Search PubMed⌕ Search

Biomedical subjects

D S Bruce

Publications and source records attributed to D S Bruce.

5 recordsLinked to original sources
PubMed1992

Suppression of guinea pig ileum induced contractility by plasma albumin of hibernators.

Previous studies suggest that hibernation may be regulated by internal opioids and that the putative "hibernation induction trigger" (HIT) may itself be an opioid. This study examined the effect of plasma albumin (known to bind HIT) on induced contractility of the guinea pig ileum muscle strip. Morphine (400 nM) depressed contractility and 100 nM naloxone restored it. Ten milligrams of lyophilized plasma albumin fractions from hibernating ground squirrels, woodchucks, black bears, and polar bears produced similar inhibition, with partial reversal by naloxone. Five hundredths mg of D-Ala2-D-Leu5-enkephalin (DADLE) also inhibited contractility and naloxone reversed it. Conclusions are that hibernating individuals of these species contain an HIT substance that is opioid in nature and summer animals do not; an endogenous opioid similar to leu-enkephalin may be the HIT compound or give rise to it.

Animals↗
PubMed1992

Activation of T cells in vivo using anti-CD3 and staphylococcal enterotoxins.

One of the major problems in clinical immunity is that neoplastic and virally infected cells are insufficiently immunogenic to trigger an immune response. During the past several years, our laboratory has explored the use of T-cell-specific reagents including monoclonal antibodies (MAbs) and staphylococcal enterotoxins to amplify immune responses. This report summarizes our efforts to augment immunity with these agents.

Animals↗
PubMed1978

Effects of varying thermal and apneic conditions on the human diving reflex.

An investigation of the importance of water contact, cooling, and apnea to the development of the diving reflex in humans was performed in two experimental series. The first series involved exposure of different parts of the face to direct water contact, while the second consisted of face immersion in water baths of varying temperatures. Data were obtained on heart rate (ECG's) and peripheral vasoconstriction (by indirect blood pressure using sphygmomanometry). Results were interpreted to indicate that the diving reflex is actuated by both facial cooling and apnea, but not by any direct effect of water contact other than cooling.

Adolescent↗