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Biomedical subjects

D Seybold

Publications and source records attributed to D Seybold.

At least 19 recordsLinked to original sources
PubMed1983

The garland type of acute postinfectious glomerulonephritis: morphological characteristics and follow-up studies.

Among 44 patients with acute post-infectious GN, we found 11 cases (10 male, 1 female) displaying an immunohistologically and electron microscopically characteristic "garland pattern". Numerous sub-epithelial deposits of the "hump" type with characteristic patchiness correspond in the electron micrograph to densely packed deposits (IgG, always combined with C3, more rarely also with IgM) demonstrable immunohistologically on the peripheral loops. On the other hand, sub-endothelial, mesangial and intramembranous deposits are less prominent. Clinically, the patients have a strikingly high proteinuria. Follow-up studies have revealed that in a proportion of the patients both the clinical and the morphological findings can regress after a month long course. These are mainly younger patients. On the other hand, in another group of cases (mainly older patients) both the clinical and the morphological findings persist even after months. Within acute post-infectious GN, the "garland type" appears to form a particular group in which a large proteinuria (with or without nephrotic syndrome) and a tendency to chronicity or at least to a protracted course is present in a relatively high percentage.

Adolescent↗
PubMed1982

[Immunosuppressive therapy following kidney transplantation].

Immunosuppressive therapy is necessary after transplanting allogenous organs. Various methods of non-specific immunosuppression are discussed. It is usually achieved by combined administration of glucocorticosteroids, azathioprine and antilymphocyte globulin. Improvement may result from using cyclosporine A. Other methods such as total radiation of the lymph nodes, drainage of the thoracic duct or plasmapheresis are restricted in their application because of additional high risk and the additional effort. Complications after a kidney transplantation are often complications of the immunosuppressive therapy. Low dosage of the substances used and limitation of the dosage in the therapy of acute rejection seem to be advisable.

Adrenal Cortex Hormones↗
PubMed1981

Natural cytotoxicity of blood mononuclear cells from normal subjects and patients with Hashimoto's thyroiditis against normal thyroid cells.

Natural cytotoxicity of human blood mononuclear cells against dog thyroid cells grown in monolayer was investigated. Cytotoxicity was assessed as specific release of 51Cr from Na51CrO4 labelled thyroid cells. The effector cells were unfractionated blood mononuclear cells prepared by Hypaque-Ficoll gradient centrifugation. Killing of dog thyroid cells by peripheral blood mononuclear cells from normal subjects was demonstrated. This was time and effector: target cell ratio dependent. Killing by peripheral blood mononuclear cells from patients with Hashimoto's thyroiditis was similar to that for normal subjects although increased killing was demonstrated in 2 patients and decreased killing in 2 patients. A possible role of natural cytotoxicity against thyroid cells in thyroid autoimmunity is discussed.

Adult↗
PubMed1980

[Embolization of renal artery -- an alternative in nephrectomy in the treatment of patients with dialysis and malignant hypertension (author's transl)].

Embolization of renal arteries (coil embolization by Gianturco) was performed in four patients with malignant renal hypertension as an alternative to bilateral nephrectomy. Three patients with successful renal transplantation developed intractable hypertension without arterial stenosis of the transplant. One patient treated with hemodialysis showed malignant hypertension refractory to volume depletion and antihypertensive therapy. In all cases hypertension could be improved and thus medical therapy be reduced.

Adult↗
PubMed1980

[Percutaneous transluminal catheter dilatation of kidney artery stenoses in patients with renovascular hypertension].

14 patients with severe hypertension showed unilateral (7) or bilateral (6) stenoses of renal artery due to arteriosclerosis (12) or fibromuscular hyperplasia (7); one stenosis appeared after renal transplantation. Successful application of percutaneous transluminal angioplasty of renal artery was performed in 14 stenoses. 4 of 10 patients showed normal values of blood-pressure, in 4 patients blood-pressure was improved, in 2 patients hypertension remained unchanged. The patients were observed 1 to 23 months after dilatation; antihypertensive drugs were necessary in all cases, but could be reduced. The effectiveness of the procedure was demonstrated by renal arteriogram and determination of pre- and poststenotic blood-pressure values.

Adult↗
PubMed1977

[Kidney transplantation from a nephrological-urological viewpoint--results and problems. 2. Diagnosis and therapy after transplantation, complications, long-term results].

Indications, selection of donor and recipient, medical and surgical management and complications, problems of organ procurement. Renal transplantation has become routine therapy. Organs are predominantly obtained from cadavers, transplantations from living donors are rarely indicated. Advances in preservation methods have improved organ quality and prolonged storage time. Selection of the most suitable recipient is based on histocompatibility matching. Blood transfusions before transplantation seem to improve the results. Recognition of a rejection crisis is primarily based on clinical symptoms. Persistent rejection calls for prompt explantation and the patient has to return to dialysis. Infections, serum-hepatitis and gastro-intestinal bleeding are the most common complications. Late complicatons are diabetes mellitus, cirrhosis of the liver, osteopathy, recurring glomerulonephritis, and, rarely, malignomas. Transplantation frequency in the Federal Republic of Germany could be increased by more awareness of physicians and a better knowledge of the general public about the need for cadaver donors.

Graft Rejection↗