Biomedical subjects

D S Karcher

Publications and source records attributed to D S Karcher.

21 records · Page 2Linked to original sources

PubMed1982

Giant lymph node hyperplasia involving the thymus with associated nephrotic syndrome and myelofibrosis.

Giant lymph node hyperplasia (GLH) is an unusual form of benign lymphoid hyperplasia which, although it often occurs in the mediastinum, has not previously been reported to involve the thymus. In this report, a case of GLH with involvement of the thymus and with associated nephrotic syndrome and myelofibrosis is presented. The significance of the association of these conditions with GLH is discussed, including the possibility that some or all of the patient's abnormalities may have been related via an abnormal immune mechanism.

Adult↗

PubMed1978

Malignant histiocytosis occurring in patients with acute lymphocytic leukemia.

Five cases of malignant histiocytosis (MH) in patients being treated for acute lymphocytic leukemia (ALL) have been previously reported. Two additional cases are described here, all known cases are reviewed, and the phenomenon is discussed. The most tenable explanation for this phenomenon appears to be that ALL and MH may have been interrelated in these patients with both diseases originating from a common stem cell.

Adolescent↗

PubMedDate not supplied

Low grade lymphomas in the elderly.

Aging is considered to play an important role in the pathogenesis of non-Hodgkin's lymphoma (NHL). Recent epidemiological studies, both in the United States and worldwide, show an increasing incidence of NHL, with the increase also marked in the elderly population. Two hundred thirty-two patients with NHL, aged 60 years and older (44 percent female and 56 percent male), have been analyzed retrospectively. These patients represented 39 percent of all NHL cases seen over a seven-year period at a single institution. Among the elderly cases, 81 (35 percent) were classified as low-grade NHL, with 44 (19 percent) small lymphocytic lymphoma/chronic lymphocytic leukemia, 2 (1 percent) small lymphocytic lymphoplasmacytoid, 13 (6 percent) diffuse small cleaved including mantle cell, and 22 (9 percent) follicular small cleaved and mixed cell types. Although the indolent lymphomas are currently treated similarly, recent studies indicate differences in pathogenesis and survival among the classic subtypes. Also, several new low-grade clinicopathologic entities have been described. The clinical, morphologic, immunophenotypic, and genetic features of the classic and newer low-grade lymphomas are discussed.

Aged↗