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Biomedical subjects

D Sharma

Publications and source records attributed to D Sharma.

At least 163 records · Page 9Linked to original sources
PubMed1990

Hemiplegic migraine.

Eight patients with hemiplegic migraine are described. Majority were in their second decade and suffered two or more episodes of dense hemiplegia outlasting the headache. Complete recovery was the rule.

Adolescent↗
PubMed1989

The role of esophageal leads in the detection of exercise-induced postero-basal ischemia.

The effects of maximal hyperventilation and submaximal exercise were studied on the unipolar, esophageal electrocardiogram recorded at ventricular level in 25 'normal' persons and 15 patients having ischemic heart disease with a positive exercise stress test. In normal persons, hyperventilation decreased the amplitude of the R and T waves in 10 and 6 cases, respectively. Submaximal exercise increased the height of the P wave in 8 cases, decreased the amplitude of the R wave in 16 cases and increased the depth of the S wave in 10 cases. In patients with established ischemic heart disease, the esophageal lead could detect exercise-induced posterior ischemia in 8 cases when compared to lead V8, which could detect posterior ischemia in only 3 cases. It is inferred that the esophageal lead placed at the ventricular level is much more sensitive in detecting exercise-induced posterobasal ischemia. Lack of facilities for coronary angiographic and exercise thallium scintigraphic studies limited us from correlating this study and thereby establishing its independent usefulness.

Coronary Disease↗
PubMed1989

Kala-azar mortality in hospitalized cases in north Bihar, India.

The mortality in kala-azar was studied in 261 cases admitted in SKMCH during the years 1983-1987. 23 deaths (8.81%) were observed; 9 (39.1%) died due to complications of the disease, while 14 (60.9%) died of toxicity of Sodium Stibogluconate or Pentamidine.

Adult↗
PubMed1989

Juvenile diabetes manifesting as epilepsia partialis continua.

Epilepsia partialis continua was the chief initial complaint in a young diabetic who was found to have hyperosmolar non ketotic hyperglycaemia. Such a presentation in a juvenile diabetic is rare. Literature relevant to this interesting neurologic disturbance has been briefly reviewed.

Adult↗
PubMed1989

Poliomyelitis in vaccinated children.

Fifty-two children who had received at least 3 properly spaced doses of oral polio-vaccine and had developed acute poliomyelitis inspite of vaccination were studied clinically and serologically. This group (A) was compared with 28 children with poliomyelitis who had not received any vaccination (Group B). A much higher incidence of provocative injection and a better muscle power on presentation was seen in Group A as compared to Group B. Polio-virus type 2 was the commonest etiological agent in Group A (42.3%) whereas type I virus was most commonly seen in Group B (78.6%). A total 53.8% of cases of Group A had protective antibody titres to at least one poliovirus type in the acute phase sera, compared to only 4% from Group B. Six per cent from Group A had protective antibodies to all three virus types, disease in these cases was caused by non-polio agents. Two cases in Group A were possibly vaccine induced paralysis. Recovery, after 60 days, was much better in Group A as compared to Group B. Mortality in the two groups was comparable.

Child↗
PubMed1989

"Top of the basilar" syndrome: a clinical and CT analysis.

Fifteen patients presenting with visual, oculomotor and behavioural disturbances were diagnosed to be suffering from "top of the basilar" syndrome. Computed tomography confirmed the distribution of infarctions in the vascular territory of the rostral basilar artery. The clinical profile comprised cortical blindness and visual field defects, vertical gaze paresis, memory and behavioural disturbances and in one patient, the paramedian diencephalic syndrome.

Adult↗
PubMed1988

Heterogeneous photochemical and chloroplasts mediated activation of spinach fructose-1,6-bisphosphatase.

A heterogeneous photochemical electron relay system was constructed, mimicking the chloroplast electron transport reaction, in order to activate fructose-1,6-bisphosphatase in light. The photocatalyst acridine orange or proflavin sensitizes EDTA dependent reduction of ferredoxin. In a complete system, consisting of a dye-donor couple, ferredoxin, thioredoxin and ferredoxin-thioredoxin reductase, light activation of purified spinach fructose-1,6-bisphosphatase was observed in vitro. The ferredoxin was not essential for activation of fructose-1,6-bisphosphatase using heterogeneous photochemical system while chloroplasts mediated redox activation essentially required ferredoxin. The heterogeneous photochemical system activated fructose-1,6-bisphosphatase by about 6 fold similar to chloroplasts mediated ferredoxin dependent redox activation. These observations suggest that a thiol mediator is essential for the reductive activation of carboxylating enzymes of photosynthesis. The mechanism of activation is discussed.

Acridine Orange↗
PubMed1985

Primary squamous cell carcinoma of the thyroid gland--a case report.

Primary squamous cell carcinoma of the thyroid gland is rare. We report here a case of primary squamous cell carcinoma of the thyroid gland in a middle aged woman who had a thyroid nodule of 12 years duration with a recent rapid increase in size and associated with pressure symptoms. There was massive enlargement of the thyroid with retrosternal extension and fixity. Cervical nodes were also enlarged. The X-rays revealed calcification. A palliative thyroidectomy was done leaving the residual tumour behind. Endotracheal intubation and tracheostomy were required for respiratory distress in the postoperative period.

Carcinoma, Squamous Cell↗