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PubMedDate not supplied

Tissue expanded free flaps.

Over the last few years there have been various reports of the use of tissue expanders as an adjunct to microvascular free transfer of tissue. This study looks at the effect of expanding the actual flap prior to transfer. Two case reports are given and it is proposed that expanded free flaps are large and thin. They have a capsule which enables them to be safely sutured under tension. They are "delayed" by the expansion process and the donor deformity is minimal. It is suggested that tissue expansion is a useful technique prior to free flap transfer for the reconstruction of large defects.

Adolescent↗

PubMedDate not supplied

Two case reports of vinorelbine extravasation: management and review of the literature.

Vinorelbine tartrate (Navelbine, Burroughs Wellcome Company, Research Triangle Park, NC, USA) is a semisynthetic vinca alkaloid approved in many countries for the first-line treatment of patients with advanced non-small-cell lung cancer. It is also used in the treatment of advanced breast and ovarian cancers and lymphoma. Like other vinca alkaloids, Navelbine can cause skin necrosis as a consequence of inadvertent extravasation in surrounding tissues during intravenous administration. In such cases, early treatment is strongly advocated. There is no documented case of vinorelbine extravasation in the literature. The authors herein report two cases successfully treated with hyaluronidase injections plus saline flushout under local anesthesia.

Anesthesia, Local↗