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D Rush

Publications and source records attributed to D Rush.

At least 37 records · Page 2Linked to original sources
PubMed1988

Defining cellular senescence in IMR-90 cells: a flow cytometric analysis.

Using multiparameter flow cytometric analysis, we find that senescent cells accumulate in a unique cell-cycle compartment characterized in cell-cycle arrest in G1 and a significantly reduced nucleocytoplasmic ratio (genome size/cell mass) relative to cycling cells. With respect to gross cellular phenotype, the quiescent state of senescent cells differs from quiescence induced by density inhibition; the former is associated with a reduction in the nucleocytoplasmic ratio, while the latter is associated with an increase in the nucleocytoplasmic ratio. Senescent cells were present at all passages examined. The frequency of senescent cells was low in early-passage cultures and increased with passage number. Senescence of populations of IMR-90 cells reflects change in the relative frequency of these cells. The frequency of cells with karyotypic changes increased with the progressive accumulation of out-of-cycle cells.

Cell Cycle↗
PubMed1988

The National WIC Evaluation: evaluation of the Special Supplemental Food Program for Women, Infants, and Children. II. Review of past studies of WIC.

We reviewed past work relating WIC benefits to birth weight, perinatal and infant survival, anemia, child growth, and dietary intake. Despite many uncertainties, the probable range of reduction in the rate of low birth weight was approximately 1-2% and the increase in mean birth weight ranged from 0 to approximately 60 g. There was too little information to securely estimate effects of WIC on perinatal and infant mortality nor on the dietary intake of women or children. Although the number of studies was small, there probably were important effects of WIC on rates of childhood anemia. There is too little evidence to come to any conclusion on effects during pregnancy. There is little evidence that the WIC program has affected children's linear growth.

Birth Weight↗
PubMed1988

The National WIC Evaluation: evaluation of the Special Supplemental Food Program for Women, Infants, and Children. III. Historical study of pregnancy outcomes.

We related perinatal outcome and quality of prenatal care between 1972 and 1980 to WIC benefits to pregnant women among 11,154,673 births in 1392 counties in 19 states and the District of Columbia, adjusted for time change and between-county variability. WIC was associated with increased first trimester prenatal care (4.1%, p less than 0.001), decreased inadequate prenatal care (-5.0%, p less than 0.001), longer duration of gestation (0.20 d, p less than 0.05), decreased preterm delivery (-0.92%, p less than 0.05) and increased birth weight (23 g, p less than 0.01). After autocorrelation was accounted for, significance levels for birth weight and frequency of preterm delivery were 0.05 less than p less than 0.10. Including counties with incomplete time series data, the estimated effect on birth weight was 23.9 g (p = 0.004) and on decreased fetal mortality was -2.3/1000 (p = 0.04). Among those with less than 12 y schooling, whites had a 1.8% reduction in preterm birth (p less than 0.05) and blacks a 2.0% reduction (p less than 0.05). The estimated effect on birth weight for less-educated whites was 46.6 g (p less than 0.001). The predominant effects of WIC were on improved physiologic status of the mother and fetus.

Black or African American↗
PubMed1988

The National WIC Evaluation: evaluation of the Special Supplemental Food Program for Women, Infants, and Children. IV. Study methodology and sample characteristics in the longitudinal study of pregnant women, the study of children, and the food expenditures study.

The longitudinal study of pregnant women enrolled a national probability sample of 5,205 women first certified for WIC and 1,358 comparable low-income pregnant women in 174 WIC clinics located in 58 areas in the contiguous 48 states and in 55 prenatal clinics without WIC programs in counties with low program coverage. The women completed 24-h dietary recalls, histories of food expenditures, health care utilization, health and sociodemographic status, and anthropometric assessment. At late-pregnancy follow-up 3,967 WIC and 1043 control women were interviewed and 853 WIC and 762 control women completed 1-wk food expenditure diaries. Birth outcome was abstracted (from hospital records) for 3,863 WIC and 1058 control women. Anthropometry, dietary intake, health, and use of health services were related to WIC among 2,619 random low-income preschoolers. Psychological development was assessed in 526 children aged 4 and 5 y. Control women had higher income, education, and employment status; therefore, WIC program benefits probably were underestimated.

Child Nutritional Physiological Phenomena↗
PubMed1988

The National WIC Evaluation: evaluation of the Special Supplemental Food Program for Women, Infants, and Children. V. Longitudinal study of pregnant women.

The major associations with the Special Supplemental Food Program for Women, Infants, and Children (WIC) in pregnancy were increased intake of protein, iron, calcium, and vitamin C (four of five targeted nutrients) and of energy, magnesium, phosphorus, thiamin, riboflavin, niacin, vitamin B-6, and vitamin B-12; reversal of low weight gain in early pregnancy; smaller fat stores in late pregnancy; reduced frequency of premature rupture of the uterine membranes; larger infant head circumference with no effect on birth weight and length; increased birth weight and head circumference with better program quality; and lower fetal mortality of appreciable but not significant magnitude. Incremental energy intake was comparable to that in most small-scale supplementation trials. There was no evidence of effects on frequency of prenatal care, use of alcohol or tobacco, the intention to breast-feed, or the rate of breast-feeding. Maternal alcohol intake was associated with depressed infant head circumference, over and above effects on birth weight and length.

Anthropometry↗
PubMed1988

The National WIC Evaluation: evaluation of the Special Supplemental Food Program for Women, Infants, and Children. VI. Study of infants and children.

The major associations with the Special Supplemental Food Program for Women, Infants, and Children (WIC) in preschool children were better dietary intake associated with current WIC participation, especially for Fe, vitamin A, and vitamin C, but there were no increases in energy intake and, after infancy, no residual benefits from past WIC participation; strongest dietary effects among children who were poor, black, or in single-parent or large families (children lost to WIC were as needy as those currently enrolled); shorter stature, suggesting effective targeting (with enrollment in utero there was no parallel deficit in head circumference, which is consistent with results for newborns); better immunization and more frequent regular source of health care but no more frequent use of preventive health services; and better vocabulary with WIC participation begun in utero; better digit memory with entry into the program after the first birthday (differences that emerged only after statistical adjustment for sociodemographic factors); and more advantageous child behavior (NS).

Body Height↗
PubMed1988

The National WIC Evaluation: evaluation of the Special Supplemental Food Program for Women, Infants, and Children. VII. Study of food expenditures.

Recalls of monthly family food expenditure, taken before and after maternal WIC benefits, were obtained from 4,219 WIC and 785 control women; 1-wk expenditure diaries (at follow-up) were obtained from 1,031 WIC and 551 control women chosen randomly. Control families had higher incomes, spent more on groceries and in restaurants, and received fewer food stamp benefits. Women probably underreported the value of WIC benefits by recall (WIC vouchers are not dollar denominated). Although control families were more affluent, there were consistent effects of children's WIC benefits on weekly family grocery expenditure by diary ($6.10, p less than 0.05) and by recall ($2.14, p less than 0.01, and $1.48, p less than 0.05). WIC benefits to infants were associated with very large (but not significant) increments in grocery spending by diary ($7.57). WIC benefits to the pregnant woman were strongly associated with larger amounts of WIC food entering the household (as were infant and child benefits) but effects on grocery spending were unclear.

Costs and Cost Analysis↗
PubMed1988

Perinatal outcome, maternal weight gain, cigarette smoking and social status in Jerusalem.

Past studies have reported consistent depression of birthweight among offspring of mothers who smoked during pregnancy, but depression of maternal weight gain and increase in perinatal mortality have been inconsistent; these have been generally associated with smoking among women of low social status. Among 8,263 pregnancies in West Jerusalem from 1974 to 1976 to women who were not religiously observant, birthweight was low among infants of smokers, but maternal weight gain was not depressed nor was perinatal mortality increased. Thus, the experience of these women in Jerusalem was similar to that of continental European, and affluent British and North American women. There appears to be no inevitable link between maternal smoking and depressed weight gain, nor with markedly increased perinatal mortality (however, since numbers of deaths were small, this observation requires replication). These results are consistent with the possibility that sustained weight gain among smokers may have contributed to the suppression of an effect of maternal smoking on increased perinatal mortality.

Birth Weight↗
PubMed1988

The National WIC Evaluation: evaluation of the Special Supplemental Food Program for Women, Infants, and Children. I. Background and introduction.

The Special Supplemental Food Program for Women, Infants, and Children (WIC) aims to improve the nutrition and health of low-income, nutritionally at-risk pregnant women and preschool children with supplemental food, nutrition education, and coordination of health care. Started in 1972, it recently served greater than 3.4 million persons monthly and at a cost of $1.66 billion annually. The National WIC Evaluation (NWE) consisted of four studies: The historical study estimated changes in birth outcome attributable to WIC from 1972 to 1980 in 19 states and the District of Columbia from WIC program data and vital statistics. The longitudinal study of pregnant women compared dietary intake, weight gain, anthropometry, duration of gestation, birth weight, and infant length and head circumference between a representative national sample of WIC participants and economically comparable women. The cross-sectional study of preschool children related WIC to dietary intake, anthropometry, and psychological development. The food expenditures study estimated the impact of WIC on family grocery and other food expenditures.

Child Welfare↗
PubMed1987

Iatrogenic caloric restriction in pregnancy and birthweight.

The effects on fetal growth of iatrogenic prescription for dietary restriction in pregnancy have been infrequently assessed, and results have suggested large decrements in birthweight. We therefore related maternal dietary restriction to fetal growth among participants in the National Collaborative Perinatal Project at the Columbia Presbyterian Medical Center in New York. There were 255 women who delivered term infants with birthweights under the 31st percentile (low birthweight), who were each matched to women who delivered heavier term infants, within ethnic and gestational age strata. On review of antenatal records, 198 women were identified who had received a physician's recommendation to restrict caloric intake to 1800 kcal/day or below. The odds ratio between caloric restriction and low birthweight was 0.88 (not significant [NS]). Rates of maternal weight gain were controlled by linear multiple regression analysis, since higher weight gain was associated both with the likelihood of having a diet prescribed and with higher birthweight. With control for weight gain, although the odds ratio was reversed, the change was of small magnitude and not statistically significant. We found no relationship between medical advice to limit caloric intake during pregnancy and intrauterine growth retardation. Since women asked to limit caloric intake continued to gain more weight than others, the results are consistent with lack of compliance with the dietary regimen.

Adult↗
PubMed1986

The effects of maternal cigarette smoking on placental morphology, histomorphometry, and biochemistry.

We related cigarette smoking during pregnancy to the macroscopic and microscopic morphology, histomorphometry, and biochemistry of the placenta among participants in The Prenatal Project, a randomized, controlled trial of nutritional supplementation during pregnancy. The aim was to ascertain if the harmful effects of cigarette smoking on the fetus were reflected, and possibly mediated, by changes in the placenta, and whether such changes might be modified by the nutritional supplements, parallel to the nutritional reversal of birthweight depression among heavy smokers. Maternal smoking was associated with increased alkaline ribonuclease (RNase) levels, possibly resulting in disturbed protein synthesis. More smokers had placentas with villous hyperplasia on histologic examination. This was accompanied by biochemical evidence of significantly increased cellularity (increased DNA/gm of placental mass and decreased protein/DNA ratios) and (nonsignificant) trends to reduced syncytial villous cell size on histomorphometry. There were joint effects of cigarette smoking and use of either form of nutritional supplementation on the fibrin and stoma components of the villi, but such changes are not necessarily pathologic. The significant reduction in pathology of the stem villi among smokers was confined to those who were nutritionally supplemented, particularly heavy smokers. This change may thus have reflected the protective effects of supplementation on the birthweight of the offspring of these heavy smokers.

Cell Division↗
PubMed1985

Prenatal care and the prevention of preterm delivery.

This paper reports the methods and results of an innovative program of prenatal care, designed to prevent preterm delivery in Clamart, France, during 1976-1981. Rates of preterm delivery among women who entered the prenatal care program early in pregnancy (and, thus, could derive full benefit of the program) were compared with those among two comparison groups: (1) women who entered the same program later in pregnancy; and (2) women who delivered in Paris. In the first comparison, women who entered the program early had significantly lower rates of preterm delivery than did women who entered later, even when stratified by various risk factors, and when high-risk women were eliminated altogether. In the second comparison, the early care group in Clamart did not exhibit the usual inverse relationship between socioeconomic status and rates of preterm delivery. The usual significant inverse relationship was found in the Clamart population as a whole, and in the Paris series.

Adolescent↗
PubMed1984

The effects of dietary supplementation during pregnancy on placental morphology, pathology, and histomorphometry.

We related the macroscopic and microscopic morphology and the histomorphometry of the placenta to prenatal nutritional supplementation. In the Prenatal Project, a controlled clinical trial, three dietary treatments (supplement, a high-protein beverage; complement, a balanced protein-calorie beverage, or routine vitamin and mineral tablets) were randomly allocated to poor Black pregnant women, and the outcome was assessed. Herein we report the effects on placental morphology and histomorphometry. There were significantly fewer preterm deliveries in the complement group, and this was reflected by an increase in the size of decidual cells, an index associated with placental aging. Several other characteristics of the placentas of the complement group may have been more directly associated with improved perinatal outcome: decreased intervillous fibrin, lower incidence of gross surface infarct, and smaller (and presumably less edematous) cells of the villous stroma, may have mediated increased placental perfusion. There was no evidence of any placental change associated with the increase in very preterm delivery and the highly significant depressed birth weight among preterm deliveries in the supplement group. The significantly lower incidence of meconium staining of Wharton's jelly among controls seems likely to have been a chance finding. While there were several other indices that reflected placental aging, the significantly increased chorioamnionitis, acute funisitis , and acute decidual inflammation among placentas of those who delivered prematurely [the former two associated with very early delivery (less than 35 wk gestation)] were likely to have been involved as causes of premature delivery.

Clinical Trials as Topic↗