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Biomedical subjects

D Sullivan

Publications and source records attributed to D Sullivan.

At least 127 records · Page 7Linked to original sources

Accuracy of radionuclide imaging in distinguishing renal masses from normal variants.

To determine the accuracy of scintigraphy in distinguishing true renal masses from normal variants, 40 patients with excretory urographic findings indicating a possible, but not definite, mass lesion were studied. Scintigraphy correctly identified 17 true masses and 17 normal variants. Four false positive and two false negative results were obtained.

Abscess↗

The organization of a nuclear DNA sequence from a higher plant: molecular cloning and characterization of soybean ribosomal DNA.

The recombinant DNA vector, lambda Charon 4A, was used to construct a library of DNA sequences from the genomic DNA of soybean (Glycine max). To define the organization of ribosomal DNA (rDNA) in the soybean genome, clones containing sequences complementary to both 17S and 25S rRNA have been isolated from this library and used in conjunction with Southern blot hybridization. The rRNA genes are tandemly reiterated with a relatively small unit repeat length of 7.8 kb. There is no heterogeneity in the length of the rDNA repeat units although they display limited differences in either base sequence or pattern of methylation. The cloned rDNA sequences are shown to comprise the entire repeat unit and have been used to obtain a detailed restriction map as well as an approximate transcription map of soybean rRNA genes. The cloning of rDNA from soybean suggests that recombinant DNA techniques can be successfully applied to the genomic DNA of higher plants despite the high degree of methylation exhibited by plant DNA.

Bacteriophage lambda↗

An evaluation of the 24-hour RAIU test performed with an Anger camera and a pinhole collimator.

RAIU measurements obtained with a conventional thyroid uptake probe have been compared with those obtained with an Anger camera and a pinhole collimator. Although the field distribution for the pinhole collimator deviates markedly from the IAEA recommendations, the group data from the comparative measurements in this series were identical, with a confidence level of 99%. However, in several cases the data from differing measurement regimes for individuals varied markedly.

Humans↗

The treatment of perceptual disturbances in schizophrenia with naloxone hydrochloride.

The authors treated 12 schizophrenic patients who had overt hallucinatory symptoms with intravenously administered naloxone hydrochloride, a narcotic antagonist purported to have antihallucinatory properties. They found no evidence of the effectiveness of naloxone in preventing hallucinations over that of placebo when administered in a randomized, double-blind fashion.

Adult↗

Gray scale ultrasound and isotope scanning: complementary techniques for imaging the liver.

Technical advances in gray scale ultrasound have led to better signal-to-noise ratios and improved resolution. A display of the texture of the liver is now possible, making ultrasound an important complementary technique to radioisotope scanning. In the positive radioisotope scan, ultrasound permits differentiation of isotopically cold areas into neoplasms, benign cysts, and abscesses. In addition, when the radioisotope scan is equivocal, ultrasound is invaluable in differentiating normal variants from disease states. Dilated intrahepatic ducts can also be identified. Examples of the use of ultrasound in defining radioisotope abnormalities are presented.

Adult↗