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Biomedical subjects

D Schwarz

Publications and source records attributed to D Schwarz.

At least 73 records · Page 4Linked to original sources
PubMed1976

Stimulation of insulin secretion in man by oral glycerol administration.

The effects of an orally administered glycerol load (1 g/Kg body weight) on blood glucose, plasma FFA, and plasma insulin levels have been determined in eight normal fasting or glucose loaded (1 g/Kg body weight) volunteers. Blood glucose levels were not affected by glycerol loading while glicemia followed the same pattern of a glucose tolerance test in the group treated with glucose plus glycerol. Plasma FFA were significantly lowered only 90 min after glycerol loading while they had markedly and persistently decreased by glycerol plus glucose per os. Finally, though glicemia did not change, insulinemia was markedly increased by glycereol, 90 min after loading; moreover, plasma IRI was significantly higher in the group treated with glycerol plus glucose than in the group treated with glucose alone. These data suggest that the release of insulin may be stimulated by a very small increment of blood glucose, which derives from glycerol.

Adult↗
PubMed1976

[Possibilities of dental health education in the socialist school].

The possibilities of dental health education in the socialist school are dealt with. They consist in the direct influence of the stomatologist and his auxiliaries on the pupils and in the indirect influence via the teachers, educationalists and public organizations. The dental health education in the school must be brought into line with the extra-curricular dental health education. In the school, dental health education may be mentioned in many subjects of instruction. As to the extra-curricular dental health education, it seems that the co-operation with the "Young First-Aiders" is especially important. A planned, concerted action is advisable in dental health education.

Child↗
PubMed1975

Spin-labeling studies of urea-treated leucine aminopeptidase.

1. Leucine aminopeptidase (EC 3-4-11-1) from bovine eye lens was spin-labeled at the most reactive thiol groups with 2,2,6,6-tetramethyl-4-[2-iodoacetamido]-piperidine-1-oxyl. 2. Electron spin resonance spectra show two spectral parts corresponding to two local conformational states in the environment of bound label. One state (A) exhibits a strong immobilizing effect on the mobility of the bound label whereas the other one (B) immobilizes weakly. Independently on the degree of labeling a ratio of A:B approximately 4:1 was estimated. In B a hydrophobic environment of label was observed. 3. Treatment of leucine aminopeptidase by 6.2 M urea leads to the following structural changes. a) An additional weakly immobilizing conformational state (B') with reduced hydrophobic interactions and increased mobility representing an unfolded conformational state appears. B' shows a time-dependent increase of its extent at the expense of B and A' (half conversion time about 0.5 h). The extent of this conformational change is larger, if the enzyme is additionally complexed with Mn2+. b) Mn2+ complexed with the protein is partly released producting hydrated Mn2+. c) After withdrawal of urea the observed conformational changes in leucine aminopeptidase are fully reversible, giving the initial ratio of A:B approximately 4:1 even after long incubation. 4. 6.2 M urea is not able to destroy the strongly immobilizing conformational state A completely.

Animals↗
PubMed1973

Glycerol metabolism.

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Administration, Oral↗