Search PubMed⌕ Search

Biomedical subjects

D Tarin

Publications and source records attributed to D Tarin.

At least 109 records · Page 6Linked to original sources
PubMed1979

Aneurysm of left ventricle secondary to bacterial endocarditis.

Three cases are described of aneurysms of the area of fibrous continuity between the aortic and mitral valves, each associated with infective endocarditis of the aortic valve. In two cases surgical treatment was successful, one of these having been diagnosed by angiography prior to operation. The other case was discovered only at autopsy, but the histologic findings showed the lesion to be a true aneurysm. Although some cases have been successfully managed by operation, most have proved fata. These cases and the previous successes illustrate the potential value of urgent operation.

Adult↗
PubMed1978

Diagnosis and management of obscure gastrointestinal bleeding.

Twelve consecutive patients presenting with unexplained recurrent gastrointestinal bleeding were investigated by selective visceral angiography. A cause for the bleeding was shown in all 12 cases, and in eight the lesion responsible was diagnosed radiologically as an area of angiodysplasia. Abnormal areas were pinpointed by fluoroscopy and examination of the resected bowel with a dissecting microscope after injecting the vessels with barium. Histologically these areas had various microvascular abnormalities. Angiodysplasia is a useful descriptive radiological term, but does not seem to represent a single pathological entity.

Adult↗
PubMed1976

Tissue and hepatic subcellular distribution of liposomes containing bleomycin after intravenous administration to patients with neoplasms.

1. Liposomes containing 111In-labelled bleomycin were injected intravenously into two patients. One patient had a hepatoma and the other had secondary adenocarcinomatous deposits in the liver. 2. The tissue distribution of 111In was determined by whole-body scanning and by measurement of the radioactivity in organs at autopsy. 3. Scans in vivo and post-mortem measurement of radioactivity indicated that liposomes accumulate predominantly in the liver, but that there is no selective uptake of liposomes by the malignant tissue. 4. The subcellular distribution of radioactivity in the liver was measured 90 min after injection by fractionation of percutaneous liver biopsies on sucrose density gradients. 5. Radioactivity within the liver was concentrated in lysosomes. 6. Electron microscopy of tissue obtained before the administration of liposomes revealed particles morphologically indistinguishable from liposomes in hepatoma cells and hepatocytes.

Adenocarcinoma↗
PubMed1975

Transfilter studies on neural induction in the newt.

In order to study the transmission mechanism of neuralising signals during primary embryonic induction, the interacting components (competent newt gastrula ectoderm and dorsal lip tissues) were separated by filter membranes of varying pore size. Nuclepore filters with nominal pore size from 0.1 to 8 mum were employed and the neuralising effect was shown to traverse all of these membranes. Electron microscopic examination did not reveal any cytoplasmic processes in the pores and the authors conclude that the morphogenetic signals are carried by transmissable compounds rather than through direct cytoplasmic contacts.

Animals↗