Legal trends in bioethics.
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Acquired Immunodeficiency Syndrome↗
Biomedical subjects
D S Davis
Publications and source records attributed to D S Davis.
Use of bait containing triclabendazole to treat Fascioloides magna infections in free ranging white-tailed deer.
Triclabendazole-medicated corn bait was given to white-tailed deer (Odocoileus virginianus) on the Welder Wildlife Refuge, Sinton, Texas (USA), at a dose of 11 mg/kg body weight per deer per day for seven days, for control of Fascioloides magna. Medicated bait was offered for one week each during the winters of 1987, 1988, and 1989. Deer collected from treated areas, from baited control and from unbaited control areas were examined before the start of the study in 1987, and four weeks after the end of the baiting period in each of three years. Prior to the study, prevalence of fluke infection was 68%. After treatment with triclabendazole medicated corn, 13 (56%) of 23 deer collected were infected with flukes of which 15% had live parasites; this was evidence for therapeutic treatment. Of the deer collected in the baited and unbaited control areas, 63% and 80%, respectively, were infected only with live flukes. Prevalence of live flukes in deer was significantly (P < 0.05) lower in the treatment pasture than in the baited or unbaited control areas in each of the three years. Efficacy of the baiting system over the three years was 63% when comparing the treatment area and the baited control area.
Animals↗
Does "no" mean "yes"? The continuing problem of Jehovah's Witnesses and refusal of blood products.
The law maintains that the choice of competent adult Witnesses not to receive blood products must be respected. Yet many care providers believe that Witnesses, when actually faced with a life-threatening emergency, want their stated choice to be overriden--which permits them to evade the spiritual consequences of their unstated preference.
Blood Transfusion↗
It ain't necessarily so: clinicians, bioethics, and religious studies.
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Bioethical Issues↗
Letter from abroad: leaves from a research diary.
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Adult↗
An enzyme-linked immunosorbent assay for detecting anthrax antibody in white-tailed deer (Odocoileus virginianus): evaluation of anthrax vaccination and sera from free-ranging deer.
An enzyme-linked immunosorbent assay for anthrax antibody in white-tailed deer (Odocoileus virginianus) was developed and used to evaluate a vaccination study and compare sera from hunter-killed deer in anthrax endemic and non-endemic areas. Deer subcutaneously vaccinated with anthrax avirulent spore vaccine developed specific antibody to protective antigen (PA) which was significantly higher than the non-vaccinated controls at 30, 60, 90, and 240 days post-vaccination. There was no difference between the levels of antibody to PA between deer in anthrax endemic and non-endemic areas.
Animals↗
Shifting the burden of proof.
The law places an extremely heavy burden of proof on those who wish to remove life support--even for patients in persistent vegetative states. A number of public opinion polls show that up to 85 percent of Americans would not want artificial nutrition and hydration for themselves under such circumstances. In light of these findings, a different evidentiary standard is appropriate.
Advance Directives↗
Those who don't give.
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Emigration and Immigration↗
Organ transplants, foreign nationals, and the free rider problem.
There is strong sentiment for a policy which would exclude foreigners from access to organs from American cadaver donors. One common argument is that foreigners are 'free riders'; since they are not members of the community which gives organs, it would be unfair to allow them to receive such a scare resource. This essay examines the philosophical basis for the free rider argument, and compares that with the empirical data about organ donation in the U.S. The free rider argument ought not to be used to exclude foreign nationals because it is based on fallacious assumptions about group membership, and how the 'giving community' is defined. Polls show that even among the seventy-five per cent of Americans who support organ donation, only seventeen per cent had taken the small step of filling out donor cards. Therefore, it goes against logic to define the giving community as coextensive with American residency, while excluding foreigners who might well have become donors had they lived in countries which provided that option.
Emigration and Immigration↗
Comparison of results from five serologic methods used for detecting Brucella abortus antibody activity in coyote sera.
A total of 423 serum samples representing 94 coyotes which were wild trapped in east Texas were used to compare the serologic results from five different methods for detecting antibodies to Brucella abortus. The sera were tested for Brucella spp. antibody activity by the Card (CARD), rivanol precipitation (RIV), standard agglutination tube (SAT), cold complement fixation test (CF), and enzyme linked immunosorbent assay (ELISA) methods. Each serum sample selected for this comparison demonstrated antibody activity by one or more of the five serologic methods. When the serologic results of the five different methods were compared, 143 sera were positive according to the CF test and agreement was 67.1-70.6% with CARD, RIV and SAT. The maximum agreement for CF positive was with CARD (70.6%) and the lowest agreement fro CF negative was also with CARD (56.4%). Agreement among the serologic methods for the SAT positive ranged from 69.1% (CARD) to 72.7% (RIV). Agreement between SAT and ELISA was poor with only 38.1% agreement for SAT positive and 11.3% agreement for SAT negative. Agreement between methods for CARD positive sera was poor, with a low of 43% for both SAT and ELISA, and a high of 55.6% for RIV. Agreement between methods for 149 RIV positive sera was 83.2% for CARD, 67.8% for SAT, 64.4% for CF and only 50.3% for ELISA. Agreement between methods for ELISA positive results ranged from 49.0% for RIV to 62.7% for CARD.(ABSTRACT TRUNCATED AT 250 WORDS)
Animal Diseases↗
Brucella abortus in Bison. II. Evaluation of strain 19 vaccination of pregnant cows.
Protection against Brucella abortus induced abortion and infection provided by strain 19 (S19) vaccination was evaluated in American bison (Bison bison). Forty-eight pregnant bison were manually inoculated (MI) with S19 vaccine, 44 were ballistically inoculated (BI) with an absorbable hollow pellet containing lyophilized S19, and 46 were manually injected with buffered saline as non-vaccinated controls (NVC). All bison were Brucella spp. seronegative prior to the experiment, in the second trimester of pregnancy, and were randomly assigned to experimental groups. Approximately 60 days post-vaccination, abortions were observed in the vaccinated bison. Brucella abortus strain 19 was recovered from a bison that had recently aborted, her fetus, and from 11 of 12 other aborted fetuses. Fifty-eight percent (53 of 92) of vaccinated bison aborted, and no abortions were observed in the NVC bison. One cow aborted during her second post-vaccinal pregnancy and S19 was identified from the dam and fetus indicating that chronic S19 infections can occur in bison. Positive antibody titers were present 10 mo post-vaccination in 73% (66 of 91) of the bison. Thirteen mo post-vaccination, 30 MI vaccinates, 27 BI vaccinates, and 30 NVC bison were challenged during the second trimester of pregnancy with 1 x 10(7) CFU of B. abortus strain 2308 via bilateral conjunctival inoculation. Protection against abortion was 67% (P less than or equal to 0.0001) for vaccinated bison compared to 4% in NVC. Protection against B. abortus infection was determined to be 39% (P greater than or equal to 0.001) for vaccinates and 0% (zero of 30) for NCV. Persistent antibody titers, vaccine induced abortions, and chronic S19 infections indicate that the S19 vaccine doses used in this study are not suitable for pregnant bison.
Abortion, Veterinary↗
Slim just left town: decisionmaking on an intensive care unit.
The title of this paper comes from an incident that occurred while I was participating in morning rounds on the pediatric and surgical intensive care unit of a large, midwest tertiary care center. The patient under discussion was an eight-week-old girl who had been born without kidneys, and who had been cared for on the unit for seven weeks. In the previous week, the baby's condition had gone steadily downhill, as she experienced on medical catastrophe after another. One of the nurses asked the staff doctor who was leading rounds that morning, "What are the baby's chances?" The physician replied, "Her chances are slim." To which one of the young residents immediately answered, "Slim just left town."
Adult↗
"Dealing with real Jewish patients".
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Abortion, Legal↗
Effect of psychiatric liaison nurse specialist consultation on the care of medical-surgical patients with sitters.
One hundred seven patients in an acute care setting who had lay sitters to provide the constant observation judged necessary to meet their safety needs were studied to determine the effect of psychiatric liaison nurse specialist (PLNS) consultation on nursing care and the use of sitters. After placement in either a suicidal or nonsuicidal group, subjects were randomly assigned to receive consultation or not. Outcome variables of number of sitter shifts, number of nursing note observations, number of patient and sitter incidents and length of hospital stay were considered. Multiple analysis of variance indicated no significant differences among the groups for number of sitter shifts or number of nursing note observations. A significant main effect for group on length of hospital stay was found with suicidal patients having a significantly shorter hospital stay. Number of patients and sitter incidents were too small for analysis.
Adult↗
Localization of adenovirus-encoded DNA replication proteins in the nucleus by immunogold electron microscopy.
The distribution of three adenovirus-encoded DNA replication proteins in the nucleus of human 293 cells was studied by immunogold electron microscopy. The infected nuclei contained four morphologically distinct inclusions. They were highly electron-dense granules (type I), compact fibrogranular masses of medium electron density (type II), filamentous masses of low electron density (type III) and large polygonal crystals (type IV). In immunogold labelling studies, antibodies to the adenovirus single-stranded DNA-binding protein (DBP) and antibodies to single-stranded DNA showed extensive binding to the type III inclusions. The antibodies to the adenovirus DNA polymerase (AdPol) and terminal protein (TP) predominantly labelled type II inclusions. Double immunogold labelling studies detected low levels of AdPol and TP in type III inclusions and DBP in type II inclusions. The selective distribution of DNA replication proteins suggests that the type II and III inclusions represent two functionally different entities that may be involved in two different aspects of adenovirus DNA replication, i.e. chain initiation and elongation.
Adenoviridae↗
Use of albendazole in feed to control Fascioloides magna infections in captive white-tailed deer (Odocoileus virginianus).
Thirty-six adult white-tailed deer (Odocoileus virginianus) naturally infected with Fascioloides magna were captured and randomly assigned to four groups. Each group was fed pelleted feed coated with albendazole for each of seven consecutive days to deliver the drug at a dose rate of approximately 0.0, 5.0, 8.5, or 16.5 mg/kg bodyweight/day. At 7 wk posttreatment, each animal was euthanized and necropsied. Effects of albendazole treatment included significant reduction (P less than 0.05) in parasite egg count per gram of feces and increase in serum albumin concentration (P less than 0.05). Smaller parasites or remains of dead parasites were seen at the end of migratory tracks in the treated groups. Efficacy of the drug was 82 to 84%.
Administration, Oral↗
Brucella abortus in captive bison. I. Serology, bacteriology, pathogenesis, and transmission to cattle.
Two groups of six, non-brucellosis vaccinated, brucellosis seronegative pregnant American bison (Bison bison) were individually challenged with 1 x 10(7) colony forming units (CFU) of Brucella abortus strain 2308. Three days after challenge, each bison group was placed in a common paddock with six non-vaccinated, brucellosis susceptible, pregnant domestic heifers. In a parallel study, two groups of six susceptible, pregnant cattle were simultaneously challenged with the identical dose as the bison and each group was placed with six susceptible cattle in order to compare bison to cattle transmission to that observed in cattle to cattle transmission. Blood samples were collected from bison and cattle weekly for at least 1 mo prior to exposure to B. abortus and for 180 days post-exposure (PE). Sera from the bison and cattle were evaluated by the Card, rivanol precipitation, standard plate agglutination, standard tube agglutination, cold complement fixation tube, warm complement fixation tube, buffered acidified plate antigen, rapid screening, bovine conjugated enzyme linked immunosorbent assay, bison or bovine conjugated enzyme linked immunosorbent assay, and the hemolysis-in-gel techniques for the presence of antibodies to Brucella spp. At the termination of pregnancy by abortion or birth of a live-calf, quarter milk samples, vaginal swabs, and placenta were collected from the dam. Rectal swabs were collected from live calves, and mediastinal lymph nodes, abomasal contents and lung were taken at necropsy from aborted fetuses for culture of Brucella spp. These tissues and swabs were cultured on restrictive media for the isolation and identification of Brucella spp. Pathogenesis of brucellosis in bison was studied in an additional group of six pregnant bison which were challenged with 1 x 10(7) CFU of B. abortus strain 2308. One animal was euthanatized each week PE. Tissues were collected at necropsy and later examined bacteriologically and histologically. Lesions of brucellosis in bison did not significantly differ grossly or histologically from those in cattle. There were six abortions and two nonviable calves in the bison group, as compared to nine abortions in the 12 similarly inoculated cattle. As determined by bacterial isolations, transmission of B. abortus from bison to cattle (five of 12 susceptible cattle became infected) did not differ statistically from cattle to cattle transmission (six of 12 susceptible cattle became infected) under identical conditions. No single serologic test was constantly reliable to diagnosing B. abortus infected bison for 8 wk PE.(ABSTRACT TRUNCATED AT 400 WORDS)
Agglutination Tests↗
Old and thin.
Viewing an elderly patient's refusal of food from the perspective of the jain tradition of sallekhana (voluntary starvation) permits the author to reconcile her need to "do something" with her belief in the principle of patient autonomy.
Aged↗