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Biomedical subjects

D S Cooper

Publications and source records attributed to D S Cooper.

95 records · Page 6Linked to original sources
PubMedDate not supplied

Cardiac function in mild and severe primary hypothyroidism.

One hundred patients with mild to severe primary hypothyroidism have been analyzed for abnormalities in left ventricular performance utilizing noninvasive techniques. These studies have revealed significant abnormalities in cardiac function which correlated inversely with serum T4 levels. The abnormalities in cardiac function were completely reversible with thyroid hormone therapy. Even in patients with mild subclinical hypothyroidism, significant changes in left ventricular performance were achieved by doses of thyroid hormone which normalized TSH secretion. Therapy with either L-T4 or L-T3 resulted in normal cardiac function though L-T3 produced normal cardiac function on lower doses than were necessary to normalize TSH secretion. These studies are intended to provide new information on the optimal treatment of hypothyroidism.

Adolescent↗
PubMedDate not supplied

Central nervous system side effects associated with zolpidem treatment.

Zolpidem is one of the newer medications developed for the treatment of insomnia. It is an imidazopyridine agent that is an alternative to the typical sedative-hypnotic agents. Zolpidem use is gaining favor because of its efficacy and its side effect profile, which is milder and less problematic than that of the benzodiazepines and barbiturates used to treat insomnia. Still, side effects are not uncommon with zolpidem use. We report a series of cases in which the patients developed delirium, nightmares and hallucinations during treatment with zolpidem. We will review its pharmacology, discuss previous reports of central nervous system side effects, examine the impact of drug interactions with concurrent use of antidepressants, examine gender differences in susceptibility to side effects, and explore the significance of protein binding in producing side effects.

Adult↗
PubMedDate not supplied

Phonatory effects of thyroid cartilage fractures.

Blunt trauma can cause a wide range of injuries to the cartilaginous framework of the larynx. The severity of injury that is required to cause a permanent disorder of vocal function if left untreated has not been defined. A study using excised canine and human larynges was undertaken to identify the effects of minimal displacement or malalignment in simulated thyroid cartilage fractures on selected voice production measurements. These fractures were found to cause changes in glottal configuration sufficient to affect glottal resistance as well as amplitude and noise content of the voice signal produced by each larynx. Therefore, relatively minor injuries of the thyroid cartilage may cause potentially serious disorders of phonation.

Animals↗
PubMedDate not supplied

Pediatric sertraline overdose.

Sertraline (Zoloft) is a selective serotonin reuptake inhibitor that is commonly used in adults in the treatment of mood and anxiety disorders. Whereas it also is used to treat these illnesses in children, it is not currently approved by the Food and Drug Administration for use in this population. Sertraline use has been increasing secondary to its efficacy and its more tolerable side effect profile than the tricyclic antidepressants. It is also much safer in overdose than the tricyclic antidepressants. Although there have been numerous reports of sertraline overdose in adults, reports in the pediatric population are much less common. We review the literature regarding sertraline overdose in children, describe a case of sertraline ingestion in a 22-month-old infant, and discuss the treatment of such an overdose.

1-Naphthylamine↗