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Biomedical subjects

D S Wilkinson

Publications and source records attributed to D S Wilkinson.

At least 55 records · Page 3Linked to original sources
PubMed1980

Some spiro analogues of the potent analgesic ketobemidone.

A series of spiro analogues of the potent narcotic ketobemidone have been prepared and found to be devoid of opiate activity. Additional pharmacology and possible implications for the mode of binding of ketobemidone to the analgesic receptor are discussed.

Analgesics↗
PubMed1980

A 10-year review of an industrial dermatitis clinic.

During a 10-year period, 678 patients were seen at an occupational dermatitis clinic attached to a District General Hospital. Of these, 424 were accepted as having an occupational dermatosis. The pattern of skin lesions and the patch test findings were those associated with a diversified light industrial setting coupled with a large traditional furniture industry. Fifty-one per cent of all cases were regarded as being allergic but the proportion varied greatly from one industry to another. Positive patch tests were obtained to the Standard European Series in 50.3% but additional tests increased this to 64%. In the furniture industry most of the positive reactions occurred only with such additional tests. The significance of the patch test reactions is discussed in relation to the findings in 992 unselected patients seen in the contact dermatitis clinic during a 3-year period.

Dermatitis, Atopic↗
PubMed1980

Comparison of patch test results in two adjacent areas of England. II. Medicaments.

A 3-year study of patch test reactions to the Standard European Battery (S. E. B.) has been carried out in two adjacent areas of South-east England with the same climatic and cultural background. The source of materials and method of testing were identical; all observers have worked together in the same Contact Dermatitis Clinic and the interpretation of reactions can therefore be considered to be consistent. The main differences between the two areas lay in the pattern of employment and in local prescribing habits. Only the second aspect is considered here. Seven allergens--lanolin, neomycin, parabens, iodochlorhydroxyquinoline, ethylene diamine, caine 'mix' and chlorocresol--accounted for approximately 30% of all positive patch test reactions. 'Medicament sensitivity' correlated well with the known prescribing habits of both regions. Certain sites were shown to be especially important in the pathogenesis of medicament contact sensitivity.

Drug Eruptions↗
PubMed1979

Perioral dermatitis: a 12-year review.

A continuing study of perioral dermatitis over a period of 12 years is presented. A distinction is made between various patterns of circumoral and paranasal dermatitis and the clinical picture that we describe as "perioral dermatitis". No cases were seen before 1966 but the number of patients presenting to hospital clinics or in private practice rose dramatically until 1970-1972, after which there has been a progressive fall in numbers. In this period, 259 patients were diagnosed as having the condition and of these 203, resident in an area of some 275,000 population and seen by one or other of us on at least two occasions, form the basis of this study. There were 173 females, fifteen males and fifteen children under 12 years of age. In many cases it was possible to suggest the primary lesion for which patients sought treatment. In sixty-nine patients this consisted of a para-oral eruption on the side of the chin and, in forty-one a paranasal erythematous dermatitis. The characteristic appearance and spread of the eruption to the glabella and eyelids are described. A few patients, mostly male, showed lesions around the eyelids only, from treatment of seborrhoeic dermatitis. All but nine of the patients acknowledged the use of potent (not necessarily fluorinated) topical corticosteroids over long periods; in many cases these were self-administered. Some of the children had been treated with preparations intended for their mothers. The numerous aetiological agents that have been incriminated as causes of this eruption are examined. We believe that the prolonged use of topical potent corticosteroids is the only one tenable from our observations. The role of hormonal factors and of local irritant agetns is examined in this context. Tetracyclines are curative in the great majority of patients in 6 weeks if local corticosteroids are discarded. Relapses are rare. Perioral dermatitis is a most satisfying condition to treat but several questions remain unanswered. The current "revolt" against all forms of cortisone may enable us to answer some of these in the near future.

Administration, Topical↗
PubMed1979

Thiomersal.

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Dermatitis, Contact↗
PubMed1979

Comparison of patch test results in two adjacent areas of England-I. (Industrial allergens).

A 3-year study of patch test reactions to the Standard European Battery has been carried out in two adjacent areas of S. E. England with the same climatic and cultural background. The source of materials and method of testing were identical; both observers had worked together in the same Contact Dermatitis department and the interpretation of reactions can therefore be considered to be consistent. The main differences between the two areas lay in the pattern of employment and of local medicament prescribing. The first only is examined here. One area was dominated by the automobile industry, the other by the furniture industry, with important subsidiary rubber, foam and electronics factories. The pattern that emerges shows that patch test reactions to the Standard European Battery were more likely to be related to environmental allergens and medicament usage than to industrial hazards. Chrome dermatitis was less common than elsewhere in Europe but nickel sensitivity showed the same pattern. Rubber chemical sensitivity reflected industrial, as well as domestic usage. Colophony and formaldehyde appeared to have less industrial significance than we expected. Special additional industrial allergens are not considered here but were of particular importance in the furniture industry. Although the numbers analysed were relatively small, we believe that they reflect the pattern to be expected in areas of relatively low industrial risk in Great Britain at the present time.

Allergens↗