Search PubMed⌕ Search

Biomedical subjects

D Schuler

Publications and source records attributed to D Schuler.

At least 145 records · Page 8Linked to original sources
PubMed1976

Therapeutic results: report of the Hungarian children's leukaemia study group.

In Hungary, the morbidity of leukaemia in children aged 0 to 15 years is 3.6/100,000. The rate of complete remission was 88.5% in ALL and 57.1% in AML. The most important factors limiting survival were infections acquired during induction therapy in 91.3% and during Co irradiation in 66.3% of the patients.

Adolescent↗
PubMed1976

Leucocyte migration in presence of leukaemia-associated antigens in children with Down's syndrome.

The effect of leukaemia-associated antigens prepared from leukaemic lymphoblasts and myeloblasts has been studied on the migration of peripheral leucocytes obtained from children with Down's syndrome. Membrane extract from leukaemic lymphoblasts had no effect, while that from leukaemic myeloblasts was slightly inhibitory, i.e. it was "recognized" as antigen by the lymphocytes of children with Downs syndrome.

Adolescent↗
PubMed1976

Cross-resistance of transformed mouse cells to some drugs.

The Colcemid-resistant L--53 cell strain was examined for cross-resistance to metaphase inhibotors (Vincristine, Vinblastine, estradiol-17beta), an antitumor antibiotic (Rubomycin C) and an alkylating agent (Lycurim), compared with the Colcemid-sensitive L cells. The L-53 cells proved to be resistant besides colchicine to Vincristine, Vinblastine and estradiol-17beta concerning their antimitotic effect. The comparison of the viability of L and L-53 cells in the presence of Rubomycin C and Lycurim showed a resistance of the L-53 cells to Rubomycin C, while the effect of Lycurim was the same on both cell lines. The chromosome-mutagenic action of Lycurim was also equal on both cell lines.

Alkylating Agents↗
PubMed1975

Rosette formation in acute lymphoid leukaemia.

The capacity of leukaemic lymphoblasts and remission lymphocytes, obtained from 40 children with acute lymphoid leukaemia, to form sheep red blood cell rosettes was investigated. Lymphoblasts isolated from the peripheral blood of the patients prior to antileukaemic treatment showed greatly reduced numbers of rosette-forming cells as compared to controls (4.6% vs. 27.5%). The ratio of rosette-forming cells during intensive induction chemotherapy was still significantly lower than the control value (15.7%), while after the achievement of complete remission the number of RFC approximated the normal value (22.5%). The presence of leukaemic serum had no significant effect on the number of RFC.

Cell Transformation, Neoplastic↗