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Biomedical subjects

D Stolke

Publications and source records attributed to D Stolke.

123 records · Page 7Linked to original sources
PubMed1981

[A method of measuring centrally determined disturbances of muscle tone (author's transl)].

A technique is described (myotonography) for recording the centrally determined disturbances of muscle tone, whereby the mechanical and electro-myographic changes in the affected muscle groups are accessible to objective and quantitative study. The efficacity and reliability of the method are given and the clinically distinguishable forms of central disturbances of tonus are shown in typical tracings. These are of particular value for assessing the progress of an illness and the results of treatment. In addition it facilitates the interpretation of the patho-physiological processes. The apparatus is so constructed that in the same way as in a clinical examination, a passive extension and flexion of the elbow joint is reproduced over a range of about 100 degrees. In this way it is possible to record the stretch resistance of the extremities as well as the superficial electromyogram of the flexors and extensors.

Adolescent↗
PubMed1980

Barbiturate treatment and membrane stability of subcellular organelles.

The experimentally well established protective effect of barbiturate anaesthesia in cerebral ischaemia and increased intracranial pressure (ICP) has been assumed to be primarily a consequence of the reduction in cerebral metabolic rate. We present the results of studies of the influence of pentobarbitone on the stability of lysosomal membranes in the grey and white matter of the cat brain. To indicate the grade of stability of share of free activity of the lysosomal enzyme beta-glucuronidase was assayed. Animals pretreated by pentobarbitone showed a significant decrease of the share of free activity in the white matter. This indicates an increase in lysosomal membrane stability. Increased lysosomal membrane stability is regarded as a protective effect of pentobarbitone against brain ischaemia and severe head injury.

Animals↗
PubMed1980

[The effect of ketamine on the lysosomal enzymes of the brain tissue (author's transl)].

The action of ketamine on the lysosomal of the white and gray matter was studied by estimating the ratio: free acid hydrolase beta-glucuronidase/total activity. Administration of ketamine was followed within 24 hours by stabilization of the lysosomal membrane of the white matter. Despite this protective effect on the subcellular structures of the white matter ketamine cannot, because of its excitometabolic action, be recommended as an anaesthetic agent with brain-protecting properties.

Anesthesia↗
PubMed1979

The protective effect of steroid treatment on lysosomal enzymes after cold lesion of the cat brain.

The effect of posttraumatic steroid treatment (6-methylprednisolone) on the stability of lysosomal membranes in the cat brain is studied. The share of free activity of the lysosomal enzymes beta-glucuronidase and N-acetylhexosaminidase indicates the grade of membrane stability. The results demonstrate an increased stability of lysosomal membranes in grey as well as in white matter after posttraumatic steroid treatment. This regarded as an important aspect of the protective effects of steroid treatment in posttraumatic brain edema.

Animals↗
PubMedDate not supplied

[Lymphangiomum cysticum congenitum of the left half of the face in a newborn infant].

In a mature dystrophic newborn a huge tumor of the face was evident. The left eye could not be seen, the left choana was obstructed, the left angle of the mouth was pushed caudally. Sonographically cystic and solid areas could be found. The cranial computer tomography showed normal intracerebral structures but some evidence of infiltration into the frontal brain. The left ocula was widened and the left eye was found within the tumor mass. Angiographically an abnormal vascularisation of the tumor could not be seen. In spite of corticoid therapy a rapid growth led to life-threatening obstruction of the airways. At the age of 6 weeks the tumor was totally extirpated. A small piece of dura mater was replaced by periost. The wound could not be closed. Histologically the diagnosis of lymphangioma cysticum congenitum was made and increased growth tendency were found. Four weeks postoperatively the baby was discharged. Several cosmetic operations with unpredictable results will be necessary. A close psychologic guidance is recommended. Localisation, size, and life-threatening growth of a benign lymphangiomum are very uncommon.

Facial Neoplasms↗
PubMedDate not supplied

[Carpal tunnel syndrome following arteriovenous forearm shunt in chronic dialysis patients--a review of 24 surgically treated patients].

In a period from January 1981 to September 1985 271 patients underwent surgery because of a carpal tunnel syndrome (CTS). In 24 patients (30 operated hands) with permanent kidney failure the CTS followed an arterio-venous shunt procedure in the forearm. Although there is a considerable variability concerning the interval between dialysis and onset of symptoms of median nerve entrapment CTS in patients with chronic hemodialysis is considered to be a late complication. In contrast in patients with idiopathic CTS a considerable time-lag has been noted between onset of symptoms and operative treatment which may be due either to diagnostic difficulties and/or delayed referral. The clinical picture presents with typical signs of a median nerve compression, known as brachialgia paresthetica nocturna. Operative treatment which consists of surgical division of the transverse ligament in local anaesthesia without interfascicular neurolysis is followed by immediate and usually longlasting pain relief. The possible etiology of CTS in patients with chronic hemodialysis which seems to be due to multiple factors is discussed.

Adult↗
PubMedDate not supplied

[Clinical aspects, surgical treatment and prognosis of lumbar intervertebral disk displacement in childhood].

This paper reports on 11 girls and 3 boys aged from 12 to 16 who, having suffered prolapses of lumbar discs, underwent surgery and were followed up between 18 and 87 months postoperatively. These 14 patients represent 0.25% of those who have undergone disc surgery in the authors' clinic over the last 11 years. Clinical peculiarities are pointed out and, in the light of the positive results (13 patients completely free of complaints) the prognosis is deemed to be very favourable; surgical treatment is therefore recommended of conservative therapy fails.

Adolescent↗
PubMedDate not supplied

[Spinal dysraphia and disordered ascension of the spinal cord in adults].

Spinal dysraphism and tethered cord syndrome which frequently present with clinical symptoms during infancy, childhood and adolescence are rarely encountered in adults. In this retrospective study covering a period of 15 years were report of 12 patients aged from 22 to 71 years with delayed symptoms from the tethered spinal cord. The clinical signs and symptoms which consisted of progressing neurological, urological and orthopedic malfunctions as well as the aspects of current neuroradiological diagnosis including myelography, CT-scan and MRI are presented. The possible pathophysiological mechanism responsible for the delayed onset of the sequelae of the tethered cord are discussed. It is concluded that neurosurgical therapy should be performed in cases of progressing clinical deterioration and the results of surgery in our patient group are presented.

Adult↗
PubMedDate not supplied

Aneurysmal rupture during embolization with Guglielmi detachable coils: causes, management, and outcome.

BACKGROUND AND PURPOSE: Aneurysmal rupture during endovascular treatment is one of the most feared complications of endovascular aneurysm therapy. The purpose of this study was to determine the frequency, causes, management, and outcome of aneurysmal rupture that occurred during treatment with Guglielmi detachable coils (GDCs) in an unselected series of patients with ruptured cerebral aneurysms. METHODS: Between July 1997 and December 2000, we treated 164 acutely ruptured cerebral aneurysms with GDCs. All charts were reviewed, and patients with aneurysmal rupture occurring during embolization were identified. RESULTS: Five patients had an intraprocedural aneurysmal rupture. In one patient, rupture was due to guidewire perforation of the wall. In two patients, the microcatheter itself perforated the aneurysm. In another two patients, rupture occurred during placement of the first coil. Endovascular packing was continued in all patients. One patient died as a result of the aneurysmal rupture. No negative long-term effects were observed in the remaining four patients. In summary, we observed intraprocedural aneurysmal rupture in 3% of our patients, with a mortality rate of 20% and no long-term morbidity. CONCLUSION: Aneurysmal rupture during endovascular treatment with GDCs is a rare event; clinical severity may be variable. Embolization of the aneurysm can be continued in most cases, and most patients with treatment-related subarachnoid hemorrhage survive without serious sequelae.

Adult↗