Actinomycin D and hepatic polyribosomal disaggregation. Evidence for different half-lives of mRNA of free and membrane-boudn polyribosomes.
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Animals↗
Biomedical subjects
D S Sarma
Publications and source records attributed to D S Sarma.
The selective effect of actinomycin D on free polyribosomes of mouse liver.
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Animals↗
Studies on orotic acid fatty liver in rats: factors influencing the induction of fatty liver.
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Adenosine Triphosphate↗
Evidence for two types of phosphorylation of proteins.
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Amino Acids↗
Effect of dietary tryptophan on hepatic polyribosomes and protein synthesis in fasted mice.
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Adrenal Glands↗
The influence of tryptophan on hepatic polyribosomes and protein synthesis in fasted mice.
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Animals↗
Biotin deficiency and orotic acid fatty liver in the rat.
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Animals↗
Cholesterol synthesis in orotic acid fed rats.
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Acetates↗
pH dependent nicotinamide toxicity in Aspergillus niger.
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Amidohydrolases↗
Dietary orotic acid, a new selective growth stimulus for carcinogen altered hepatocytes in rat.
It was observed that orotic acid (OA), a precursor for pyrimidine nucleotide biosynthesis, when supplied exogenously at 1% level in the diet selectively stimulated the growth of hepatocytes modified by 1,2-dimethylhydrazine (1,2-DMH) to form gamma-glutamyltransferase (gamma-GT) (EC 2.3.2.2) positive islands. Increasing the duration of OA diet from 5 to 10 weeks resulted in an increase in the number of foci from 6 to 14/cm2. Rats that received the carcinogen and basal diet, however, developed only 1-2 foci/cm2. This unique effect of OA can be further accentuated by supplying a liver cell proliferative stimulus, such as a single necrogenic dose of CCl4.
Animal Feed↗