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Biomedical subjects

D S Ellis

Publications and source records attributed to D S Ellis.

At least 91 records · Page 5Linked to original sources
PubMed1978

Ebola virus: a comparison, at ultrastructural level, of the behaviour of the Sudan and Zaire strains in monkeys.

Histopathological and electron microscopical examination of human liver specimens collected during the Ebola haemorrhagic fever outbreaks in Zaire and Sudan indicated that Zairean strains of the virus produced more extensive lesions. Experimental infection of rhesus monkeys wiht Zairean and Sudanese strains of Ebola virus produced similar changes to those found in man. In Zairean strain infections large numbers of virus particles were found in the liver, lung and spleen accompanied by extensive necrosis in the spleen. In Sudan strain infections particles were found only in the liver and in greatly reduced numbers. The main distinction lay in the high proportion of aberrant particles found with the Sudanese strain. The possibility of these being defective particles is discussed.

Animals↗
PubMed1976

Studies with Brugia pahangi. 14. Intrauterine development of the microfilaria and a comparison with other filarial species.

The intrauterine development of Brugia pahangi embryos was followed from after fertilization to birth, using light and electron microscopy. The origin and development of the sheath of the microfilaria and its possible role in the nutrition of the developing embryo were particularly investigated. Comparisons were drawn with the intrauterine development of other filarial species. The egg shell of the B. pahangi embryo is distinct from the oolemma and forms the sheath of the microfilaria. It is suggested that the electron dense material released by cells of the uterine wall and passing along the channels between the egg shells of adjacent embryos is nutritive. The death of large numbers of developing embryos in the central uterine lumen is probably caused by overcrowding as their size rapidly increases, leading to nutritional deficiency.

Animals↗
PubMed1976

Filaments of Trypanosoma brucei: some notes on differences in origin and structure in two strains of Trypanosoma (Trypanozoon) brucei rhodesiense.

Filaments attached to trypanosomes of two strains of T. (T.) brucei were studied by electron microscopy and two distinct types identified: short-thick and long-thin. The former are associated with stumpy trypanosomes and are secretions, via the flagellar pocket, which originate in the area of the Golgi complex, during the infection of the host. They are referred to as 'secretory filaments'. Their diameter is 0.09 to 0.14 mum. The long-thin filaments are associated with slender forms of trypanosome in various artificial situations; those shown by negative staining are believed to be cytoplasmic extrusions from the anatomically weak extremities of the parasite and are referred to as 'plasmanemes'. Their diameter is 0.06 mum. Both types appear to maintain their structure without the aid of the normal type of unit membrane as myelin formations.

Animals↗
PubMed1972

A cytoplasmic polyhedrosis virus in midgut cells of Anopheles stephensi and in the sporogonic stages of Plasmodium berghei yoelii.

Although it has been known for some time that nuclear and cytoplasmic polyhedrosis viruses may infect the larval stages of mosquitos capable of transmitting mammalian malaria this paper reports for the first time the presence of a cytoplasmic polyhedrosis virus in adult Anopheles stephensi. The virus was shown to be present in sporogonic stages of Plasmodium berghei yoelii with which the mosquitos were infected. It is possible that other viruses may affect both vector and malaria parasites. Further studies are required of viral infections in mosquitos as a possible method of biological control.

Animals↗