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Biomedical subjects

D Seaton

Publications and source records attributed to D Seaton.

22 records · Page 2Linked to original sources

Effect of body position on gas exchange after thoracotomy.

To determine the effect of change in body position on gas exchange after thoracotomy, 12 patients with potentially resectable lung tumours were studied before and 24 hours after operation. Measurements of arterial blood gas tension (PaO2, PaCO2), alveolar-arterial oxygen difference (A--adO2), venous admixture effect (Qs/Qt percent), and physiological dead space to tidal volume ratio (Vd/Vt), were made in the supine, and left and right lateral decubitus positions. Preoperatively, altering position did not affect gas exchange significantly. After thoracotomy in the lateral position with the unoperated side dependent, PaO2 was significantly higher, and A--adO2 and Qs/Qt percent significantly lower than in the supine position. Postoperatively, the lateral position with the side of thoracotomy dependent was usually associated with the worst gas exchange. Only three patients achieved their best postoperative gas exchange in this position. In two this may have resulted from dependent small airway closure during tidal breathing, due to airways obstruction and old age, and in the third from postoperative atelectasis in this unoperated lung. No significant changes in mean PaCO2, Vd/Vt, or minute ventilation (VE) occurred with different positioning.

Aged↗

Regional lung function in asymptomatic cigarette smokers.

Regional pulmonary ventilation and perfusion were studied in the supine posture using xenon-133 in 10 asymptomatic cigarette smokers with normal chest radiographs and no evidence of large airway obstruction. The results were compared with those obtained in age-matched control subjects who were lifelong nonsmokers. The ventilation of the upper zones of the lungs was significantly less than that of the lower zones in smokers but not in control subjects, and perfusion of the upper zones of the lungs was significantly greater than that of the mid-zones in control subjects but not in smokers. It is suggested that the upper zone abnormalities found in the group of smokers were consistent with the development of early emphysema.

Adult↗

Regional lung function in asbestos workers.

Regional lung function was measured using radioactive xenon-133 in a group of normal subjects and in two groups of asbestos workers. When compared with the normal group, patients with pulmonary asbestosis showed impaired ventilation of the lower zones. Subjects with calcified pleural plaques without radiological evidence of lung parenchymal fibrosis did not show this abnormality.

Aged↗