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Biomedical subjects

D Talbot

Publications and source records attributed to D Talbot.

160 records · Page 9Linked to original sources
PubMedDate not supplied

Influence of removal from occupational lead exposure on blood and saliva lead concentrations.

Samples of total blood and unstimulated mixed saliva were obtained from 5 male workers occupationally exposed to lead at various time intervals after removal from their work environment. Initial blood lead concentrations were elevated in all workers and then slowly decreased upon removal. Lead concentrations in saliva fell much more abruptly than those in blood, the saliva half-lives being estimated at 5-7 days. Temporary return to work in 2 workers resulted in relatively marked increases of salivary lead concentrations. These results suggest that salivary lead is closely related to recent lead exposure.

Environmental Exposure↗
PubMedDate not supplied

Gas chromatographic analysis of bromophenylmercapturic acids in urine.

A gas chromatographic assay specific for the analysis of bromophenylmercapturic acids in urine is described. The mercapturic acids are first hydrolyzed to form bromothiophenols, which are acetylated, extracted into dichloromethane, and analyzed by gas chromatography with a flame ionization detector. Using samples from rats and mice treated with bromobenzene, the authors make a comparison between this specific method and a nonspecific assay for the determination of total thioethers in urines.

Acetylcysteine↗
PubMedDate not supplied

Radioimmunoassay of buprenorphine in urine: studies in patients and in a drug clinic.

A radioimmunoassay kit (DPC buprenorphine double antibody) was evaluated with clinical samples and samples from a drug clinic. Urine samples were collected over a 2-day period from 5 hospital in-patients receiving sublingual buprenorphine, 400 to 2000 micrograms/day, for the relief of chronic pain. Samples were measured before and after enzymatic hydrolysis. Urine buprenorphine concentrations were measurable at all doses studied (minimum value 5.6 ng/mL) and were greater with larger doses. The increase in concentration after hydrolysis averaged 49% and was similar for all doses studied. The authors conclude that the method has extensive cross-reactivity with glucuronides of buprenorphine and its metabolites and that samples may be analyzed without prior hydrolysis. The prevalence of buprenorphine use in 97 patients attending a drug clinic was also studied. Sixty (62%) had measurable urinary buprenorphine concentrations of 1 ng/mL or more by direct assay. The buprenorphine users were significantly younger and reported significantly greater use of opiates than nonusers.

Adult↗
PubMedDate not supplied

Renal transplantation: origins and future.

Renal transplantation from its first successful operation in 1954 has become the preferred treatment option of patients with renal failure. The success of this recent development is followed in this article which tabulates surgical, tissue typing and immunosuppressive advancement. This success has produced other problems notably chronic rejection, posttransplant lympho-proliferative disease and donor shortage. The solutions to these problems are discussed, together with a hint of what is to come in the future.

Animals↗
PubMedDate not supplied

Acute appendicitis presenting with surgical emphysema and pneumomediastinum.

A case is reported of a young man presenting with abdominal pain and surgical emphysema of the neck. A chest x-ray revealed pneumomediastinum but other investigations excluded oesophageal rupture. He was found to have a complicated acute appendicitis. The history and likely causes of this unusual presentation of a common complaint are reviewed.

Adolescent↗
PubMedDate not supplied

A pharmacological alternative for treatment of haemorrhage from a hiatus hernia gastric ulcer.

Haematemesis in the elderly patient is a life-threatening condition. When the degree of blood loss is severe enough to warrant intervention by surgery or endoscopic means, the risk is even greater. We describe such a case, where treatment was further complicated as the bleeding point was in a hiatus hernia. The bleeding was successfully controlled by non-invasive means using an infusion of a somatostatin analogue.

Aged↗
PubMedDate not supplied

Treatment of adult pyloric stenosis: a pharmacological alternative?

Patients presenting with gastric outlet obstruction require investigation and treatment by surgery or balloon dilatation. This paper presents three cases of classic pyloric stenosis due to long-standing scarring from peptic ulceration. All cases were planned for active intervention but all settled, while investigations were in progress, with omeprazole. This would suggest that there are increasing numbers of such patients who are temporised with this treatment but may present again with refractile pyloric stenosis.

Aged↗