Search PubMed⌕ Search

Biomedical subjects

D S Gordon

Publications and source records attributed to D S Gordon.

At least 73 records · Page 4Linked to original sources
PubMed1982

A report of six surgically treated cases.

Six cases of brain-stem hematoma are described. The clinical presentation in these cases was extremely variable. Operative evacuation of the hematoma resulted in immediate improvement in all cases, and a full or nearly full recovery in five. Untreated brain-stem hematoma is probably always fatal, whereas surgical evacuation is effective and safe. The diagnosis of brain-stem hematoma should be considered in any case of brain-stem lesion.

Adolescent↗
PubMed1981

The immunological and cytochemical characterization of T-cell lymphoproliferative diseases.

Surface markers, terminal transferase, cytochemical staining, and function of peripheral blood lymphocytes were examined in nine patients with T-cell lymphoproliferative disease. Anti-T-cell antiserum proved useful in characterizing the phenotypes of the abnormal cells when only a minority of the abnormal cells formed E-rosettes. Anti-B-cell antiserum was consistently unreactive with the abnormal cells. Terminal transferase was elevated in T-cell ALL but low in T-cell CLL, lymphoma-leukemia, or Sézary syndrome. Lymphocyte proliferative response to nonspecific mitogens was generally depressed as was the response to allogeneic cells. The cells also failed to stimulate in mixed lymphocyte culture, implying a lack of Ia antigens on their surface. Acid phosphatase stain was positive in three patients tested. Peroxidase and esterase stains were negative, whereas PAS was positive in five of eight patients tested. Prognosis in general, regardless of the clinical picture, (ie, acute, chronic, or lymphoma-leukemia), was poor with seven of the nine patients dying within 14 months of diagnosis. Therefore, the use of anti-T-cell antisera and the E-rosette surface marker should be used to characterize the phenotype of the malignant cells in lymphoproliferative disease to enable more vigorous treatment of those that are of T-cell origin and that therefore carry a poor prognosis.

Antigens, Surface↗
PubMed1980

Cranioplasty in children.

In children, acquired skull defects often close spontaneously. This is most likely to take place when the dura mater and the pericranium are intact. Congenital skull defects rarely close spontaneously. Cranioplasty will be needed when a bone defect has failed to close or when it is unlikely to do so. Various methods are available: autogenous bone, acrylic resin, and metal prostheses have been widely used. A series of 68 operations performed on children under the age of 15 years is reviewed. It is concluded that shaped titanium plates are usually preferable. These can be formed by hand, or in a pressure chamber; simple defects can be closed with ready-made titanium strips. Fixation by screws is recommended. Titanium plates have been used successfully even in very young children.

Adolescent↗
PubMed1980

[Adrenergic lung structures following an endogenous and exogenous increase in body serotonin levels].

Adrenergic structures of lungs in 50 mature cats at intraperitoneal serotonin administration and at a short alveolar hypoxia were studied by methods of Falck and Hillarp in the modification of E. M. Krokhina, by argentaffine reaction of Masson--Fontana for serotonin and by histochemical tetrasolium method of Glenner for monoamine oxidase (MAO) activity. Hypoxia 20--30 min duration was produced by means of ligating the inferior-lobular bronchus of the left lung under artificial breathing and the respiratory apparatus A(untypable) under ether narcosis. With changing serotonin level in the organism, the luminescent character of amine-containing and neural structures in the lung change, too. The lung cells of phagocytic nature were stated to be able to absorb and inactivate monoamines of serotonin type. A complete coincidence of topography of luminescent amine-containing structures and formasan granules determining MAO was obtained. Short-term alveolar hypoxia resulted in increasing content of diffuse serotonin in the lung tissue. Endogenic and exogenic increased level of serotonin in the organism resulted in increased MAO activity in the lung tissue.

Adrenergic Fibers↗
PubMed1979

Progressive visual failure in acromegaly following external pituitary irradiation.

Four out of twenty-three acromegalic patients selected for treatment with external megavoltage pituitary irradiation between 1961 and 1975 developed progressive visual failure. They had received megavoltage external irradiation through multiple portals from a cobalt-60 unit over a period of 3 weeks. Visual deterioration began 2 months to 6 years after irradiation. In two patients the optic nerves were explored. In both, post-mortem later confirmed radiation damage to the optic nerves and hypothalamus. In one case there was also necrosis of the right frontal lobe with necrosis and inflammation of the bone surrounding the pituitary fossa. In the two other patients, extensive clinical and neuroradiological investigation excluded the presence of a suprasellar mass as a cause for this visual failure and a clinical diagnosis of radiation necrosis was made.

Acromegaly↗
PubMed1979

[Functional morphology of the adrenergic innervation and adrenocontaining structures of the lymphoid organs].

Topography of adrenergic neural fibres and adrenodependent structures in lymphoid organs of some mammals (rat, cat, dog, guinea-pig, golden hamster) has been studied by means of Falck's method with other histochemical methods applied simultaneously. In thymus, spleen, tonsils, lymph nodes and appendix adrenergic innervation is performed at the expense of adventitial vascular plexus and some neural fibres directed towards the organs' parenchyma. In the parenchyma of the lymphoid organs some fluorescent interfollicular macrophages and intrafollicular cells with serotonin and catecholamines in their cytoplasm were detected spectroscopically. These two types of cells respond differently to increasing amount of free amines in the organism. Orthochromic mast cells and elastic fibres also possess fluoresent properties which are connected with the presence of serotonin and catecholamines in the lymphoid organs.

Adrenergic Fibers↗
PubMed1978

Surface membrane characteristics and cytochemistry of the abnormal cells in adult acute leukemia.

Membrane marker and cytochemical analyses were carried out on the abnormal cells from 70 adult acute leukemia patients. Such information may (1) supplement standard morphology and serve as a basis for a new classification scheme for acute leukemia, and (2) characterize the surface membranes of granulocyte, lymphocyte, and monocyte "progenitors." Classification of acute lymphoid leukemias solely on the basis of morphology was unsatisfactory. The presence or absence of T- or B-cell markers was helful in classifying lymphoid leukemias. Monocyte progenitors were characteristically nonspecific esterase positive and Fc-receptor and membrane-IgG positive, but poorly phagocytic. Promyelocytes and myelocytes were frequently Fc-receptor positive and consequently positive for surface immunoglobulin. Myeloblasts were characteristically Fc-receptor negative. We conclude that surface membrane markers are essential in diagnosing lymphoid leukemias and helpful in nonlymphoid acute leukemias, and that cytochemistry is essential in delineating lymphoid from nonlymphoid leukemias and in subclassifying the latter.

Acute Disease↗
PubMed1978

[Activity and distribution of biogenic amines in thymus and spleen structures following administration of iso- and heterologous erythrocytes].

It was found that injection of heterological erythrocytes caused as soon as in 15 minutes displacement of noradrenaline from the efferent nerve endings and an essential re-building of metabolism of the central follicular cells and monoamine containing cells of the spleen marginal sinus, cortical fluorescent cells and mast cells of the thymus. Inversion of the medullary substance was revealed in the thymus.

Adrenergic Fibers↗
PubMed1978

Antiserums for immunofluorescent enumeration of human T lymphocytes utilizing fluoresceinated staphylococcal protein A.

Five lots (100 ml or more) of heterologous antiserums specific for human T lymphocytes were prepared using human or Rhesus monkey thymocytes as immunogens. After appropriate adsorptions, these antiserums reacted by immunofluorescence with 68% of human peripheral blood mononuclear cells and 98% of human thymocytes, with E-rosette--positive cells but not with EAC-rosette--positive cells or five human B-lymphoblastoid-cell lines. Blocking experiments showed that Rhesus monkey thymocytes share thymic antigenic determinant(s) with humans. E-rosette receptors modulated independently from T-cell heteroantigens. Non-E--rosetting neoplastic T cells were identified in several patients with lymphoproliferative malignancies. Applying both the E-rosette assay and the anti-T-cell serum provides a better method of defining the biologic properties of normal and neoplastic T lymphocytes. Standardization of immunofluorescent conjugates for human T- or B-cell enumeration is simplified if large lots of well-characterized antiserums are available.

Animals↗