Search PubMed⌕ Search

Biomedical subjects

D St Clair

Publications and source records attributed to D St Clair.

80 records · Page 5Linked to original sources
PubMed1987

Auditory P300 in borderline personality disorder and schizophrenia.

Using three sets of clinical criteria to define borderline personality disorder (BPD), P300 (P3) and other long-latency auditory event-related electroencephalographic potentials were measured in 22 subjects with BPD, 32 subjects with other personality disorders, 29 schizophrenics, 22 depressives, and 74 volunteer controls. The patients with BPD were found to differ from patients with nonborderline personality disorders, having a longer P3 latency and smaller P3 amplitude. Long-latency event-related potentials were similar in the BPD and schizophrenic groups and did not differentiate patients with BPD with a concurrent diagnosis of schizotypal personality disorder from those without schizotypal personality disorder. The P3 latency and amplitude changes distinguished the BPD and schizophrenic groups from normal controls, those with major depressive disorder, and those with nonborderline personality disorders. These findings suggest that though some patients with BPD may have depressive symptomatology, they share with schizophrenics a dysfunction of auditory neurointegration.

Adolescent↗
PubMed1983

Hypertension, multi-infarct dementia and Alzheimer's disease.

Retrospective review of 89 patients with pre-senile dementia followed by necropsy indicated significant differences between sub types of dementia. Patients with multi-infarct dementia (MID, 27 subjects) more often had cardiovascular abnormalities than patients with Alzheimer's disease (46 subjects). No patients with MID alone had a systolic blood pressure below 140 mm Hg, whereas 23 of 46 Alzheimer subjects and three of 16 patients with mixed features had such a systolic pressure.

Aged↗
PubMedDate not supplied

Distribution of apolipoprotein E allele frequencies of the Han Chinese in an iodine-deficient mountainous area.

BACKGROUND: Iodine deficiency is common in the Qinba mountainous area and fetal iodine deficiency disorder (FIDD) is endemic. Our previous study demonstrated that apolipoprotein E (ApoE) was a genetic risk factor for FIDD in the local area. AIM: In order to achieve a better understanding of the aetiology of iodine deficiency-based mental retardation in the Qinba mountainous area, we conducted further studies of ApoE allele frequencies obtained from the local population. SUBJECTS AND METHODS: A total of 818 samples from four counties in the iodine-deficient area were recruited for the study of the ApoE genotype and allele frequencies using the PCR-RFLP method, and were subsequently confirmed by sequencing. RESULTS: The frequencies of epsilon2, epsilon3 and epsilon4 alleles of Han Chinese in Qinba were 9.67%, 81.30% and 9.03%, respectively. Furthermore, no significant differences in the distribution of ApoE (either genotype or allele frequencies) between any two subgroups divided according to location, sex and age (p > 0.05) were found. Surprisingly, however, we found a significant difference in the genotype and allele frequencies between Qinba and Shanghai (genotype: chi2 = 14.91, p = 0.0096; allele: chi2 = 15.07, p = 0.0009). CONCLUSION: The currently documented allele frequencies of ApoE in the Han Chinese population living in the open areas of China do not represent the distribution in the isolated Qinba mountainous area. The higher level of epsilon2 and epsilon4 allele frequencies in the Han Chinese living in the isolated Qinba area arise by chance or may result from genetic adaptation to an environment characterized by malnutrition and iodine deficiency, which may also contribute to the high incidence of mental retardation in these regions.

Adolescent↗
PubMedDate not supplied

Beyond prenatal care: a comprehensive vision of reproductive health.

The United States has lagged behind other developed nations with respect to infant and maternal mortality. In the past decade, the disparities between races and socioeconomic groups has actually widened. In response, local initiatives have sought to decrease infant mortality by enrolling women into prenatal care programs. These programs have focused solely on pregnancy, despite evidence that access to family planning, abortion, and gynecologic care is necessary to reduce both infant and maternal mortality. These prenatal care initiatives thus miss the opportunity to have an impact on some of the major public health issues facing women.

Female↗