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Biomedical subjects

D Schwander

Publications and source records attributed to D Schwander.

At least 37 records · Page 2Linked to original sources
PubMed1988

[Sedation].

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Aged↗
PubMed1986

[Tolerability and pharmacokinetics of an intravenous immunoglobulin preparation in immunologically normal subjects and tolerability in patients with hypogammaglobulinemia resulting from chronic lymphatic leukemia].

Tolerance, clinical effects and kinetics of an unmodified immunoglobulin preparation for intravenous use were investigated in 4 patients with advanced chronic lymphocytic leukemia. Previously, good tolerance of the preparation had been found in 49 immunologically normal patients. The four patients with secondary humoral immunodeficiency received doses of 140-360 mg IgG/kg per infusion as outpatients at monthly intervals. With one exception, no acute infections (pneumonitis), as commonly seen before, were observed during the observation time of 24 to 68 weeks, and the pre-existing chronic infections (bronchitis, sinusitis etc.) remained compensated without antibiotics. In all four patients tolerance of the preparation was good. In all cases of hypogammaglobulinemia a dose-dependent increase in the serum IgG concentration was observed immediately after the infusion. However, persistence of the serum IgG increase showed considerable interindividual differences. The half life of the tetanus and HBs antibodies (21.7 to 34.4 and 19.7 to 25.7 days respectively) found in 4 healthy volunteers is within the biological range. This indicates an unmodified structure of the antibodies of the IgG class contained in the preparation used.

Adult↗
PubMed1985

The TUTOR, a software package for educational computing.

Computer Assisted Instruction (CAI) is an effective method of imparting factual knowledge relating to the practice of medicine. Unfortunately educational software remains scarse and expensive or lacks flexibility. This paper introduces a software package that permits continuing medical education and self assessment by Multiple Choice Question exercises. The questions are first written to a text file with an easy-to-use editor. The programs are written in BASIC and hardware prerequisite are a desk-top computer with 32K of CPU memory and a dual floppy disk drive.

Computer-Assisted Instruction↗
PubMed1984

[Intravenous sedation for gastroscopy: comparison between midazolam and diazepam].

Benzodiazepines are often used as premedication or intravenous sedative agents for endoscopies. The present study included 74 patients. It compared the sedative and amnestic properties of midazolam and diazepam, their relative potencies as well as the comfort of both the patient and the endoscopist during gastroscopy. The comparison has shown some statistically significant differences, allowing the following conclusions: amnesia was more frequent with midazolam; the dose requirement (in mg X kg-1) for adequate sedation was more important with diazepam, confirming the greater potency of midazolam; generally speaking, sedation was excellent with both drugs.

Adolescent↗