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Biomedical subjects

D Sidiropoulos

Publications and source records attributed to D Sidiropoulos.

53 records · Page 3Linked to original sources
PubMed1976

[Statistic evaluation of anamnestic and clinical findings in a premature labor collective of 245 cases].

245 cases of premature birth were compared from the point of view of frequency of aetiologically significant factors with 200 cases of normal birth. The perinatal progress of these premature and normal births was also followed up. It was possible to obtain statistical confirmation of the connection between prematurity and frequent occurrence of some of these parameters. Prominent amongst these are previous abortions and premature births, cervical insufficiency and malformation of the uterus, multiple pregnancies and anomalous foetal position, also placental insufficiency. Increased mortality and morbidity--including perinatal complications--were recorded at the same time. Knowledge of predisposing factors will in many cases make it possible to recognize in good time when pregnancies may be at risk and give adequate supervision and treatment where appropriate.

Abortion, Habitual↗
PubMedDate not supplied

Outcome of 100 randomly positioned children of very low birthweight at 2 years.

Prematurely born children often show a tendency to adopt extensor motor patterns during the first years of life. These children and especially those children of very low birthweight are considered to be at high risk for abnormal development. Positioning in an ordinary manner or in a more flexed position imposed at random during the neonatal period until discharge from hospital did not have a statistically significant influence on the development of these children at 24 months after term. Analysis of the optimality score of the 100 randomly selected children, born consecutively at the University Women's Hospital, Bern, showed a significant influence of prenatal optimality and congenital malformations on their later outcome.

Child Development↗
PubMedDate not supplied

[Prevention of hyaline membrane disease by intraamniotic administration of thyroxine].

The best management of respiratory distress syndrome (RDS) is prevention. Prenatal administration of Cortico-steroids has been proved to be a valuable way for accelerating fetal lung maturation. In case of high risk pregnancy, however, where acceleration of lung maturation is most needed, there may be a relative contraindication for using steroids. According to the theory that the increase in the phospholipid component of surfactant may be mediated by intra-amniotic thyroxin administration, its use for accelerating human fetal lung maturation has been tested. Seven samples of amniotic fluid were obtained in order to determine the lung maturity in seven pathological pregnancies (pre-eclamptic toxemia, diabetes, infection, hypertension, placental insufficiency) prior to elective caesarean section. Since thyroxin does not cross the placenta, it has to be injected directly into the amniotic sac. 20 ml of clear fluid were obtained by amniocentesis prior to each injection of 250 micrograms of Levothyroxin through the same needle. Each of the infants was delivered before 34 weeks. Birth weights of the premature infants were between 1220-1870 grams. In all cases the Lecithin/Sphingomyelin Ratio (L/S) in amniotic fluid analysis was immature. After thyroxin administration L/S Ratio was mature in pharyngeal aspirate examination after delivery in 6 cases. RDS was seen in only one infant. The interval between intraamniotic administration of T4 and delivery ranged from 72 hours to 2 weeks in 6 cases. In one case with clinical and radiological signs of RDS the injection-delivery interval was less than 48 hours: the L/S Ratio in pharyngeal aspirate was immature 2,8 (normal greater than 3).(ABSTRACT TRUNCATED AT 250 WORDS)

Amnion↗