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Biomedical subjects

D S Sheriff

Publications and source records attributed to D S Sheriff.

At least 37 records · Page 2Linked to original sources

Libyan family with beta-thalassemia trait associated with hypercholesterolemia with widespread xanthomas.

We describe a Libyan family with beta-thalassemia trait associated with unusually high concentrations of hemoglobin A2 and hypercholesterolemia. The family consists of the father, mother, and three sons. The marriage was consanguineous. The concentrations of total cholesterol and low-density lipoprotein cholesterol in serum were very high in two sons who also had widespread xanthomas. The erythrocyte membranes showed a high cholesterol/phospholipid ratio, with no significant susceptibility to lipid peroxidation in vitro.

Adult↗

Semen analyses in Hansen's disease.

Disturbances in semen quality can be induced by exogenous factors including trivial illnesses like throat infection and viral infection with fever. Hansen's disease presents with problems such as long term dependence on drugs, hyperthermia, haemolysis and anxiety due to social stigma. In the present study the semen quality of patients with tuberculoid-type leprosy was studied during and after withdrawal of therapy. Patients generally had low sperm counts and spermatozoal motility was low with a greater number of abnormal forms compared with control subjects. Patients did not show a circannual variation in their sperm count as was observed in controls. The patients were oligozoospermic during their first year of medication, showing improvement in subsequent years.

Adolescent↗

Embryo research.

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Embryo, Mammalian↗

Erythrocyte glucose-6-phosphate dehydrogenase status of newborns and adults in eastern Libya.

One hundred and twenty cord and 320 venous blood samples were collected from Libyan newborns and adults respectively for the estimation of glucose-6-phosphate dehydrogenase (G-6-PD) activity by a screening technique and by quantitative estimation. The mean (S.D.) enzyme activity in the non-deficient neonates and adults was 1.13 (0.23) and 0.87 (0.21) IU/ml RBC/min respectively. The incidence of G-6-PD deficiency in the male population was 2.8%. The enzyme activity in the deficient male population ranged from 0-19.5%; none of them was symptomatic or had haematological abnormality. Of the female subjects 1.8% had enzyme activity of 50-65%. The frequency of enzyme deficiency appears to be low compared with that found in other Arab populations and is comparable with the incidence in other mediterranean countries.

Adult↗