The goal of this study is to determine and localize the generators of different components of middle latency auditory evoked potentials (MLAEPs) through intracerebral recordings in auditory cortex in Human (Heschl's gyrus and Planum Temporale). The intracerebral data show that the generators of components at 30, 50, 60 and 75 msec latency are distributed medio-laterally along the Heschl's gyrus. The 30 msec component is generated in the dorso-postero-medial part of the Heschl's gyrus (primary area) and the 50 msec component is generated laterally in the primary area. The generators of the later components (60-75 msec) are localized in the lateral part of the Heschl's gyrus that are the secondary areas. The comparison with the generators of the components of the magnetic auditory evoked field and the tonotopic organization of the auditory cortex are discussed.

Acoustic Stimulation↗

PubMedDate not supplied

The role of infusional chemotherapy and radiation in organ preservation.

Chemotherapeutic agents, used alone or in combination, have had a largely palliative effect in the treatment of solid tumors. The curative ability of these agents has been limited to about 15% of cases, in large measure due to chemotherapy's failure to accomplish locoregional control, leaving surgery or irradiation for local control of primary disease as modes of treatment. In many cases, however, surgery is not a feasible alternative, and radiation therapy may fail because of radioresistance. Whether this is caused by anoxia or by the innate radioresistance of the tumor cell, radiation oncologists have tried a number of methods to overcome the resulting insensitivity. Experience with the continuous concomitant infusion of various cytotoxic agents and radiation therapy in the treatment of advanced malignancies has been encouraging. The resultant radiosensitization has let to an increased rate of locoregional clearance of advanced carcinomas with a worthwhile increase in survival rates. The use of infusion chemo- and radiation therapy also has allowed the use of an organ-sparing program in all but the most advanced stages. There are already encouraging reports on successful organ-sparing treatment programs for carcinoma of the anus, esophagus and bladder. (ABSTRACT TRUNCATED)

Antineoplastic Combined Chemotherapy Protocols↗

PubMedDate not supplied

Doris Schwartz: a living legend. Interview by Priscilla Ebersole.

Doris Schwartz has been outstanding in many ways: the only nurse and only woman to receive an invitation to participate in the World Health Organization Committee on Aging and Geriatric Care held in Geneva in 1965; the codirector of the first Primex program to prepare geriatric nurse practitioners in 1976; the first nurse to receive a Fogerty Fellowship; and the first to be invited to work with Sir Ferguson Anderson and to participate in planning the care of the aged in Scotland. From this experience a fine textbook in gerontology and geriatric nursing emerged, possibly the first to combine the medical and nursing viewpoints in the care of the aged. In the early 1980s Ms. Schwartz expressed her indignation in a letter to Geriatric Nursing regarding the lack of clinical research investigating the implications and inhumane effects of tying up our elderly. Two young faculty researchers, Neville Strumpf and Lois Evans, took up the challenge and began a decade of extensive research into the use of restraints. Ms. Schwartz always seems to have been at the hub of clinical practice issues that affect quality of life. The following excerpts from an interview with Doris Schwartz will introduce our readers to her personal perspective.

Faculty, Nursing↗