Biomedical subjects

D S Rampton

Publications and source records attributed to D S Rampton.

112 records · Page 7Linked to original sources

PubMed1974

The effects of pentobarbitone anaesthesia on the volume and composition of the extracellular fluid of dogs.

1. The effects of pentobarbitone sodium (Nembutal) anaesthesia in dogs on extracellular fluid and plasma volumes, plasma protein concentration, haematocrit and extracellular fluid electrolyte composition were measured.2. Induction of pentobarbitone anaesthesia caused a rapid rise in extracellular fluid volume, accompanied by decreases in the haematocrit, in extracellular fluid potassium concentration, and in plasma calcium, magnesium, and protein concentrations. There were no significant changes in plasma osmolality and extracellular fluid concentrations of sodium and chloride.3. Extracellular fluid volume did not alter significantly during six hours of anaesthesia, but the haematocrit and extracellular fluid potassium concentration showed an increase towards control values.4. The relevance of these findings to the interpretation of experiments carried out under pentobarbitone anaesthesia is noted.

Anesthesia, Intravenous↗

PubMed1974

The effects of the production of sodium depletion by peritoneal dialysis with 5 percent glucose on the volume and composition of the extracellular fluid of dogs.

1. The volumes and compositions of the extracellular and peritoneal fluids were monitored in functionally nephrectomized dogs during a period of 4 hr of peritoneal dialysis with 5% glucose.2. The extracellular fluid volume ([(14)C]mannitol space), sodium, potassium and chloride concentrations decreased, while the peritoneal fluid volume, sodium, potassium and chloride concentrations increased.3. Movement of water from the e.c.f. to non-extracellular sites occurred, reaching a maximum after 1 hr; thereafter, the movement of water was first reduced, and later reversed.4. From the volumes and compositions of the extracellular and peritoneal fluids, the total contents of solutes in the two compartments were calculated.5. There was a mobilization of sodium and chloride from non-extra-cellular sites, which became significant after 2 hr of dialysis, and increased throughout the remainder of the period of dialysis.6. The physiological significance of these changes is discussed.

Animals↗

PubMedDate not supplied

Is the rectum usually empty?--A quantitative study in subjects with and without diarrhea.

The authors have investigated the frequency with which the rectum contains feces by recording the presence or absence of fecal contamination of the membrane or of discoloration by feces of the contents of dialysis bags placed in the unprepared rectum for one hour. Feces were present in the rectum in 31 per cent of 32 studies in normal control subjects, in 49 per cent of 80 studies in obese subjects (P less than 0.05 from controls), in 36 per cent of 28 studies in patients with the irritable bowel syndrome, and in 31 per cent of 103 studies in patients with ulcerative proctocolitis, whether or not they had diarrhea. Fecal staining of the bag and its contents occurred much more frequently in 27 studies in subjects with various other diarrheal diseases (67 per cent, P less than 0.02 from controls), including eight with steatorrhea (87 per cent, P less than 0.02 from controls). The frequency with which feces were present was unaffected by age, sex, or time of day of the study. These results provide quantitative support for the assertion that in subjects without diarrhea the rectum is usually empty. In patients with diarrhea or steatorrhea and no distal large intestinal inflammation, however, the rectum usually does contain fecal material.

Adolescent↗

PubMedDate not supplied

The effect of propranolol on the pressor response to exercise in coarctation of the aorta.

In a patient with coarctation of the aorta, blood pressure and heart rate were measured during graded exercise on a bicycle ergometer. After no treatment, and after oral hydrallazine, exercise produced large rises in systolic and diastolic blood pressures, and in heart rate. During exercise after oral propranolol, systolic and diastolic pressures did not increase, and there was a less marked tachycardia. These results suggest that propranolol should be used to minimize the dangers of elevated blood pressure associated with exercise in patients with coarctation.

Administration, Oral↗