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Biomedical subjects

D Samuel

Publications and source records attributed to D Samuel.

At least 307 records · Page 17Linked to original sources
PubMed1975

Amyloid-related serum component (protein ASC) IN LEPROSY PATIENTS.

The presence of amyloid-related serum component, protein ASC, in serum samples from 63 leprosy patients was investigated. Protein ASC was detected in 38% of the patients. A correlation to the disease spectrum of leprosy was apparent: polar lepromatous cases, 64% positive; borderline lepromatous, 50%; borderline tuberculoid, 36%; subpolar tuberculoid, 17%; and polar tuberculoid, negative. Antibody activity against the a antigen of Mycobacterium leprae was also determined, showing a similar correlation to the disease spectrum. Serum samples from 23 apparently healthy Ethiopians serving as controls showed a protein ASC incidence of 22%. This figure is significantly higher than the frequency found by others among healthy Norwegian blood donors. Immunoglobulin M levels among patients were elevated in the borderline lepromatous and poplar lepromatous groups. The three tuberculoid groups did not differ in this respect from the control group but were all elevated as compared to a normal Caucasian serum pool. Although raised immunoglobulin M levels seemed to parallel increased frequencies of protein ASC in the patient groups as well as in controls, this correlation might be only secondary to a primary derangement in T-cell function.

Adult↗
PubMed1975

In vivo measurement of variations in the oxygen 18 content of water in rat brain.

A method of analysis for oxygen 18 is described, based on the anodic oxidation of specially prepared tantalum wires implanted through cannulas into the tissue of living animals. The thin anodic oxide layer formed on these wires is then analyzed by the 18O(p,alpha)15N reaction. The isotopic oxygen concentration of water in the brain obtained by this method compares very well with the values obtained by conventional analysis using mass spectrometry. This in vivo method of nuclear microanalysis has been used in both metabolic and equilibration experiments involving oxygen 18. The half-life for the turnover of 18O in body water was found to be about 3 days. A simple three-pool model is presented which can account for the experimental results obtained from the dilution by body water of interperitoneally injected water highly enriched in 18O.

Animals↗