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Biomedical subjects

D Singh

Publications and source records attributed to D Singh.

At least 289 records · Page 16Linked to original sources
PubMed1984

Anterior radial keratotomy experience in 600 cases of myopia.

Surgical results of anterior radial keratotomy in 1,200 eyes are presented. Of the eyes, 55% had an unaided visual acuity of 6/9 or better six months after surgery. An average of 1.90 D of myopia was corrected in these cases. It takes six weeks for the refraction to stabilize and to know the final success of surgery. There was no statistically significant influence of age or sex or preoperative refractive error on the amount of surgically induced change in refraction. The extent of myopia corrected is directly proportional to the change induced in the radius of curvature. The operative and postoperative complications were minimal and did not endanger vision.

Adolescent↗
PubMed1983

Glucose: a role as a free radical scavenger in biological systems.

Recent observations indicate that OH . may be important in the microbicidal capacity of phagocytic cells, in prostaglandin metabolism, and as a mediator of inflammation. Although glucose is a weak hydroxyl scavenger, it occurs in high concentrations in biological systems. We therefore studied the capacity of glucose to scavenge OH . in biological systems known to generate this reactive oxygen species. Our experiments used a specific assay for the detection of OH .. We measured 14CO2 released during the oxidation of 14C-benzoic acid. We have previously demonstrated that benzoic acid is oxidized as a consequence of OH . in the following systems: the enzyme system xanthine-xanthine oxidase, zymosan-stimulated granulocytes, and arachidonic acid-stimulated platelets as a consequence of the lipoxygenase pathway. In all three systems the oxidation of benzoic acid was inversely proportional to the concentration of glucose in the assays. Also, platelets incubated with arachidonic acid and a high concentration of glucose increased HETE production, an effect predicted by the capacity of glucose to act as an OH . scavenger. Our results indicate that glucose acts as a scavenger of OH . in physiological concentrations and therefore may serve an antioxidant role in biological systems. In addition, the capacity of glucose to act as an OH . scavenger may explain some of the defects seen in patients with diabetes mellitus.

Benzoates↗