open-heart surgery. Buprenorphine appears to be safer than morphine for use in patients with reduced cardiac reserve and is of similar analgesic efficacy.

Adult↗