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D Sirbat

Publications and source records attributed to D Sirbat.

At least 37 records · Page 2Linked to original sources
PubMed1985

[Arterial supply to the anterior segment of the eye. Radioanatomical study of a series of 25 human eyes].

We studied the arterial vascularization of the anterior segment of 25 cadaver eyes. Arteries had been opacified by an injection of an aqueous suspension of barium. Our study has focused on the anterior ciliary arteries (ACA), emerging from the four rectus muscles. Among the numerous individual variations, we have noticed the following predominant aspects: for the external rectus muscle, the ACA is usually unique and thin, located in the superior or inferior third of the muscle. For the others rectus muscles, the ACA are rather big and frequently observed in pairs. They tend to be found on each lateral side of the muscle. By and large, the vertical ACA look bigger and more numerous than the horizontal ACA. The number, the size and the position of the long posterior ciliary arteries are quite uniform. The major arterial circle of the iris seems to be discontinuous, and is more and less made of arterial anastomoses. This study enabled us to reconsider the usual anatomical description of arterial supply of the anterior segment. The vascularization by the ACA, especially at the level of the inferior and superior rectus muscle, has to be known in order to avoid an anterior segment ischemia following strabismus surgery.

Adult↗
PubMed1984

IgA nephropathy: dimeric IgA-secreting cells are present in episcleral infiltrate.

Recent publications have reported a frequent association between IgA nephropathy and episcleritis. In this article, the authors report on the immunohistologic study of an episcleral biopsy obtained in a female patient with Berger's disease and frequent episodes of episcleritis. Numerous dimeric-IgA-secreting cells were demonstrated in the episcleral inflammatory infiltrate. It also should be mentioned that microhematuria often occurred within a few days after the beginning of episcleritis in this patient. These results suggest the participation of ocular mucosal immunity in some cases of IgA nephropathy.

Adult↗
PubMed1983

[A new etiology of episcleritis: nephropathies with IgA and/or isolated C3 deposits].

Scleritis is a condition of the eye often associated with systemic diseases, allergy and infections. Nomoto et al. have reported the frequency of episcleritis in patients with IgA nephropathy (Berger's disease), a primary glomerulonephritis initially described by Berger in 1968. It is characterized by mesangial deposits of IgA, and is considered one of the most frequent nephritides in France. We report our study of the association of scleritis with glomerulonephritis (GN). Fifty-three GN patients were examined for the presence of scleritis. The exact type of nephropathy in each patient was determined by a renal biopsy and immunofluorescence studies. Episcleritis was found in 10 GN patients: in 5 out of 27 Berger's disease, 3 out of 4 patients with isolated mesangial C3 deposits, 1 out of 2 patients with membraneous GN, and 1 out of 5 patients with membranoproliferative GN. The finding of episcleritis in 18% of patients with IgA nephropathy is very similar to the results reported by Nomoto et al. (15%). As no other cause of episcleritis was found in these positive patients, the ocular lesion may be considered to be related to their GN. Episcleritis patient had no abnormal levels of serum IgA, but circulating immune complexes activating the alternate pathway of the complement system were present in most of them. In one female patient with Berger's disease and frequent episodes of episcleritis, an episcleral biopsy was obtained for immunohistological studies. Large numbers of dimeric IgA secreting plasma cells were observed in this tissue. These results suggest the involvement of ocular surface immunity in some cases of IgA nephropathy. It might therefore be useful to investigate the renal function of patients presenting recurrent episodes of episcleritis.

Complement C3↗
PubMed1983

[Serous macular detachment of the neuro-epithelium and flumequine].

Flumequine (1 200 mg/day) was prescribed as treatment for infection of the urinary tract to three patients with chronic renal failure, who reported positive scotoma three days later. Ophthalmologic examination evinced bilateral symmetrical macular bullae. A characteristic yellow papule was present at foveal level. In all three cases, visual acuity was impaired (down to 4/10), without any angiographic alteration. Foveolas showed a moderate persistent hyperfluorescence. All patients recovered a normal visual acuity, within two days after treatment cessation, and bullae disappeared without sequelae within 5 days. The chronology and kinetics of clinical manifestations were clearly and reproducibly correlated with flumequine therapy in all patients, and suggest that this drug may be considered responsible for the ocular symptom reported. Chronic renal failure (creatinine clearance lower than 25 ml/mn) most certainly favoured the appearance of visual troubles, but other factors may possibly play a similar role: hepatic failure, individual hypersensitivity... Quinolones used as urinary antiseptics (nalidixic acid, oxolinic acid, pipemidic acid...), and other flumequine analogues may possibly be involved in such side-effects. This was reported by Bouissou et al. in an experimental model with nalidixic acid, where transient bullae appeared on young animals' articular cartilage. Such lesions are related to focal alterations of the C2 intermediary layer of cartilage, with marked edema of the interstitial material. The volume of synovial fluid increases concomitantly. These alterations suggest a direct cytotoxic effect at the intercellular level of target organs, a mechanism possibly also occurring in the retina.

Adult↗
PubMed1980

[Arterial vascularization of the rectus medialis and lateralis oculi muscles (author's transl)].

The arterial vascularization of the rectus medialis and lateralis oculi muscles was studied in cadaver following the injection of a stable suspension of radiopaque barium sulfate in the internal carotid artery. This straightforward and reliable original technic allows a good visualization of the arterial branches assigned to the muscles at the time of the orbital dissection. The arterial pedicles intake points inside the muscles are optionally placed on the level with the posterior two-third and generally they are more posterior for the lateral rectus than the medial rectus. We have then removed 30 rectus medialis muscles and 30 rectus lateralis muscles for the radioanatomic study of their intrinsic vascularization. Histological tests proved that an impregnation of 10 microns was up to the capillaries and that the vascular structures were respected. We have been able to characterize main and secondary intrinsic arterial pedicles which constitute a very rich anastomotic network. The main pedicles have a central or lateral topography and their distribution is independent of the way the ophthalmic artery crosses the optic nerve.

Aged↗
PubMedDate not supplied

Comparison of two fixed beta-blocker-pilocarpine combinations. The Carteolol-Pilocarpine Study Group.

PURPOSE: To compare the efficacy and safety of a newly developed ophthalmic solution containing carteolol 2% and pilocarpine (2% (CBS341A) with a timolol 0.5% and pilocarpine 2% fixed combination. PATIENTS AND METHODS: A randomized, double-masked, multicenter study was conducted in 209 patients with primary open-angle glaucoma or ocular hypertension, whose intraocular pressure (IOP) was higher than 21 mm Hg on bet-blocker twice a day alone. The test medications were administered twice daily for 4 months. IOP was measured at 9 and 11 a.m. at the beginning of the study (with beta-blocker alone) and after one and four months of treatment. Adverse effects were recorded. RESULTS: Both combinations caused a similar, statistically significant decrease in IOP. At four months, in the CBS341A group a 2.4 mm Hg (9%) reduction in IOP was achieved at 9 a.m. and 4.1 mm Hg (17.3%) at 11 a.m. compared with respectively 3 mm Hg (11%) and 4.5 mm Hg (19.5%) in the timolol-pilocarpine group. No statistical difference was observed between the two groups in safety and efficacy. CONCLUSIONS: The carteolol-pilocarpine combination appears as safe and as effective as the timolol-pilocarpine combination in the medical treatment of primary open-angle glaucoma or ocular hypertension.

Adrenergic beta-Antagonists↗
PubMedDate not supplied

[Oculomotor disorders and enlargement of the extraocular muscles].

Aetiologic conditions for enlargement of extra ocular muscles are graves' orbitopathy, acute or subacute myositis as a subgroup of inflammatory orbital pseudotumor, and sometimes lymphoid or metastatic tumor. The distinction of these aetiologies can be made on clinical versus CT Scan or IRM grounds with two different patterns of oculomotor disfunction. Restrictive extensibility, which found expression in the antagonist field, is typical of grave's myopathy, sequelae of subacute myositis or acute myositis of the superior oblique. Deficiency of the enlarged muscle's contractibility is typical of a recent and transient myositis involving a rectus muscle or of a rare tumor of an extraocular muscle.

Diagnosis, Differential↗