The advent of nuclear cardiology has resulted in a veritable explosion of new techniques for evaluating coronary artery disease. Most of these new techniques for detecting myocardial performance, myocardial perfusion patterns, shunt detection, and infarct detection can be done in sequential noninvasive fashion so that patient may be selected earlier in their disease when the benefits of surgical and medical therapy may be restorative rather than reparative. It is hoped this new medical technology will satisfy the desire of Mackenzie for "comparative evaluation of medical remedies and different modes of treatment of disease by the lynx-eyed scrutiny of dispassionate analysis."

Coronary Disease↗

PubMedDate not supplied

A new constant infusion radioisotopic technique for the noninvasive determination of cardiac output.

A constant infusion radioisotopic method for the noninvasive determination of cardiac output is introduced and validated in a series of 22 patients by comparison with simultaneous dye dilution or Fick measurements. The new bedside radioisotopic technique utilizes peripheral venous infusion of indium-113m, detection by a single external probe, and analysis of the time-concentration curve by a specially designed, multivariate computer model. The technique is entirely atraumatic, requiring neither injection into the central circulation nor intra-arterial cannulation. The correlation coefficient was 0.72 (p less than 0.001) between the radioisotopic and standard methods for cardiac output determinations. In addition, results in five patients with valvular regurgitation or intracardiac shunts support the validity of the constant infusion radioisotopic technique in these clinical settings in which the standard dye dilution methods for determining cardiac output are invalid. The techniques is applicable in a variety of clinical conditions in which the invasive techniques for cardiac output measurement are either impractical or not available.

Adult↗

PubMedDate not supplied

Effects of medical and surgical therapy on myocardial perfusion in coronary disease evaluated by cardiac scintigraphy.

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Adrenergic beta-Antagonists↗