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Biomedical subjects

D Soares

Publications and source records attributed to D Soares.

35 records · Page 2Linked to original sources
PubMed1997

IgM anti-phenolic glycolipid-I antibody measurements from skin-smear sites: correlation with venous antibody levels and the bacterial index.

Measurements of anti-phenolic glycolipid-I antibodies were made in 200 matched samples of capillary blood from the skin-smear site, venous blood collected on filter paper, and sera. A close correlation among the three samples was observed and a weaker correlation among the antibody levels and the average and skin-smear bacterial index. Capillary blood from the skin-smear site had a consistently higher level of antibodies in each sample than did the sera. The collection of capillary blood from skin-smear sites is a convenient and economical method of obtaining samples for serology and for measuring local antibody levels, and it may be more sensitive than measurements of antibodies in sera.

Adolescent↗
PubMed1996

Squamous cell carcinoma of the foot arising in chronic ulcers in leprosy patients.

Squamous cell carcinoma (SCC) of the foot is a rare sequelae of chronic ulceration secondary to leprosy neuropathy. Most of the tumours are relatively slow growing and tend to metastasize late. Survival after local excision is generally good. In this series of 17 patients so far there have been 3 deaths attributable to SCC, all of whom presented with locally advanced tumours and lymph node metastasis.

Adult↗
PubMed1996

Tibialis posterior transfer for the correction of foot drop in leprosy. Long-term outcome.

A comparison was made of the results produced by the circumtibial and interosseous routes of transfer of tibialis posterior for the correction of foot drop due to leprosy neuritis. The findings in 69 feet, of which 63 also had elongation of tendo Achillis, showed that the interosseous route gave a much lower incidence of recurrent inversion deformity of the foot. The results, in terms of improvement in gait and prevention of trophic changes, were satisfactory.

Achilles Tendon↗
PubMed1995

Tibialis posterior transfer in the correction of footdrop due to leprosy.

In the correction of footdrop due to leprosy neuritis the tibialis posterior muscle is re-routed and used to provide dorsiflexion of the foot. This study of tibialis posterior transfer was carried out to compare the results of the circumtibial and interosseous routes. There is no significant difference in the range of motion between either route through the range of the interosseous route is more functional (better dorsiflexion). The interosseous route is preferable as this results in a significantly lower incidence of recurrent inversion deformity of the foot at long-term follow-up when compared with the circumtibial route.

Adolescent↗
PubMed1995

Hand wounds in leprosy patients.

This study assessed the causes, duration and site of hand wounds seen among patients in order to try and improve the delivery of self-care teaching to patients with anaesthetic hands. Seventy-seven patients with 102 affected hand surfaces were assessed. The commonest cause was a burn from a tea glass. The average duration of the wound was 2 weeks. Most patients had a single current wound and 62% of wounds were on the palmar surface.

Female↗
PubMed1994

Mass survey of leprosy in Lalitpur district, Nepal.

An intense mass survey of leprosy in Lalitpur District, Nepal, was carried for the period 1986 to 1990. This was the first such large scale survey in Nepal; 85% of the total population was examined. The 5-year case detection rate was 13 per 10,000; the 5-year child detection rate was 4 per 10,000. By the end of the survey the prevalence rate was 6.8 per 10,000; at the end of 1992 this had dropped to 2.2 per 10,000. In 1989, after a 3-year interval, a re-survey was done in three village development committees (VDCs) and 4 new cases were detected, bringing the 3-year case detection rate to 3.3 per 10,000; 36% of the old cases, 20% of the new adult cases, and 3% of the new child cases were classified as multibacillary. Overall, 62.7% of the patients had no disability, 18.8% had disability grade 1, and 12.7% had disability grade 2 while for 5.8% the data were incomplete. By the end of the survey 91% of the patients needing medical treatment were on multidrug therapy (MDT). At present this has increased to 100%. The regularity rate was 86%; at the end of 1992 this had increased to 96%. The cost for detecting one new patient was US$298. Because of the high cost, it is recommended that intense mass surveys not be performed when the estimated prevalence rate is less than 10 per 10,000 inhabitants. From the data collected conclusions were drawn and recommendations were formulated for developing new strategies for the National Leprosy Control Programme of the Government of Nepal.

Adolescent↗
PubMed1993

Neuritis of the lateral femoral cutaneous nerve in leprosy.

Neuritis of the lateral femoral cutaneous nerve (meralgia paresthetica) is observed more frequently in leprosy than in nonleprosy patients, and its symptoms can easily be confused with those suggesting, e.g., ischialgia. The diagnosis can be confirmed by a diagnostic block with a local anesthetic solution. Analgesics, antiinflammatory drugs, bed rest and, in severe cases, therapeutic blocks were successfully applied in the treatment of the neuritis, and no surgical intervention was needed. Three leprosy patients with severe meralgia paresthetica are presented.

Adult↗
PubMed1990

Terminal deletion 6p23: a case report.

We report on a girl with cleft lip and cleft palate, antimongoloid slant of the palpebral fissures, umbilical hernia, skeletal anomalies, partial syndactyly, hypertonia with increased deep tendon reflexes, psychomotor and growth retardation, and other congenital anomalies. Cytogenetic studies demonstrated a 46,XX,del(6)(qter----p23:) chromosome constitution.

Abnormalities, Multiple↗
PubMedDate not supplied

Cartilage-hair hypoplasia syndrome: immunological evaluation of two cases.

PURPOSE: Immunological evaluation of patients with cartilage-hair hypoplasia. TYPE: Prospective and retrospective studies. PLACE: Division of Allergy, Clinical Immunology and Rheumatology-Dept. of Pediatrics-"Escola Paulista de Medicina". PATIENTS: Two children with cartilage-hair hypoplasia syndrome. METHODS: Clinical and immunological evaluation. Humoral immunity (immunoglobulin levels, poliovirus antibodies, etc.) and T cell immunity (in vitro cultured lymphocytes stimulated with PHA, Con A and PWN, total T cell and subset determination) were studied. RESULTS: Cellular immunodeficiency and hypogammaglobulinemia were observed in one patient and normal values in the other. CONCLUSIONS: Immunological evaluation (cellular and humoral) should be performed in all patients with cartilage-hair hypoplasia.

Antibody Formation↗