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Biomedical subjects

D Seidel

Publications and source records attributed to D Seidel.

329 records · Page 19Linked to original sources
PubMedDate not supplied

MR imaging in multiple sclerosis: comparison with clinical, CSF, and visual evoked potential findings.

MR examinations of 136 patients with multiple sclerosis (MS) were evaluated to correlate the results with clinical, CSF, and visual evoked potential (VEP) findings. In addition, 22 of the 136 patients were studied several times during a 5-month follow-up period. It was demonstrated that MR is superior to CSF and VEP findings in establishing cerebral alterations in MS. A relationship between the results of CSF and VEP examinations and the MR results could not be detected. Negative CSF and VEP results corresponded to positive MR imaging and vice versa. In our series, five negative MR results were obtained in patients with clinically proved MS. The extent of alterations shown up by MR corresponds to the duration of the disease; in particular, more confluent abnormalities in the periventricular region were found in patients with long-standing disease. More plaques were found in patients with a primary relapsing/remitting course of the disease than with the primary chronic progressive form. The clinical course and the grade of disability did not correspond to differences in MR imaging. Follow-up demonstrated that most lesions remain unchanged (72-79%); increases and decreases in the size of the plaques seem to depend on the clinical course. These results suggest that MR is the most sensitive technique for establishing the diagnosis of MS.

Evoked Potentials, Visual↗
PubMedDate not supplied

[Early detection and incidence of iron deficiency in pregnancy].

For early detection of iron deficiency during pregnancy ferritin, transferrin, serum iron, transferrin saturation and red blood cell (RBC) parameters were measured in 156 pregnant women. The geometric mean of ferritin-concentration was 11.7 +/- 2.7 ng/ml (mean +/- 1 s) which is about 46 ng/ml lower than that in non pregnant women. The duration of pregnancy, the number of pregnancies and the interval from the preceding pregnancy were all considered: 67% had iron deficiency, 18% prelatent, 27% latent and 22% manifest. On the basis of RBC analysis only 30% could be detected correctly. Ferritin detected 90% whereas serum iron, transferrin, transferrin saturation only detected 45% of the cases. The serum ferritin level did not correlate with the number of previous pregnancies but it did correlate with the interval to the last pregnancy. Serum ferritin declined sharply until the 28th week of pregnancy but only slightly thereafter. These data suggest at least one determination of serum ferritin concentration in pregnant women for a sufficient prophylaxis of iron deficiency during pregnancy. The latest time for the measurement should be between the 20th and 23rd week. An additional determination of serum ferritin during the early pregnancy is indicated if the time interval to the preceding pregnancy is shorter than three years.

Adolescent↗