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D Sautereau

Publications and source records attributed to D Sautereau.

71 records · Page 4Linked to original sources
PubMed1989

Theophylline toxicity risks and chronic renal failure.

Serum theophylline and metabolites (methyluric acids, mono- and dimethyl xanthines) concentrations from uremic patients, either with end-stage renal failure or on peritoneal dialysis or maintenance hemodialysis, were investigated by HPLC and compared with those obtained in non-uremic subjects. We conclude that in uremic patients serum theophylline metabolites, particularly serum 1,3-dimethyluric acid, are significantly higher than in non-uremic subjects even when serum theophylline is lower. A slight increase in the free fractions of serum theophylline was also observed in these patients. All these findings could explain the toxicity signs noted in some patients with chronic renal failure and treated with very low doses of theophylline.

Adult↗
PubMed1988

[Glaphenine biliary lithiasis. Identification by infrared spectrophotometry].

The authors report the case of a woman, presenting with choledocholithiasis essentially composed of glafenic acid. Identification of the drug and its metabolites was demonstrated using infrared spectrophotometry and thin layer chromatography. To our knowledge, this is the first publication of drug choledocholithiasis.

Aged↗
PubMed1987

Ultrasonographic anatomy of the liver.

Two characteristics of the ultrasonic image, that it is rebuilt and non figurative in its details, led us to establish specific relationships between anatomic structures and their ultrasonic images. The anatomic study was made on fresh, injected, frozen, livers, sectioned along the classical echographic planes. The echographic study was conducted in healthy patients, without any hepatic lesions. The results fall under three heads: analysis of the basic structures (portal vein, hepatic vein, and bile ducts) enables to establish perfect relationship between the anatomic and echographic features; the echo-anatomic study of the echographic planes pertaining to percutaneous examination of the liver provides a satisfactory correlation between the anatomy and the ultrasonogram; analysis of the hepatic vascular arrangement enables to define a sectorial systematization of liver structure. Segmental systematization of the right side of the liver is more difficult to define because of the virtual limits of the upper and lower segments of the right paramedian and lateral sectors. This study leads to better echographic understanding of the liver and to a tentative systematization essential to the localization of focal hepatic lesions.

Bile Ducts↗
PubMed1987

Value of sonographically guided fine needle aspiration biopsy in evaluating the liver with sonographic abnormalities.

This retrospective study was undertaken to evaluate the diagnostic usefulness of 97 sonographically guided fine needle aspiration biopsy cytologies in 92 patients with one or more hepatic lesions suspicious of malignancy. Results of the fine needle aspiration biopsy were then compared with the definitive results obtained by histologic examination, or with the subsequent course of the patient. A final diagnosis of malignancy was established in 65 cases, of which fine needle aspiration biopsy cytology revealed a concordant diagnosis in 54 cases. The diagnostic sensitivity of this technique was 83% for malignant lesions with 93% specificity. Of the 54 cases with malignant cytology, it was possible to distinguish between a primary or secondary lesion in 31 cases (57%). Benign lesions were aspirated in 32 cases, of which 30 cases concorded with the final diagnosis. This study confirms the usefulness of sonographically guided fine needle aspiration biopsy cytology in diagnosing malignant hepatic tumors.

Adult↗
PubMed1987

[Hepatic involvement in secondary syphilis].

A case of secondary syphilitic hepatitis is reported. A 49-year old woman was admitted for weight-loss, fever, hepatomegaly and splenomegaly. Diagnosis of syphilitic hepatitis was based on cholestasis associated with positive serologic tests for syphilis without other immunological disturbances. Biopsy of the liver showed a moderate infiltration in and around the portal tracts. Immunofluorescence study for treponema was negative. Rapid improvement was obtained with penicillin initially associated with steroid therapy. Liver involvement in secondary syphilis is characterized by anicteric cholestasis, an inflammatory syndrome, and periportal infiltrate inconstantly associated with centrilobular necrosis, granulomatous reaction and presence of treponemas in the lesions. Due to the increasing frequency of sexually transmitted diseases, this diagnosis could become more frequent.

Female↗
PubMedDate not supplied

[Developmental adrenal tuberculosis. Value of x-ray computed tomography].

Two cases of Addison's disease secondary to active adrenal tuberculosis are reported. Computed tomography showed hypertrophy of the adrenal gland, which was bilateral in one case and unilateral in the other. Repeat computed tomography scans during antituberculous chemotherapy demonstrated a progressive change of the adrenals toward atrophy and calcification, while the adrenal function remained impaired. The authors recall that adrenal tuberculosis may be unilateral first, then bilateral, and that the gland is initially hypertrophic before hormonal deficiency appears; later on, adrenal atrophy and calcification develop. Computed tomography seems to be useful in the aetiological diagnosis of Addison's disease. Moreover, it helps in determining whether or not antituberculous therapy is indicated, which is not always easy to decide in the absence of "active" focus. The finding, with or without positive tuberculin skin tests, of an adrenal hypertrophy unexplainable by any other pathology (e.g. metastasis, histoplasmosis) should call for antituberculous treatment, especially since it sometimes results in recovery of adrenal function.

Addison Disease↗
PubMedDate not supplied

[The value of ultrasound-guided cyto-biopsy in the study of livers with abnormal ultrasonograms].

This retrospective study considers the diagnostic reliability of 97 cyto-biopsies performed with a fine needle and guided by ultrasonography in 92 patients with one or several suspicious liver lesions. The results of the cyto-biopsy were compared with the final diagnosis obtained by histological examination or by the evolution. In 65 confirmed malignant tumors, fine needle biopsy was concordant in 54 cases. The sensitivity of this method in the diagnosis of malignant liver lesions was 83% with a specificity of 93%. In 54 malignant cytologies, the differentiation between primary or secondary lesions was possible in 31 cases (57%). In 32 confirmed benign lesions, fine needle biopsy was concordant in 30 cases. This study confirms the advantage of cyto-biopsy guided by ultrasonography in the positive and etiological diagnosis of malignant liver tumors.

Adult↗