Decrease in hepatic cytochrome P-450 and catalase following allylisopropyl acetamide: the effect of concomitant hemin administration.
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5-Aminolevulinate Synthetase↗
Biomedical subjects
D Rothwell
Publications and source records attributed to D Rothwell.
Meeting the problems of first-generation insulin infusion pumps: clinical trial of a new miniature infuser.
We designed and constructed a new miniature, open-loop insulin infusion pump specifically to overcome the problems of many first generation insulin infusers. Special features are small size, adjustable volumetric basal infusion rate, rapid electronically mediated prandial insulin boosts, facility for doubling and halving the basal infusion rate and/or prandial delivery, and alarms for low battery state, motor over-run, stoppage, and control circuit malfunction. The infuser takes a specially designed syringe prefilled with short-acting insulin, sufficient in most diabetic patients for at least 7 days treatment with 100 U/ml insulin. To test clinical efficacy nine insulin-dependent diabetic patients received continuous subcutaneous insulin infusion (CSII) with the new infuser for periods up to 6 mo. Four patients previously CSII-treated with a first-generation pump and five who were new to CSII achieved and maintained the expected degree of near-normoglycemia. There were no pump breakdowns and a questionnaire completed by patients during the study confirmed ease and simplicity of operation and an appreciation of the advantages of the new pump compared with one widely used first-generation infuser.
Adult↗
Using the TNM system to predict survival in squamous cell carcinoma of the head and neck.
PURPOSE: To create a classification system for prognosis based on the TNM system for patients with squamous cell carcinoma of the Head and Neck such that patient groupings are homogeneous within and heterogenous between. METHOD: 655 consecutive patients with invasive squamous cell carcinoma of the Head and Neck followed prospectively are split into a training set and a test set. Using the training set, the Cox Proportional Hazards Model and the outcome of dead with disease, we create homogenous prognostic levels based on relative risk. Using the test set, we compare our model to others in the literature. RESULTS: Using the training set we identify 5 prognostic levels and using the test set we demonstrate that our model is superior to others for both within group homogeneity and between group heterogeneity. CONCLUSIONS: A simple classification system can be used to group patients for survival and is valid for future study in prognostication.
Carcinoma, Squamous Cell↗