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Biomedical subjects

D Rubin

Publications and source records attributed to D Rubin.

At least 91 records · Page 5Linked to original sources
PubMed1978

Traumatic diaphragmatic hernia.

A series of 58 cases of traumatic diaphragmatic hernia following blunt and penetrating injury is reviewed. The problems of radiodiagnosis are outlined and the need for barium contrast studies of the entire gastrointestinal tract to ensure recognition of isolated small bowel herniation is emphasized. Surgical access via laparotomy is recommended in the immediate post-traumatic presentation, whereas thoracotomy is preferable in cases diagnosed after a latent interval. Penetrating injury resulted in smaller diaphragmatic defects, greater morbidity and higher mortality due mainly to infective complications.

Adolescent↗
PubMed1977

Osteogenesis imperfecta congenita: evidence for a generalized molecular disorder of collagen.

Collagen from bone (femur and calvarium), rib cartilage, skin, tendon, sclera, and cornea has been isolated and purified from a deceased 4-day-old infant with osteogenesis imperfecta congenita. Amino acid analysis indicated that the content of hydroxylysine was doubled in bone collagen and increased by 55% in that of cartilage as compared with age-matched normal tissues. The levels of covalently bound glucose and galactose were proportionately increased in both collagens. Collagen purified from other tissues revealed smaller increases in lysyl hydroxylation. These data suggest that at least one form of osteogenesis imperfecta congenita is associated with a molecular alteration of collagen involving hydroxy-lysine and that this alteration is particualrly marked in collagens obtained from calcifying tissues.

Amino Acids↗
PubMed1975

Inhibition by 2,4-dinitrophenol of 9,10-dimethyl-1,2-benzanthracene carcinogenesis in the hamster cheek pouch.

After topical treatment of cheek pouches of 10 hamsters with 9,10-dimethyl-1,2-benzanthracene and 2,4-dinitrophenol for 10 weeks no carcinomas developed in any of the animals. After treatment of 10 animals with the carcinogen only, there were 49 carcinomas in the 8 survivors. Inhibition of chemical carcinogenesis by dinitrophenol was tentatively attributed to suppression of ATP synthesis and to activation of ATPase by dinitrophenol.

9,10-Dimethyl-1,2-benzanthracene↗
PubMed1975

Chemical carcinogenesis in the hamster cheek pouch. Influence of inhibitors and inducers of alkaline phosphatase.

Squamous cell carcinomas were induced in the hamster cheek pouch with 9,10-dimethyl-1,2-benzanthracene. The process of carcinogenesis was inhibited by phenylphosphate, an inducer of alkaline phosphatase. Orthophosphate and l-phenylalanine, which inhibit alkaline phosphatase, had a promoting effect on tumor formation. The results are in accordance with those of previous studies on the effect of inducers of alkaline phosphatase on chemical carcinogenesis. The effect of the studied substances on carcinogenesis was apparently unrelated to the presence of phenyl or phosphate groups or of steroid rings. The tumor inhibition or promotion seemed to be related to the potential of the tested substances to induce or inhibit alkaline phosphatase activity.

9,10-Dimethyl-1,2-benzanthracene↗
PubMed1970

The no--or the yes and the how--of sex for patients with neck, back and radicular pain syndromes.

The restrictions imposed upon sexual activity by neck, back and radicular pain syndromes are of serious concern to the patient. In recent years the subject of When, and even How is raised with increasing frequency, and the patient expects the physician to reply with appropriate answers. The reply must be tempered by the level of the patient's recovery, the evaluation of what other activities the patient can perform without pain or with minimal pain and the method to be used. Sexual activity may precipitate recurrent pain or aggravate existing pain in the same manner as lifting, pushing, pulling or any other physical activity, if performed too early or too vigorously in the course of recovery from neck, back or radicular pain syndromes. In dealing with the problem of recovery from painful musculoskeletal or neuromuscular states, timing is of the utmost importance. Unless a timetable is specifically outlined, recurrences are common, and the condition may become chronic. The inability of the patient to deal satisfactorily with the sexual aspect of his daily living may, in itself, lead to emotional tensions and guilt feelings which may delay or prevent recovery. There is need to handle this problem at every level of the involvement in order to achieve a desirable end result-namely, the absence of pain and its replacement with pleasure.

Back Pain↗