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Biomedical subjects

D T Wigle

Publications and source records attributed to D T Wigle.

At least 37 records · Page 2Linked to original sources
PubMed1986

Risk factors for postneonatal mortality: results from a record linkage study.

A population-based computer record linkage of infant births and deaths was conducted for 1978 and 1979 covering Canadian provinces. Birthweight was inversely related to risk of postneonatal death for all causes examined, including accidental deaths. Length of gestation was inversely associated with risk, but the strength of the relationship was much weaker than that noted for birthweight. A logistic regression model was used to assess the effects of variables, as reported on birth certificates, on postneonatal mortality. Maternal age less than 25 years, unmarried marital status and one or more previous births were all statistically significantly related to increased risk.

Adult↗
PubMed1985

Risk factors for perinatal mortality in Canada.

A population-based computer record-linkage study of infant births and deaths in 1978 and 1979 in eight Canadian provinces (Quebec and Newfoundland were excluded) was undertaken to permit analysis of perinatal mortality in relation to maternal and infant characteristics. Perinatal mortality rates were significantly higher in nonurban than in urban areas (p less than 0.05). A logistic regression model was used to assess the effects on perinatal mortality of variables reported on birth and stillbirth records. This model included length of gestation, infant's birth weight and sex, number of previous births and number of previous stillbirths as well as an interaction term for length of gestation and birth weight. For early-neonatal mortality, odds ratios over 8 were observed for birth weight less than 2500 g or gestation less than 35 weeks. About 75% of early-neonatal mortality was attributable to low birth weight or fetal immaturity. Greater emphasis should be placed on the prevention of low birth weight.

Birth Weight↗
PubMed1984

Tobacco smoke in the workplace: an occupational health hazard.

Tobacco smoke, which contains over 50 known carcinogens and many other toxic agents, is a health hazard for nonsmokers who are regularly exposed to it while at work. Involuntary exposure to tobacco smoke annoys and irritates many healthy nonsmokers. Serious acute health effects are probably limited to the one fifth of the population with pre-existing health conditions that are aggravated by exposure to tobacco smoke. The consequences of long-term exposure include decreased lung function and lung cancer. Existing air quality standards for workplaces do not directly specify an acceptable level for tobacco smoke. The evidence on the composition of tobacco smoke and on the health hazards of involuntary exposure suggests that there may not be a "safe" level for such exposure.

Acrolein↗
PubMed1984

Recent trends in incidence rates of pleural mesothelioma in British Columbia.

A total of 64 cases of pleural mesothelioma were reported in British Columbia between 1973 and 1980, 54 in males and 10 in females. There was a significant (p less than 0.05) increase in the incidence among males. The overall incidence rates were 4.9 and 0.9 per million person-years for males and females respectively. The age distribution of the cases was roughly exponential up to age 70 years. Almost all of the cases were clustered in Cowichan Valley, Capital and Greater Vancouver counties, where there was a high level of shipbuilding activity 30 to 40 years ago. The increased incidence in males may be related to this activity, which involved exposure to asbestos.

Adult↗
PubMed1982

Uterine cancers in Alberta: trends of incidence and mortality.

Death certificates were reviewed for the 543 Alberta women who died during the period 1969 through 1978 and for whom the underlying cause of death was coded as uterine cancer. To evaluate the recorded cause of death Alberta Cancer Registry records, which existed for 97% of the women, were examined. Calculations from the revised information showed an increase in the mortality of cancer of the corpus uteri and a decrease in the mortality of cancer of the cervix uteri over the 10-year period, but neither was statistically significant. During the same period in Alberta the incidence of cancer of the corpus uteri increased significantly and the incidence of cancer of the cervix uteri decreased significantly.

Adult↗
PubMed1977

Breast cancer and fertility trends in Canada.

The age-standardized breast cancer mortality rate for Canadian females increased only slightly during the period 1941-1971. In contrast, the age-standardized breast cancer incidence rate for Saskatchewan females more than doubled during the same period. In the interval 1954-1973 there were significant increases in the age-specific mortality rates for females 50-64 years old and in the age-specific incidence rates for five of the six age groups in the 45 to 74 year range. Breast cancer mortality rates during 1970-1972 varied considerably by province. Age-specific rates in the 30-69 year range were significantly and negatively correlated with the proportions by province of married women first married at age 15-19. In Canada and Saskatchewan, respectively, the age-specific breast cancer mortality and incidence rates for females 40-59 years old were significantly and negatively correlated with cohort fertility rates at age 20-24. These data support the hypothesis that early pregnancy protects against breast cancer. The sharp decline in fertility rates since 1960 may result in an increased incidence of breast cancer in the future.

Adolescent↗