Biomedical subjects

D Sauvage

Publications and source records attributed to D Sauvage.

At least 55 records · Page 3Linked to original sources

PubMed1982

[Crying spasm].

Explore the source record for details and available documents.

Apnea↗

PubMed1981

Epidemiological and serological study of hepatitis A virus outbreaks in France: a comparison between immunoadherence and radioimmunoassay.

An epidemiological study and the simultaneous evaluation of anti-HAV antibody using radio immunoassay (RIA) and immunoadherence hemagglutination assay (IAHA) was performed during three hepatitis A epidemics in the Tours area (France). Fifty-seven sera from 35 subjects with viral hepatitis type A and 16 sera from nine children who did not develop any clinical signs of hepatitis were studied. The more explosive epidemic occurred in an institution for mentally retarded children (attack rate 68%). The two major outbreaks observed were due to the introduction of the institutions of individuals infected with hepatitis A virus. Two out of three of the index cases had a seafood dinner three to four weeks before onset of jaundice. Sera taken one week after jaundice were always found to be anti-HAV positive by both RIA and IAHA, and sera taken more than three days before the appearance of jaundice were negative by both methods. Sera taken at the peak of the transaminase elevation were anti-HAV positive by RIA but only one out of two were positive by IAHA. The anti-HAV titre by RIA increased from the time of the appearance of jaundice and the highest titres, over 1/20000 were seen only after several months. Observations of subjects in close contact with patients who seroconverted without any manifestation of hepatitis, confirmed the existence of clinically mute infections.

Adult↗

PubMed1978

[Autism, inhibition, electrophysiology and biochemistry].

The term "inhibition" is not usually employed in the psychopathology of schizophrenia. However, in defining some neuroleptics' action, the work "desinhibition" is currently used and Pavlov explained the main features of the schizofrenic syndrome through a transmarginal inhibition mechanism. The purpose of this study is to investigate if an inhibition process underlies some phenomena shown up by the evoked potentials (EPs) method. Usually, a lower EPs' amplitude is seen in schizophrenic patients than in normals. This phenomenon is displayed by: -- simple stimuli EPs: they show weak amplitude and high variability; -- double-shock EPs: they have a long recovery-cycle; -- conditioned EPs: their amplitude is minimally augmented by coupling the conditioned and the unconditioned stimulus; -- EPs in experiments with increasing-intensity stimuli: their amplitude decreases as stimulation intensity increases. Some of these concurrent data could indicate a transmarginal inhibition, particularly the lengthening of the recovery cycle and the amplitude-reduction phenomenon. Although these are preliminary results, nevertheless some relationships emerge between clemical, electrophysiological and biochemical data.

Brain Chemistry↗

PubMed1978

[Modifications in urinary homovanillic acid after ingestion of vitamin B6; functional study in autistic children (author's transl)].

Basing their study on the investigations which led to the dopaminergic theory of the psychoses, the authors studied homovanillic acid (principal derivative from dopamine) levels in the urines of 37 autistic children, and 11 normal children acting as controls. The favourable action of vitamin B6 on autism, reported by anglosaxon authors, was confirmed in 15 of the children. Furthermore, vitamin B6 reduces homovanillic acid levels in 33 autistic chilren and increases them in all the control group children.

Autistic Disorder↗

PubMed1974