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Community Health Nursing↗
Biomedical subjects
D Swiderska
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Participation of prostaglandins E2 and F2 alpha in the action of fibrinopeptides A and B on the central dopaminergic system.
The participation of prostaglandins (PGs) E2 and F2 alpha administered icv in the action of fibrinopeptides A and B (FAB) on the central dopamine neurons was investigated. PGE2 and PGF2 alpha (0.5 microgram) attenuated the intensity of apomorphine (APO)-induced stereotypy and completely abolished the stimulatory action of FAB. PGE2 given together with FAB attenuated, while PGF2 alpha did not affect the amphetamine-induced stereotypy and haloperidol-induced catalepsy. The investigated PGs did not affect or normalized the level of dopamine depressed by peptides in some parts of the brain. The results indicate that PGE2 alpha and PGF2 alpha do not participate in the mechanism of the central action of FAB.
Amphetamine↗
Action of fibrinopeptides A and B on the central dopaminergic system of rats pretreated with indomethacin.
Fibrinopeptides A and B (FAB) stimulate central dopamine neurons. Inhibition of prostaglandin synthesis by administration of indomethacin potentiated the stimulatory action of FAB on apomorphine stereotypy, while induced inhibitory action of FAB on amphetamine stereotypy. Results of studies on the level and turnover of dopamine do not explain the changes in the stereotyped behavior. The data suggest that prostaglandins may to some extent participate in the mechanism of the central action of FAB.
Amphetamine↗