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Biomedical subjects

D Taylor

Publications and source records attributed to D Taylor.

At least 631 records · Page 35Linked to original sources
PubMedDate not supplied

The surgical management of nontraumatic ectopic lenses.

We report the results of limbal lensectomy for ectopia lentis in 50 eyes of 30 children over a period of 7 years. The reasons for surgery were poor visual acuity in 47 eyes and dislocation of the lens into the anterior chamber in three. Best-corrected visual acuity improved in all except two patients, both of whom had glaucoma: in one (with an unusual syndrome), a vitreous hemorrhage occurred that resulted in light-perception-only vision; in the other, a persistent uveitis developed that eventually required secondary vitrectomy. Visual acuity was unchanged in two patients. Peaked pupil occurred in seven. We conclude that, unless there are associated ocular diseases, limbal lensectomy in childhood ectopia lentis effectively improves visual acuity with few complications.

Child↗
PubMedDate not supplied

Student preparation in managing violence and aggression.

Nurses have suffered at the hands of violent patients and visitors for a long time, and incidents are on the increase. This article demonstrates the necessity of protecting nurses by training them to protect themselves when students.

Aggression↗
PubMedDate not supplied

From QA to CQI and TQM.

Explore the source record for details and available documents.

Education, Nursing, Continuing↗
PubMedDate not supplied

Quantification of ovine bone adaptation to altered load: morphometry, density, and surface strain.

Mechanical loading in the sheep proximal radius was increased by ulnar osteotomy (Group O), decreased by Steinmann pinning (Group P) and unaltered in sham operated controls (Group C). A series of intravenous fluochromes was given to label bone formation and the adaptive response was measured at intervals up to 24 weeks. Surface strains, measured in an in vitro rig, were reduced in Group P and increased significantly in Group O. Cross-sectional area (CSA) peaked in all groups at 6 weeks consistent with a regional acceleratory phenomenon (RAP) and the formation of fibrolamellar bone of low density. In Groups C and P the extent of the RAP was related to the degree of operative trauma and the newly-formed bone was subsequently resorbed. In Group P, CSA fell below control levels suggesting negative adaptation. The increase in area was sustained in Group O and bone density increased due to mineralisation and infilling. Periosteal labelling of the scaffold of parallel-fibred bone peaked at 10 weeks, followed by labelling of lamellar bone filling the gaps in the structure. This adaptive response reduced surface strains to near normal levels by 24 weeks in Group O. Positive adaptation was distinguished from the non-specific RAP due to surgical trauma. The adaptive response is both 'intelligent', in that it utilises and adds to the RAP, and accurate, as no further increase in cross-sectional area was required after 6 weeks.

Animals↗
PubMedDate not supplied

Distribution of m-IBG in nude mice bearing LAN-5 neuroblastoma xenografts and in vitro cell culture.

BACKGROUND: Neuroblastoma is the commonest extra-cranial solid tumour of childhood and has a poor clinical outcome in patients with disseminated disease. Animal xenografts of this tumour offer a useful method of studying new diagnostic and therapeutic strategies for the tumour, prior to consideration of clinical trials. METHODS: 131I m-IBG was injected into nude mice bearing xenografts of the human neuroblastoma line LAN 5 in several sites. Animals were sacrificed at 24 (n = 6) and 48 hours (n = 5) and the biodistribution of the agent as well as uptake into the xenografted tumours was determined in a gamma well counter. In-vitro uptake of m-IBG into suspensions of LAN 5 cells was also determined in order to confirm the animal studies. RESULTS: There was no preferential accumulation of m-IBG in the xenografted tumours in any of the sites considered. Similarly, the in-vitro uptake of m-IBG showed the typical Michaelis-Menten kinetics of simple diffusion with no evidence of active uptake. CONCLUSIONS: The human neuroblastoma line LAN 5 failed to enrich m-IBG in either the xenograft or in-vitro situation. This may be related to the poor degree of differentiation of the tumour as evidenced by its unusual ease of growth in the sub-cutaneous site.

3-Iodobenzylguanidine↗
PubMedDate not supplied

NCTR computer systems designed for toxicological experimentation. II. Experiment start-up system.

The Experiment Start-Up System (ESS) developed and implemented at the National Center for Toxicological Research constructs models from information contained in experimental protocols. These models may then be used to project resource requirements and related schedules. Each experimental model provides information from which management can determine the raw resources such as quantity of food, water, bedding, cages, animals (sex, strain, species), chemical, facilities, and manpower needed for conducting the experiment. Based upon this information, management can determine if the required resources are available and determine the most feasible "start" date for the new experiment. In addition, the information provided by the experimental model assures the Principal Investigator that the protocol requirements are thoroughly understood by participating technical support groups and that quality control elements of the ESS and other integrated systems will provide a means for accurately monitoring the experiment.

Computers↗
PubMedDate not supplied

A pilot study of pain, analgesia use, and pulmonary function after colectomy with or without a preoperative bolus of epidural morphine.

OBJECTIVE: To determine whether patients who received a preoperative bolus of epidural morphine plus postoperative parenteral analgesia had less pain and better pulmonary function over the first 2 days after a colectomy than patients who received postoperative parenteral analgesia alone. DESIGN: Repeated measures, quasi-experimental, random assignment. SETTING: Northeastern general hospital. SUBJECTS: Thirteen patients were randomized to receive parenteral with (n = 6) or without (n = 7) epidural analgesia. OUTCOME MEASURES: Indicators of pain (intensity of pain and pain-related distress, intensity of words used to describe pain, intramuscular-equivalent amount of morphine administered, duration from start of surgery to first request for analgesia) and pulmonary function (forced expiratory volume in one second FEV1], forced vital capacity [FVC], inspiratory capacity [IC], peripheral oxygen saturation [SaO2] values). MEASUREMENT: Indicators of pain and pulmonary function were obtained the day before surgery, approximately 6 hours after surgery, and the first two mornings after surgery. RESULTS: Six hours after surgery, patients in the epidural group had less pain (p = 0.0177) and related distress (p = 0.0303) and greater FVC (p = 0.0303) and FEV1 (p = 0.0025) than patients in the no-epidural group. On the first postoperative morning, patients in the epidural group had less distress related to pain (p = 0.0350) but similar respiratory rates and spirometry values. Inspiratory capacity was not statistically different but was always larger in the epidural group. Of patients who breathed room air, SaO2 was higher in the epidural group over the first two postoperative days (p = 0.0286 each occasion). Patients in the epidural group received their first on-demand analgesic an average of 30 hours after the start of surgery compared with 6 hours for patients in the no-epidural group (p = 0.0022). There were no significant differences in the total number of words used to describe the type of pain, and both groups described the pain with fewer words than expected on the first and second mornings after surgery. CONCLUSIONS: Results should be confirmed through study of a larger sample with the hypothesis that pain relief, selected aspects of pulmonary function, and peripheral oxygenation may be superior for patients who receive a preoperative bolus of epidural analgesia for abdominal surgery.

Adult↗