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Biomedical subjects

D Telles

Publications and source records attributed to D Telles.

5 recordsLinked to original sources
PubMed2000

Prevalence of noncarious cervical lesions and their relation to occlusal aspects: a clinical study.

PURPOSE: The purpose of this study was to assess noncarious cervical lesions in young patients and to establish a possible relation with occlusal aspects. MATERIALS AND METHODS: Forty-eight dental students (28 males; 20 females) between the ages of 16 and 24 years, were investigated to verify the presence of noncarious cervical lesions and their relation to some occlusal aspects. The assessment involved a questionnaire, clinical examinations, and model analysis. RESULTS: The results indicated that the lower first molars (21.3%), the upper first molars (16.0%), the upper first premolars (12.8%), the lower first premolars (11.7%), and the lower second premolars (11.7%) were the teeth most affected by the lesions. Age was a significant factor with respect to the presence of lesions; the students with noncarious cervical lesions were older than the students who showed no lesions. Among the 79 teeth exhibiting lesions, 62 (78.5%) showed wear facets. In the group with lesions, the mean, per subject, was 15.0 teeth with wear facets, whereas in the group without lesions the mean was 10.8 teeth with wear facets per subject, suggesting that occlusal stress has some effect on lesion development.

Adolescent↗
PubMed1984

Development of topical BAPN delivery system for acute spinal cord injury in dogs.

Topical sustained release of various medications by a subdurally implantable device at the site of spinal cord injury is considered advantageous in the treatment of early symptoms of tissue damage. A typical case is the interference with collagenous scar by beta-aminopropionitrile, inhibiting collagen polymerization. Four materials, silicone, polyethylene, polytetrafluoroethylene (PTFE), and polyacrylonitrile-based hydrogel were evaluated for biocompatibility in subcutaneous implantations. The hydrogel, the least reactive, was then compared with silicone sheets as subcural implants. The histology favored the hydrogel as the most inert material, which was then used for the construction of soft, pliable pouches, releasing the drug through the hydrated wall at a rate controlled by an osmotic pump.

Aminopropionitrile↗
PubMed1980

Chronic reversible cerebral ischemia: evaluation of a new baboon model.

The authors describe their experience with a baboon model of reversible cerebral ischemia. Middle cerebral artery occlusion was achieved by external compression with an implantable, inflatable balloon cuff in awake, unanesthetized baboons. Selective cerebral angiography confirmed consistent, reliable occlusion. Computed tomography demonstrated early density changes after ischemia, which were reversible with reperfusion. Neurological evaluation demonstrated a "recruitment response" of increasingly persistent deficit with repeated occlusion. Permanent deficits were noted after extensive angiography during periods of occlusion. This was accompanied by the dropout of small vessels in the middle cerebral artery distribution. The results of pathological examinations were consistent with the clinical examinations. No gross or microscopic changes were noted after repeated occlusions that caused deficits like those of transient ischemic attacks. Consistent infarctions were noted in animals with permanent deficits after permanent occlusion or after repeated occlusion and extensive angiography.

Animals↗
PubMed1980

Intimal cellular response to microvascular anastomosis.

End-to-end and end-to-side anastomosis was performed on 1--4 mm diameter arteries and veins of dogs using 9--0 suture and microvascular technique. After peraortic in-vivo glutaraldehyde perfusion fixation was performed, specimens were immersed in fixative and later removed for SEM examination of intraluminal surfaces. Platelet and leucocyte aggregation was seen at 24 hours at sites of endothelial disruption. Consecutive stages of neoendothelialization were seen at intervals up to 6 months. Abnormal intimal surfaces are described at sites of high flow or jet stream turbulence in arteriovenous shunts or end-to-side arterial anastomosis. If stenosis of the lumen does not occur, intimal healing and 100% patency rates can be expected.

Animals↗